Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Hirokazu Koseki"'
Autor:
Tomoki Kasai, Hirokazu Koseki, Hiroyuki Takao, Soichiro Fujimura, Naoki Kato, Issei Kan, Shota Sunami, Kazuya Yuzawa, Hayato Uchikawa, Toshihiro Ishibashi, Koji Fukudome, Makoto Yamamoto, Yuichi Murayama
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 3, Iss S1 (2023)
Introduction Hemodynamics has been reported to be involved in the pathophysiology of the initiation of intracranial aneurysms. Computational fluid dynamics (CFD) simulation has been widely used to investigate what kind of hemodynamics is related to i
Externí odkaz:
https://doaj.org/article/83f743fb7b6e449c9c85a7de2b17ced6
Autor:
Yu Abekura, Isao Ono, Akitsugu Kawashima, Katsumi Takizawa, Hirokazu Koseki, Haruka Miyata, Kampei Shimizu, Mieko Oka, Mika Kushamae, Susumu Miyamoto, Hiroharu Kataoka, Akira Ishii, Tomohiro Aoki
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background As subarachnoid hemorrhage due to rupture of an intracranial aneurysm (IA) has quite a poor outcome despite of an intensive medical care, development of a novel treatment targeting unruptured IAs based on the correct understanding
Externí odkaz:
https://doaj.org/article/b7d0ea03ebbb4dcdb6bb0fa78a2ff213
Autor:
Tomohiro Aoki, Hirokazu Koseki, Haruka Miyata, Masayoshi Itoh, Hideya Kawaji, Katsumi Takizawa, Akitsugu Kawashima, Hiroshi Ujiie, Takashi Higa, Kenzo Minamimura, Toshikazu Kimura, Hidetoshi Kasuya, Kazuhiko Nozaki, Akio Morita, Hirotoshi Sano, Shuh Narumiya
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Intracranial aneurysm (IA) is a socially important disease as a major cause of subarachnoid hemorrhage. Recent experimental studies mainly using animal models have revealed a crucial role of macrophage-mediated chronic inflammatory responses
Externí odkaz:
https://doaj.org/article/42132f10b4824a308c245646ef9a229d
Autor:
Soichiro, Fujimura, Kazutoshi, Tanaka, Hiroyuki, Takao, Takuma, Okudaira, Hirokazu, Koseki, Akiko, Hasebe, Takashi, Suzuki, Yuya, Uchiyama, Toshihiro, Ishibashi, Katharina, Otani, Kostadin, Karagiozov, Koji, Fukudome, Motoharu, Hayakawa, Makoto, Yamamoto, Yuichi, Murayama
Publikováno v:
Journal of Neurosurgery. 137:335-343
OBJECTIVE Relationships between aneurysm initiation and hemodynamic factors remain unclear since de novo aneurysms are rarely observed. Most previous computational fluid dynamics (CFD) studies have used artificially reproduced vessel geometries befor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57b2f4bdfbb3a257b216f94eea7f92e
https://doi.org/10.3171/2021.8.jns211452
https://doi.org/10.3171/2021.8.jns211452
Autor:
Haruka Miyata, Hirokazu Koseki, Katsumi Takizawa, Hidetoshi Kasuya, Kazuhiko Nozaki, Shuh Narumiya, Tomohiro Aoki
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175421 (2017)
Given the social importance of intracranial aneurysm as a major cause of a lethal subarachnoid hemorrhage, clarification of mechanisms underlying the pathogenesis of this disease is essential for improving poor prognosis once after rupture. Previous
Externí odkaz:
https://doaj.org/article/913425bbd7314a209785af410bad8b0d
Autor:
Akihiro, Okada, Hirokazu, Koseki, Isao, Ono, Tomomichi, Kayahara, Hiroki, Kurita, Susumu, Miyamoto, Hiroharu, Kataoka, Tomohiro, Aoki
Background Considered with the devastating outcome of subarachnoid hemorrhage due to rupture of intracranial aneurysm (IA), a novel therapeutic strategy based on the pathogenesis of IAs should be established. Recent experimental studies have defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a679326733758f0b12cce6cc3f9a71a3
https://doi.org/10.21203/rs.3.rs-1756113/v1
https://doi.org/10.21203/rs.3.rs-1756113/v1
Autor:
Susumu Miyamoto, Hirokazu Koseki, Hirohiko Imai, Hiroharu Kataoka, Mieko Oka, Kampei Shimizu, Tomohiro Aoki, Isao Ono, Masanori Nakamura, Haruka Miyata, Tomohiro Yamada, Yu Abekura, Yuto Yamamoto, Mika Kushamae
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 80:79-88
Past studies have elucidated the crucial role of macrophage-mediated inflammation in the growth of intracranial aneurysms (IAs), but the contributions of hemodynamics are unclear. Considering the size of the arteries, we induced de novo aneurysms at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c69ce8dd0d5e9c5372ba7afc996bf6
https://doi.org/10.1093/jnen/nlaa131
https://doi.org/10.1093/jnen/nlaa131
Autor:
Kampei Shimizu, Satoshi Shimo, Mieko Oka, Tomohiro Aoki, Kazuhiko Nozaki, Isao Ono, Nobuhiko Ohno, Hirokazu Koseki, Hirohiko Imai, Mika Kushamae, Haruka Miyata, Takakazu Kawamata, Yu Abekura, Akitsugu Kawashima
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Smooth muscle cells (SMCs) are the major type of cells constituting arterial walls and play a role to maintain stiffness via producing extracellular matrix. Here, the loss and degenerative changes of SMCs become the major histopathological features o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49304dc26a64873917103fba4b73b4f
http://link.springer.com/article/10.1038/s41598-020-65361-x
http://link.springer.com/article/10.1038/s41598-020-65361-x
Autor:
Kyoichi Tomoto, Yohei Yamamoto, Toshihide Tanaka, Tomoya Suzuki, Akihiko Teshigawara, Jun Takei, Hirokazu Koseki, Ryosuke Mori, Yasuharu Akasaki, Yuichi Murayama
Publikováno v:
Neuro-Oncology Advances. 4:iii8-iii8
Background Since phase 3 randomized clinical trials failed to show the benefit of bevacizumab(Bev) from the induction therapy, Bev was widely used for the recurrence glioblastoma(GBM) cases. Given that Bev treatment for newly diagnosed GBM(nd-GBM) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830d6657323f2ad3b1889596af05991f
https://doi.org/10.1093/noajnl/vdac167.029
https://doi.org/10.1093/noajnl/vdac167.029
Autor:
Yasuharu Akasaki, Tomoya Suzuki, Jun Takei, Toshihide Tanak, Ryosuke Mori, Hirokazu Koseki, Yohei Yamamoto, Akihiko Teshigawara, Yuko Kamata, Takaaki Yanagisawa, Yuichi Murayama
Publikováno v:
Neuro-Oncology Advances. 4:iii12-iii12
Since a diffuse midline glioma (DMG) has no effective therapy, it is an urgent need to develop new therapeutic strategy. We performed immunotherapy using fusions of autologous dendritic cells (DC) with tumor cells in DMG cases in which tumor tissue w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a88d32cb8e1a7fde535dd630969b6d
https://doi.org/10.1093/noajnl/vdac167.042
https://doi.org/10.1093/noajnl/vdac167.042