Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Hirokazu Shigematsu"'
Autor:
Hirokazu Shigematsu, Masaki Yamato, Hiroyuki Takahama, Shoji Sanada, Yoshihiro Asano, Masafumi Kitakaze, Naoto Oku, Hai Ying Fu, Issei Komuro, Tetsuo Minamino, Tomohiro Asai, Hiroshi Asanuma, Keiji Okuda, Masanori Asakura, Takashi Matsuzaki
Publikováno v:
Cardiovascular Drugs and Therapy. 27:125-132
Although amiodarone is recognized as the most effective anti-arrhythmic drug available, it has negative hemodynamic effects. Nano-sized liposomes can accumulate in and selectively deliver drugs to ischemic/reperfused (I/R) myocardium, which may augme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e166c611a47f16237d4eca6b4d08d1
https://doi.org/10.1007/s10557-012-6437-6
https://doi.org/10.1007/s10557-012-6437-6
Autor:
Kosuke Shimizu, Eisuke Mekada, Naoto Oku, Hisakazu Kato, Kaoru Nishikawa, Hirokazu Shigematsu, Tetsuo Minamino, Yoshihiro Asano, Seiji Takashima, Tomohiro Asai
Publikováno v:
Journal of Controlled Release. 160:274-280
Increased expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) is frequently observed in certain cancers such as ovarian and breast cancers, and this protein is a desirable target for drug delivery by a drug delivery syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31268fbde071b855384b0718044ccfb
https://doi.org/10.1016/j.jconrel.2011.10.010
https://doi.org/10.1016/j.jconrel.2011.10.010
Autor:
Susan Bonner-Weir, Shigeru Yatoh, Hirokazu Shigematsu, Koichi Akashi, Gordon C. Weir, Hiromi Iwasaki, Yoshiyuki Hamamoto, Tomoyuki Akashi
Publikováno v:
Diabetes/Metabolism Research and Reviews. 24:585-590
Background In this study, we carried out bone marrow and foetal liver cell transplantation to determine if these cells could differentiate into pancreatic β-cells or promote regeneration. Methods To exclude an artificial or immunological influence f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4214b89242faddd131aa0f6196d4e4
https://doi.org/10.1002/dmrr.884
https://doi.org/10.1002/dmrr.884
Autor:
Yong Chong, Thomas Graf, Yojiro Arinobu, Philippe Kastner, Robin Mayfield, Tadafumi Iino, Koichi Akashi, Hirokazu Shigematsu, Shinichi Mizuno, Hiromi Iwasaki, Susan Chan
Publikováno v:
Cell Stem Cell. 1:416-427
Summary A hierarchical hematopoietic development with myeloid versus lymphoid bifurcation has been proposed downstream of the multipotent progenitor (MPP) stage, based on prospective isolation of progenitors capable of generating only myeloerythroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd1fdd64654cd1999e70568a480ca2b
https://doi.org/10.1016/j.stem.2007.07.004
https://doi.org/10.1016/j.stem.2007.07.004
Autor:
Giorgio Cattoretti, Takahiro Maeda, Taha Merghoub, Koichi Akashi, Pier Paolo Pandolfi, Hirokazu Shigematsu, Marcel R.M. van den Brink, Arthur Zelent, Julie Teruya-Feldstein, Manami Maeda, Lin Dong, Robin M. Hobbs, Johannes L. Zakrzewski
Publikováno v:
Science. 316:860-866
Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8048846c9441853cbc78f0928d4e08
https://doi.org/10.1126/science.1140881
https://doi.org/10.1126/science.1140881
Autor:
Ifor R. Williams, Dana E. Cullen, Koichi Akashi, Hirokazu Shigematsu, Olivier Bernard, D. Gary Gilliland, Glen D. Raffel, Thomas Mercher
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6001-6006
OTT1 ( RBM15 ) was originally described as a 5′ translocation partner of the MAL ( MKL1 ) gene in t( 1 , 22 )(p13;q13) infant acute mega karyocytic leukemia. OTT1 has no established physiological function, but it shares homology with the spen / Min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efa77edc0d531dcfd0fac221fb40111
https://doi.org/10.1073/pnas.0609041104
https://doi.org/10.1073/pnas.0609041104
Autor:
Shinichi Mizuno, Yojiro Arinobu, Hirokazu Shigematsu, Daniel G. Tenen, Yasuo Mori, Kiyoshi Takatsu, Hidetoshi Ozawa, Koichi Akashi, Hiromi Iwasaki
Publikováno v:
Genes & Development. 20:3010-3021
The mechanism of lineage specification in multipotent stem cells has not been fully understood. We recently isolated progenitors with the eosinophil, basophil, or mast cell lineage potential, all of which originate from granulocyte/monocyte progenito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5094316932f7ee981202daadc932be3f
https://doi.org/10.1101/gad.1493506
https://doi.org/10.1101/gad.1493506
Autor:
D. Gary Gilliland, Timothy J. Ley, Ifor R. Williams, Jeffery L. Kutok, Michelle M. Le Beau, Koichi Akashi, Sandra A. Moore, Iris T. Chan, Sarah L. Cohen, Hirokazu Shigematsu
Publikováno v:
Blood. 108:1708-1715
Most patients with acute promyelocytic leukemia (APL) express PML-RAR alpha, the fusion product of t(15;17)(q22;q11.2). Transgenic mice expressing PML-RAR alpha develop APL with long latency, low penetrance, and acquired cytogenetic abnormalities. Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee8c6b8d2ba28655600e9b27f603381
https://doi.org/10.1182/blood-2006-04-015040
https://doi.org/10.1182/blood-2006-04-015040
Autor:
Pu Zhang, Koichi Akashi, Hirokazu Shigematsu, Elena Levantini, Julie A. Lekstrom-Himes, Hiromi Iwasaki, Daniel G. Tenen, Junko Iwasaki-Arai, Bronwyn M. Owens, Tajhal Dayaram, Maris Fenyus, Claudia S. Huettner
Publikováno v:
Immunity. 21:853-863
The transcription factor C/EBP alpha is required for granulopoiesis and frequently disrupted in human acute myeloid leukemia (AML). Here, we show disruption of C/EBP alpha blocks the transition from the common myeloid to the granulocyte/monocyte prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27a1b5812b02c3bcee740becfbf725f
https://doi.org/10.1016/j.immuni.2004.11.006
https://doi.org/10.1016/j.immuni.2004.11.006
Autor:
Qunyan Yu, Shoumo Bhattacharya, Ewa Sicinska, Katarzyna Kozar, Maria A. Ciemerych, Roderick T. Bronson, Agnieszka Zagozdzon, Hirokazu Shigematsu, Koichi Akashi, Piotr Sicinski, Yan Geng, Vivienne I. Rebel
Publikováno v:
Cell. 118:477-491
D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ee08a1db4d394ef60cfbdcdf22d613
https://doi.org/10.1016/j.cell.2004.07.025
https://doi.org/10.1016/j.cell.2004.07.025