Výsledky vyhledávání - "Hiroki Hosono"

Akademický článek

Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations

Autor: Koichi Kato, Tomoki Nakayoshi, Rika Nokura, Hiroki Hosono, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 18, p 10119 (2021)

Cytochrome P450 (CYP) 2A6 is a monooxygenase involved in the metabolism of various endogenous and exogenous chemicals, such as nicotine and therapeutic drugs. The genetic polymorphisms in CYP2A6 are a cause of individual variation in smoking behavior

Externí odkaz: https://doaj.org/article/9b1a8f8fc9f14fc7b41b5dc194e7ec4f

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Akademický článek

Integrated Electrochemical Analysis System with Microfluidic and Sensing Functions

Autor: Hiroaki Suzuki, Sanjay Upadhyay, Katsuya Morimoto, Hiroomi Yokomaku, Hiroki Hosono, Wataru Satoh

Publikováno v: Sensors, Vol 8, Iss 2, Pp 1111-1127 (2008)

An integrated device that carries out the timely transport of solutions andconducts electroanalysis was constructed. The transport of solutions was based oncapillary action in overall hydrophilic flow channels and control by valves that operateon the

Externí odkaz: https://doaj.org/article/d3d46957642046b49cb277aecbaaac08

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Akademický článek

Genetic polymorphisms of dihydropyrimidinase in a Japanese patient with capecitabine-induced toxicity.

Autor: Masahiro Hiratsuka, Hiroshi Yamashita, Fumika Akai, Hiroki Hosono, Eiji Hishinuma, Noriyasu Hirasawa, Takahiro Mori

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124818 (2015)

Dihydropyrimidinase (DHP) is the second enzyme in the catabolic pathway of uracil, thymine, and chemotherapeutic fluoropyrimidine agents such as 5-fluorouracil (5-FU). Thus, DHP deficiency might be associated with 5-FU toxicity during fluoropyrimidin

Externí odkaz: https://doaj.org/article/9ea00ae9df1f4206a58f0663093b7ae4

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Stratification of Sulfur Species and Microbial Community in Launched Marine Sediment by an Improved Sulfur-Fractionation Method and 16S rRNA Gene Sequencing

Autor: Yoko Katayama, Tomoyuki Hori, Tomo Aoyagi, Hideyuki Ihara, Mitsuru Takasaki, Hiroki Hosono

Publikováno v: Microbes and Environments

With a focus on marine sediment launched by the tsunami accompanying the Great East Japan Earthquake, we examined the vertical (i.e., depths of 0-2, 2-10, and 10-20 mm) profiles of reduced inorganic sulfur species and microbial community using a newl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9bfd7bda852d082fe2d7d640cc515d
http://europepmc.org/articles/PMC6594742

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Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations

Autor: Akifumi Oda, Tomoki Nakayoshi, Masahiro Hiratsuka, Rika Nokura, Koichi Kato, Yoshinobu Ishikawa, Hiroki Hosono, Eiji Kurimoto

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10119, p 10119 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ea267fe29940a85c2dbe3a8fc78a19
https://doi.org/10.3390/ijms221810119

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Genetic Polymorphisms of CYP2A6 in a Case-Control Study on Bladder Cancer in Japanese Smokers

Autor: Masahiro Hiratsuka, Yoichi Arai, Masaki Kumondai, Noriyasu Hirasawa, Tatsuya Takayama, Takayuki Sugiyama, Takamitsu Sasaki, Haruhiko Sugimura, Kazuhiko Orikasa, Tomio Arai, Seiichiro Ozono, Hiroki Hosono

Publikováno v: Biological & Pharmaceutical Bulletin. 39:84-89

Several of the procarcinogens inhaled in tobacco smoke, the primary risk factor for bladder cancer, are activated by CYP2A6. The association between the whole-gene deletion of CYP2A6 (CYP2A6*4) and a reduced risk of bladder cancer was suggested in Ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5c2bf863fc5f8cf902c3fe76c98502a
https://doi.org/10.1248/bpb.b15-00604

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Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation

Autor: Masamitsu Takahashi, Hiroki Hosono, Yuki Katono, Daisuke Saigusa, Miyabi Ito, Takahiro Saito, Masahiro Hiratsuka, Naoto Suzuki, Masashi Honda, Chiharu Tsukada, Yoshihisa Tomioka, Noriyasu Hirasawa

Publikováno v: Drug Metabolism and Pharmacokinetics. 30:119-122

Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370286e4f1e4653f4a0b000e470e5a00
https://doi.org/10.1016/j.dmpk.2014.09.001

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Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation

Autor: Masahiro Hiratsuka, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, Masamitsu Maekawa, Hiroaki Yamaguchi, Masaki Kumondai, Hiroki Hosono

Publikováno v: Drug metabolism and pharmacokinetics. 33(1)

Cytochrome P450 2A13 (CYP2A13) is responsible for the metabolism of chemical compounds such as nicotine, coumarin, and tobacco-specific nitrosamine. Several of these compounds have been recognized as procarcinogens activated by CYP2A13. We recently s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4c82b7ed87fdcdfc7de877477affb4
https://pubmed.ncbi.nlm.nih.gov/29342418

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