Zobrazeno 1 - 10
of 621
pro vyhledávání: '"Hiroki NAGAI"'
Autor:
Hiroki Nagai, Yuya Adachi, Tenki Nakasugi, Ema Takigawa, Junichiro Ui, Takashi Makino, Masayuki Miura, Yu-ichiro Nakajima
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background The remarkable regenerative abilities observed in planarians and cnidarians are closely linked to the active proliferation of adult stem cells and the precise differentiation of their progeny, both of which typically deteriorate d
Externí odkaz:
https://doaj.org/article/e14762dea9984c6b9cb9ff9e983412e9
Autor:
Tomoki Inoue, Koyo Kubota, Tsubasa Ikami, Yasuhiro Egami, Hiroki Nagai, Takahiro Kashikawa, Koichi Kimura, Yu Matsuda
Publikováno v:
Communications Engineering, Vol 3, Iss 1, Pp 1-9 (2024)
Abstract Time-series clustering is a powerful data mining technique for time-series data in the absence of prior knowledge of the clusters. Here we propose a time-series clustering method that leverages an annealing machine, which accurately solves c
Externí odkaz:
https://doaj.org/article/36e48645dc9d4954be7936a44e88d600
Publikováno v:
eLife, Vol 12 (2024)
Rab GTPases are representative targets of manipulation by intracellular bacterial pathogens for hijacking membrane trafficking. Legionella pneumophila recruits many Rab GTPases to its vacuole and exploits their activities. Here, we found that infecti
Externí odkaz:
https://doaj.org/article/dc58dac948a14e369dbf50d4b75fb61b
Autor:
Ruslan Deviatiiarov, Hiroki Nagai, Galym Ismagulov, Anastasia Stupina, Kazuhiro Wada, Shinji Ide, Noriyuki Toji, Heng Zhang, Woranop Sukparangsi, Sittipon Intarapat, Oleg Gusev, Guojun Sheng
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensati
Externí odkaz:
https://doaj.org/article/142a8b265a0a4cc482b4a5c1deafe764
Autor:
Toshihiko Matsumoto, Tatsuki Ikoma, Shogo Yamamura, Kou Miura, Takao Tsuduki, Takanori Watanabe, Hiroki Nagai, Masahiro Takatani, Hisateru Yasui
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Regorafenib is a standard salvage line therapy used for advanced colorectal cancer (CRC). Recently, trifluridine/tipiracil (TFTD) plus bevacizumab also showed promising efficacy as a salvage line therapy for advanced CRC. However, the effica
Externí odkaz:
https://doaj.org/article/a9e301dfe6fd46189cdfb7cbe6561053
Publikováno v:
Fly, Vol 16, Iss 1, Pp 190-206 (2022)
Adult tissues in Metazoa dynamically remodel their structures in response to environmental challenges including sudden injury, pathogen infection, and nutritional fluctuation, while maintaining quiescence under homoeostatic conditions. This character
Externí odkaz:
https://doaj.org/article/3ebf8a6eee4f452293bbdb09ff7fd99a
Autor:
Toshihiko Matsumoto, Tatsuki Ikoma, Shogo Yamamura, Kou Miura, Takao Tsuduki, Takanori Watanabe, Hiroki Nagai, Masahiro Takatani, Hisateru Yasui
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/7c46308326ce40549021fb815b9358e6
Publikováno v:
Mechanical Engineering Journal, Vol 10, Iss 2, Pp 22-00415-22-00415 (2023)
The effects of cross-sectional shapes of flat-plate pulsating heat pipes (PHPs) on heat-transfer performance were experimentally investigated. The flat-plate PHP, made of aluminum alloy, has a closed-end serpentine channel with 22 turns. Four PHP sam
Externí odkaz:
https://doaj.org/article/78436d88ba2d4598a1278dffc10dfaf3
Autor:
Toshihiko Matsumoto, Shogo Yamamura, Tatsuki Ikoma, Yusuke Kurioka, Keitaro Doi, Tomoyo Yasuda, Shogen Boku, Takashi Kawai, Nobuhiro Shibata, Hiroki Nagai, Takao Tsuduki, Takanobu Shimada, Yusuke Matsumoto, Takehiko Tsumura, Masahiro Takatani, Hisateru Yasui, Hironaga Satake
Publikováno v:
Clinical Medicine Insights: Oncology, Vol 16 (2022)
Background: A trial with trifluridine/tipiracil (FTD/TPI) versus placebo in patients with heavily pretreated metastatic gastric cancer showed that FTD/TPI is effective with manageable toxicity in these patients. However, real-world data on the effect
Externí odkaz:
https://doaj.org/article/6d5c257c05f04838a9c61c5e4a6e0026
Autor:
Tatsuki Ikoma, Mototsugu Shimokawa, Masahito Kotaka, Toshihiko Matsumoto, Hiroki Nagai, Shogen Boku, Nobuhiro Shibata, Hisateru Yasui, Hironaga Satake
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background RAS/BRAF V600E mutations are the most remarkable oncogenic driver mutations in colorectal cancer (CRC) and play an important role in treatment selection. No data are available regarding the clinical and prognostic features of pati
Externí odkaz:
https://doaj.org/article/daed111adc22406db03938d47afb31d4