Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Hirokazu Kouzuki"'
Autor:
Hiroto, Ohtake, Yasuharu, Tokuyoshi, Yosuke, Iyama, Takumi, Nukaga, Hayato, Nishida, Toshiyuki, Ohtake, Morihiko, Hirota, Kohei, Yamada, Yoshiki, Seto, Hideyuki, Sato, Hirokazu, Kouzuki, Satomi, Onoue
Publikováno v:
The Journal of Toxicological Sciences. 47:483-492
A reactive oxygen species (ROS) assay has been widely used for photosafety assessment; however, the phototoxic potential of complex materials, including plant extracts, essential oils, and functional polymers, is unevaluable because of their undefine
Publikováno v:
The Journal of Toxicological Sciences. 45:95-108
We present a systematic, comprehensive and reproducible weight-of-evidence approach for predicting the no-observed-adverse-effect level (NOAEL) for systemic toxicity by using read-across and quantitative structure-activity relationship (QSAR) models
Autor:
Junko Yamane, Takumi Wada, Hironori Otsuki, Koji Inomata, Mutsumi Suzuki, Tomoka Hisaki, Shuichi Sekine, Hirokazu Kouzuki, Kenta Kobayashi, Hideko Sone, Jun K. Yamashita, Mitsujiro Osawa, Megumu K. Saito, Wataru Fujibuchi
Publikováno v:
iScience. 25(7)
An alternative model that reliably predicts human-specific toxicity is necessary because the translatability of effects on animal models for human disease is limited to context. Previously, we developed a method that accurately predicts developmental
Autor:
Shuichi Sekine, Takumi Wada, Hirokazu Kouzuki, Mitsujiro Osawa, Junko Yamane, Kenta Kobayashi, Hironori Otsuki, Tomoka Hisaki, Koji Inomata, Wataru Fujibuchi, Hideko Sone, Mutsumi Suzuki, Jun K. Yamashita, Megumu K. Saito
SUMMARYThe assessment of toxic chemicals using animals has limited applicability to humans. Moreover, from the perspective of animal protection, effective alternatives are also desired. Previously, we developed a method that combines developmental to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c54635cbadf060dbb6633d1d647208bb
https://doi.org/10.1101/2021.11.05.466718
https://doi.org/10.1101/2021.11.05.466718
Autor:
Kazuhiro Hosoi, Takao Ashikaga, Hiroshi Onodera, Hirokazu Kouzuki, Akemi Toyoda, Hajime Kojima, Satomi Onoue, Osamu Fueki
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 141(1)
Phototoxicity is a toxic response elicited by topically applied or systemically administered photoreactive chemicals after exposure to light and can be broadly categorized into photoirritation, photoallergy, photogenotoxicity, and photocarcinogenicit
Autor:
Atsushi Kodama, Moemi Kawaguchi, Hirokazu Kouzuki, Morihiko Hirota, Kousei Ito, Takumi Nukaga, Akinori Takemura, Shuichi Sekine, Shiho Oeda, Takeshi Susukida
Publikováno v:
Toxicology and applied pharmacology. 394
Drug-induced liver injury (DILI) can cause hepatic failure and result in drug withdrawal from the market. It has host-related and compound-dependent mechanisms. Preclinical prediction of DILI risk is very challenging and safety assessments based on a
Autor:
Hirokazu Kouzuki, Hayato Nishida, Yoshiki Seto, Toshiyuki Ohtake, Yoshiki Tokura, Satomi Onoue, Morihiko Hirota, Takao Ashikaga
Publikováno v:
Toxicology in Vitro. 77:105245
Several non-animal testing methods to assess photoallergic potential have been developed so far, while none of them have yet to be validated and regulatory accepted. Currently, some photoreactivity assays such as UV-VIS spectral analysis and ROS assa
Publikováno v:
Journal of Applied Toxicology. 38:514-526
It is important to predict the potential of cosmetic ingredients to cause skin sensitization, and in accordance with the European Union cosmetic directive for the replacement of animal tests, several in vitro tests based on the adverse outcome pathwa
Autor:
Hayato Nishida, Hirokazu Kouzuki, Shiho Oeda, Setsuya Aiba, Takao Ashikaga, Yoshiki Tokura, Hitoshi Sasa, Morihiko Hirota
Publikováno v:
The Journal of Toxicological Sciences. 41:129-142
As a part of our studies to develop a cell-based in vitro photosensitization assay, we examined whether changes of cell-surface thiols and amines on human monocytic cell line THP-1 could be used to predict photosensitizing potential of chemicals. Fir
Autor:
Yoshiki Tokura, Tomomi Atobe, Kyoko Tsujita-Inoue, Morihiko Hirota, Hirokazu Kouzuki, Takao Ashikaga
Publikováno v:
Journal of Applied Toxicology. 36:956-968
Although photoallergens require UV energy for antigen formation, the subsequent immune response is considered to be the same as in ordinary skin sensitization. Therefore, in vitro tests for skin sensitization should also be applicable for photoallerg