Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Hiroki, Mizukami"'
Autor:
Yutaro Hara, Hiroki Mizukami, Keisuke Yamazaki, Takahiro Yamada, Akiko Igawa, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Kotaro Murakami, Kazuhiro Kudoh, Keinosuke Ishido, Kenichi Hakamada
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 5, Pp 354-366 (2023)
Abstract Diabetes mellitus (DM) is a risk factor for pancreatic ductal adenocarcinoma (PDAC) that promotes the promoter methylation of CDH1. It is still unclear whether DM can exert other epigenetic effects, such as altering microRNA (miR) expression
Externí odkaz:
https://doaj.org/article/49220e3a8e094148a1c67db469d803bb
Autor:
Hiroki Mizukami
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 10, Pp 1157-1159 (2023)
Externí odkaz:
https://doaj.org/article/a0dd45b16ed347faaf80e0b434448b5b
Autor:
Xuekai Pan, Hiroki Mizukami, Yutaro Hara, Takahiro Yamada, Keisuke Yamazaki, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Akiko Igawa, Kenichi Hakamada
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 1, Pp 132-144 (2023)
ABSTRACT Aims/Introduction The mismatch repair (MMR) protein recognizes DNA replication errors and plays an important role in tumorigenesis, including pancreatic ductal adenocarcinoma (PDAC). Although PMS2, a MMR protein, is degraded under oxidative
Externí odkaz:
https://doaj.org/article/6998ae817b84431d853edfa8cde7bac6
Autor:
Yasuo Miki, Yuki Takeuchi, Shingo Murasawa, Shinobu Takayasu, Fumiyasu Tsushima, Shingo Kakeda, Hiroki Mizukami, Koichi Wakabayashi
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-5 (2022)
Abstract Background Neurological symptoms and radiographic abnormalities may remain in a small proportion of patients with metronidazole-induced encephalopathy (MIE). Although experimental animal models of MIE have suggested a Wernicke’s encephalop
Externí odkaz:
https://doaj.org/article/c5bab90961ca4ad1b18b2bdae405c42c
Autor:
Kenta Yoshida, Masaki Yokoyama, Yoshinori Hirao, Yuki Sato, Taro Saito, Yasushi Soma, Hiroki Mizukami, Shisaku Fukuda, Hirotake Sakuraba
Publikováno v:
Clinical Case Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)
Key Clinical Message Bile duct metastasis of breast cancer is rare. It often causes obstructive jaundice which makes the patient interrupt state of treatment. Endoscopic drainage for obstructive jaundice is effective and less invasive treatment optio
Externí odkaz:
https://doaj.org/article/ad36559aad3647d380180dfad120caa0
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1544 (2023)
Reactive oxygen species (ROS) are produced mainly by mitochondrial respiration and function as signaling molecules in the physiological range. However, ROS production is also associated with the pathogenesis of various diseases, including insulin res
Externí odkaz:
https://doaj.org/article/167697ab34a34b48bd9946727a602c32
Autor:
Hiroki Mizukami, Kazuhiro Kudoh
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 1, Pp 6-13 (2022)
ABSTRACT The etiology of type 2 diabetes is multifactorial, in which environmental and genetic factors are involved to varying degrees. This suggests that its pathophysiology might vary depending on the individuals. Knowledge of the differences is cr
Externí odkaz:
https://doaj.org/article/224a8724e03c493b818c33c9d1e7d4b3
Autor:
Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Kazuhiro Kudoh, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2149-2161 (2021)
Abstract Aims/Introduction Islets have microvessels that might develop pathological alterations similar to microangiopathy in type 2 diabetes patients. It remains unclear, however, whether the changes correlate with endocrine cell deficits or whether
Externí odkaz:
https://doaj.org/article/5334ab9d195d4893b04422432831e72f
Autor:
Sho Osonoi, Hiroki Mizukami, Yuki Takeuchi, Hikari Sugawa, Saori Ogasawara, Shizuka Takaku, Takanori Sasaki, Kazuhiro Kudoh, Koichi Ito, Kazunori Sango, Ryoji Nagai, Yasuhiko Yamamoto, Makoto Daimon, Hiroshi Yamamoto, Soroku Yagihashi
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
It is suggested that activation of receptor for advanced glycation end products (RAGE) induces proinflammatory response in diabetic nerve tissues. Macrophage infiltration is invoked in the pathogenesis of diabetic polyneuropathy (DPN), while the asso
Externí odkaz:
https://doaj.org/article/8b94de940bb9438eb3a6b8cf190a6aa7
Autor:
Yuki Takeuchi, Hiroki Mizukami, Kazuhiro Kudoh, Sho Osonoi, Takanori Sasaki, Hanae Kushibiki, Saori Ogasawara, Yutaro Hara, Akiko Igawa, Xuekai Pan, Takahiro Yamada, Keisuke Yamazaki, Tatsuya Mikami, Makoto Daimon, Soroku Yagihashi, Kenichi Hakamada, Shigeyuki Nakaji
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105839- (2022)
Small fibre neuropathy (SFN) is an initial pathology of diabetic polyneuropathy (DPN). Serum lipopolysaccharide binding protein levels are positively correlated with the pain threshold in the foot, suggesting that the abundance of gut Gram-negative b
Externí odkaz:
https://doaj.org/article/804f72b69a584cf08541270d878eeaff