Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hirokazu Ueno"'
Autor:
Kimberly F. Fennell, Zhijun Kang, Hirokazu Ueno, William E. Hoffman, Mihály Hajós, Thomas Allen Chappie, Mary Piotrowski, Noha Maklad, Jayvardhan Pandit, John M. Humphrey, Anne W. Schmidt, Edward X. Yang, Patrick Robert Verhoest, Bethany L. Kormos, Jiemin Lu, Eric P. Arnold, Cheng Chang, Christopher J. Schmidt, Robin J. Kleiman, Rebecca E. O’Connor, John F. Harms, Scot Richard Mente, Christopher John Helal, Tracey Boyden, Chewah Lee, Laura McDowell, Michael D. Forman
Publikováno v:
Journal of Medicinal Chemistry. 60:5673-5698
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify potent PDE2A inhibitors with improved brain pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146c156bc1785305e9a93e6cd8b6147
https://doi.org/10.1021/acs.jmedchem.7b00397
https://doi.org/10.1021/acs.jmedchem.7b00397
Autor:
Christopher J. Helal, Eric P. Arnold, Tracey L. Boyden, Cheng Chang, Thomas A. Chappie, Kimberly F. Fennell, Michael D. Forman, Mihaly Hajos, John F. Harms, William E. Hoffman, John M. Humphrey, Zhijun Kang, Robin J. Kleiman, Bethany L. Kormos, Erik A. LaChapelle, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E. O’Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W. Schmidt, Christopher J. Schmidt, Hirokazu Ueno, Patrick R. Verhoest, Edward X. Yang
Publikováno v:
Journal of medicinal chemistry. 61(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284ec23899d97800205ac23dc80d4562
https://pubmed.ncbi.nlm.nih.gov/28574706
https://pubmed.ncbi.nlm.nih.gov/28574706
Autor:
Mihály Hajós, William E. Hoffman, John F. Harms, Mary Piotrowski, Christopher J. Schmidt, Eric P. Arnold, Robin J. Kleiman, Edward X. Yang, Adam Ogden, Patricia A. Seymour, Jiemin Lu, Ethan Lawrence Fisher, Nichole Vansell, Patrick Robert Verhoest, Jayvardhan Pandit, Zhijun Kang, Hirokazu Ueno, John M. Humphrey, Bethany L. Kormos, Dina McGinnis, Thomas Allen Chappie, Noha Maklad, Laura McDowell, Cheng Chang, Rebecca E. O’Connor, Chewah Lee, Tracey Boyden, Christopher J. O’Donnell, Christopher John Helal
Publikováno v:
Journal of medicinal chemistry. 61(3)
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The analog PF-05180999 (30) was subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408cc7b21c310fe120ce681146fe8fb5
https://pubmed.ncbi.nlm.nih.gov/29293004
https://pubmed.ncbi.nlm.nih.gov/29293004
Autor:
Jimmy Kong, Theunis C. Goosen, Kimberly O. Cameron, Samit Kumar Bhattacharya, Suvi T. M. Orr, Dilinie P. Fernando, Peter Cornelius, Eunsun Lee, Meihua Tu, Stefanus J. Steyn, David Austen Perry, Laura Michael, Jana Polivkova, Ann M. Janssen, Margaret Jackson, Jeffrey T. Kohrt, Ruduan Wang, Sylvie Perez, Hirokazu Ueno, Kimberly Lapham, Dawn Kelly-Sullivan, Victoria Bagdasarian, Roger Swartz, Ingrid A. Stock, Yingxin Zhang, Ryan Jones, Erasga Noe Ouano, Kim F. McClure, Wenhua Jiao, Daniel W. Kung, Guoqiang Wang, Hua Gao, Sam Varma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5410-5414
The optimization for selectivity and central receptor occupancy for a series of spirocyclic azetidine-piperidine inverse agonists of the ghrelin receptor is described. Decreased mAChR muscarinic M2 binding was achieved by use of a chiral indane in pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e6d8033acfd64e2624f92f66f339ad
https://doi.org/10.1016/j.bmcl.2013.07.044
https://doi.org/10.1016/j.bmcl.2013.07.044
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 36:880-886
In cancer chemotherapy,there has recently been a paradigm shift from inpatient to outpatient treatment.Since the outpatient oncology room opened at the National Hospital Organization Fukui Hospital in November 2004,pharmacists have been providing pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::095c91610975146fc82943e4ec3ccd28
https://doi.org/10.5649/jjphcs.36.880
https://doi.org/10.5649/jjphcs.36.880
Publikováno v:
Tetrahedron Letters. 47:89-92
A convergent synthesis of the FGHI ring segment of yessotoxin was achieved via the intramolecular allylation of an α-chloroacetoxy ether and subsequent ring-closing metathesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c60fcbf4ef790320cfa90d17902e1d67
https://doi.org/10.1016/j.tetlet.2005.10.136
https://doi.org/10.1016/j.tetlet.2005.10.136
Autor:
Shigeto Oda, Hidetoshi Shiga, Hiroyuki Hirasawa, Hirokazu Ueno, Kenichi Matsuda, Masataka Nakamura
Publikováno v:
Therapeutic Apheresis and Dialysis. 8:390-397
Continuous hemodiafiltration (CHDF) is an essential procedure in critical care. However, application of this therapy to pediatric patients is associated with several problems derived from their smaller body size and weight compared with adults. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15aa9655f06865976cdf52a521bb3f8
https://doi.org/10.1111/j.1526-0968.2004.00174.x
https://doi.org/10.1111/j.1526-0968.2004.00174.x
Autor:
Hiroyuki Hirasawa, Hirokazu Ueno, Yoh Hirayama, Hidetoshi Shiga, Masataka Nakamura, Kenichi Matsuda, Shigeto Oda
Publikováno v:
Critical Care Medicine. 32:2085-2089
Objective: To investigate whether the release of lipid mediators is suppressed in rats with experimentally induced acute lung injury managed with partial liquid ventilation (PLV) using FC-77. Design: Prospective, randomized controlled study. Setting:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a972f838c707c35efc11df41b86bb0
https://doi.org/10.1097/01.ccm.0000142576.59654.bc
https://doi.org/10.1097/01.ccm.0000142576.59654.bc
Autor:
Kazuya Nakanishi, Hirokazu Ueno, Hiroyuki Hirasawa, Hidetoshi Shiga, Kenichi Matsuda, Shigeto Oda
Publikováno v:
Critical Care Medicine. 30:2242-2248
Until recently, attention has been directed to disseminated intravascular coagulation as a cause of multiple organ failure (MOF). On the other hand, it has now become clear that humoral mediators play important roles in the pathogenesis of MOF. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ca93e97c707458fb1c1ead2878d60b
https://doi.org/10.1097/00003246-200210000-00011
https://doi.org/10.1097/00003246-200210000-00011
Autor:
Eizo Watanabe, Shigeto Oda, Hirokazu Ueno, Nobuya Kitamura, Hidetoshi Shiga, Hiroyuki Hirasawa, Kazuya Nakanishi
Publikováno v:
Nihon Kyukyu Igakukai Zasshi. 13:411-421
われわれはSAPの本態を全身性炎症反応症候群(SIRS)の重症化であるとの考えから,SIRS対策としてのCHDFを中心とする集中治療を施行してきた。SIRSの本態は高cytokine血症であり,なかでもIL-6は
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::832d864e38f59398d60b32cd4d52793d
https://doi.org/10.3893/jjaam.13.411
https://doi.org/10.3893/jjaam.13.411