Výsledky vyhledávání - "Hirokazu Sugimoto"

Autor: Mizuyo Nakamura, Hiroki Nagase, Kyoko Fujiwara, Kiriko Hiraoka, Toshinori Ozaki, Hirokazu Sugimoto, Meixiang Sang, Hiroyuki Yoda

Publikováno v: The Febs Journal

Although runt-related transcription factor 2 (RUNX2) is known to be an essential key transcription factor for osteoblast differentiation and bone formation, RUNX2 also plays a pivotal role in the regulation of p53-dependent DNA damage response. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6786a92416d4bb624324e3585cc4ba2
https://doi.org/10.1111/febs.13108

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Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

Autor: Koji Oda, Kosuke Okada, Hirotoshi Utsunomiya, Keiko Taguchi, Kaoru Ishizaki, Nobuharu Goto, Hirokazu Sugimoto, Junichi Shoda, Jonathan M. Maher, Masayuki Yamamoto, Tetsuro Ishii, Yoshimi Inoue, Eiji Warabi, Makio Ohtsuki

Publikováno v: Biochemical and Biophysical Research Communications. 389:431-436

The transcription factor Nrf2 is a key regulator for hepatic induction of detoxifying enzymes, antioxidative stress genes and Mrp efflux transporters. We aimed to investigate whether Nrf2 activation counteracts liver injury associated with cholestasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacb1f5bf42d4b950352e0beb4b8cece
https://doi.org/10.1016/j.bbrc.2009.08.156

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Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate

Autor: Hirokazu Sugimoto, Yoshiaki Maru, Atsushi Takatori, Hiroki Nagase, Toshikazu Bando, Tadamichi Denda, Takayoshi Watanabe, Kyoko Fujiwara, Nobuko Koshikawa, Allan Balmain, Hiroyuki Yoda, Takahiro Inoue, Hiroshi Sugiyama, Kiriko Hiraoka, Toshinori Ozaki, Ken-ichi Shinohara, Rhys Dylan Taylor

Publikováno v: Nature communications. 6

Despite extensive efforts to target mutated RAS proteins, anticancer agents capable of selectively killing tumour cells harbouring KRAS mutations have remained unavailable. Here we demonstrate the direct targeting of KRAS mutant DNA using a synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0628c489fb56239539d434675865b8d6
https://pubmed.ncbi.nlm.nih.gov/25913614

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Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet

Autor: Hiroshi Takahashi, Junichi Shoda, Hirokazu Sugimoto, Tetsuro Ishii, Naohiro Gotoh, Katsutoshi Tokushige, Kosuke Okada, Masaki Horie, Hirotoshi Utsunomiya, Eiji Warabi, Masayuki Yamamoto, Etsuko Hashimoto

Publikováno v: Journal of gastroenterology. 48(5)

The transcription factor nuclear factor-E2-related factor-2 (Nrf2) inhibits lipid accumulation and oxidative stress in the liver by interfering with lipogenic pathways and inducing antioxidative stress genes.The involvement of Nrf2 in defense against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f4cac7b755df81ffa61934f66c160a
https://pubmed.ncbi.nlm.nih.gov/22972520

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Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

Autor: Tetsuya Ueda, Tetsuro Ishii, Ichinosuke Hyodo, Toru Yanagawa, Kazunori Ishige, Keiko Taguchi, Masayuki Yamamoto, Eiji Warabi, Kosuke Okada, Hirokazu Sugimoto, Akira Nakahara, Junichi Shoda

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 298(2)

Oxidative stress is a critical mediator in liver injury of steatohepatitis. The transcription factor Nrf2 serves as a cellular stress sensor and is a key regulator for induction of hepatic detoxification and antioxidative stress systems. The involvem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf1a9f1b5d6f8944c6412b4fbd96a8
https://pubmed.ncbi.nlm.nih.gov/19926817

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The Team Description of the Team OMNI

Autor: Dong Pyo Kim, Fumio Miyazaki, Yukihisa Tanaka, Junichi Ieda, Hirokazu Sugimoto, Nobuhito Mori, Tomoya Usui, Yasuhiro Masutani, Ryouhei Fujimoto, Daisuke Sekimori, Masaya Enomoto, Tetsuhiro Maeda, Wataru Matsui, Osamu Miyake

Publikováno v: RoboCup 2001: Robot Soccer World Cup V ISBN: 9783540439127
RoboCup

The Team OMNI has developed a robot system with omni-directional vision and omni-directional mobility according to the rule of the RoboCup Small Size League. This paper describes the hardware configuration, software configuration, and simulator of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20c69099fde1bede105ccc91f44ed7ad
https://doi.org/10.1007/3-540-45603-1_93

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