Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Hiroki, Sugishita"'
Autor:
Yu Hashimoto, Yoshio Tokumoto, Takao Watanabe, Yusuke Ogi, Hiroki Sugishita, Satoshi Akita, Kazuki Niida, Mirai Hayashi, Masaya Okada, Kana Shiraishi, Kazuhiro Tange, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Taro Oshikiri, Yoichi Hiasa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Double-stranded RNA-activated protein kinase R (PKR) is highly expressed in colorectal cancer (CRC). However, the role of PKR in CRC remains unclear. The aim of this study was to clarify whether C16 (a PKR inhibitor) exhibits antitumor effec
Externí odkaz:
https://doaj.org/article/e06ff7febde044f0ac638efddc24847e
Autor:
Yusuke Ogi, Hiroyuki Egi, Kei Ishimaru, Shigehiro Koga, Motohira Yoshida, Satoshi Kikuchi, Satoshi Akita, Hiroki Sugishita, Hironori Matsumoto, Tetsuya Shimokawa, Akihide Takeuchi, Yuji Watanabe
Publikováno v:
World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-8 (2023)
Abstract Background Laparoscopic and robotic surgery for transverse colon cancer are difficult due to complex fusion of the foregut and midgut and variation of the vessels of the transverse colon. Although the vessels of the right colon have been inv
Externí odkaz:
https://doaj.org/article/661c18caffc145acb88c41fd9dcec85e
Autor:
Hiroki Sugishita, Takashi Kondo, Shinsuke Ito, Manabu Nakayama, Nayuta Yakushiji-Kaminatsui, Eiryo Kawakami, Yoko Koseki, Yasuhide Ohinata, Jafar Sharif, Mio Harachi, Neil P. Blackledge, Robert J. Klose, Haruhiko Koseki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Polycomb repressive complexes (PRC1 and PRC2) repress genes that are crucial for development via epigenetic modifications; however, their role in differentiation is not well known. Here the authors reveal that a PCGF1-containing PRC1 variant facilita
Externí odkaz:
https://doaj.org/article/dee9c656f1d944dab8edc3fb703eee1f
Autor:
Tianyi Hideyuki Shi1 hideyuki@g.ecc.u-tokyo.ac.jp, Hiroki Sugishita1,2, Yukiko Gotoh1,2 ygotoh@mol.f.u-tokyo.ac.jp
Publikováno v:
Journal of Cell Biology. 5/6/2024, Vol. 223 Issue 5, p1-16. 16p.
Autor:
Hikaru Eto, Yusuke Kishi, Nayuta Yakushiji-Kaminatsui, Hiroki Sugishita, Shun Utsunomiya, Haruhiko Koseki, Yukiko Gotoh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
NCOMMS-19-38235B Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of distinct functional regions. Here, the authors find that PcG proteins suppress BMP and Wnt signaling in a region-specific manner, allowing fo
Externí odkaz:
https://doaj.org/article/ce804acfbc32428c8f42eaeed912e0a0
Autor:
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and t
Externí odkaz:
https://doaj.org/article/4842027f92a24fc0962b7e4177ab2cdc
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Epigenome research has employed various methods to identify the genomic location of proteins of interest, such as transcription factors and histone modifications. A recently established method called CUT&Tag uses a Protein-A Tn5 transposase fusion pr
Externí odkaz:
https://doaj.org/article/3254e3df616847a6b2461867e6b27031
Autor:
Kaho Harada, Chika Hasegawa, Taisuke Matsumoto, Hiroki Sugishita, Chitoshi Kitamura, Shuhei Higashibayashi, Masashi Hasegawa, Shuichi Suzuki, Shin-ichiro Kato
Publikováno v:
Chemical Communications. 59:1301-1304
The title compound has a sufficiently persistent radical cationic state and enough chiral stability for optical resolution.
Magnetic microbeads are small iron oxide nanoparticles coated with a bioaffinity material that selectively binds to specific biomolecules of interest, enabling their capture and isolation from complex biological samples. Magnetic microbeads are widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa25abdf2b06b7f48da1b7f568df07c
https://doi.org/10.1101/2023.04.26.538353
https://doi.org/10.1101/2023.04.26.538353
Autor:
Yasuhide Ohinata, Takaho A. Endo, Hiroki Sugishita, Takashi Watanabe, Yusuke Iizuka, Yurie Kawamoto, Atsunori Saraya, Mami Kumon, Yoko Koseki, Takashi Kondo, Osamu Ohara, Haruhiko Koseki
Publikováno v:
Science. 375:574-578
The mammalian blastocyst consists of three distinct cell types: epiblast, trophoblast (TB), and primitive endoderm (PrE). Although embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) retain the functional properties of epiblast and TB, resp