Výsledky vyhledávání - "Hirokazu Ishikawa"

Akademický článek

Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation

Autor: Kazuhiko Namekata, Naoki Tsuji, Xiaoli Guo, Euido Nishijima, Sari Honda, Yuta Kitamura, Atsushi Yamasaki, Masamichi Kishida, Jun Takeyama, Hirokazu Ishikawa, Youichi Shinozaki, Atsuko Kimura, Chikako Harada, Takayuki Harada

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-8 (2023)

Abstract Dedicator of cytokinesis 3 (DOCK3) is an atypical member of the guanine nucleotide exchange factors (GEFs) and plays important roles in neurite outgrowth. DOCK3 forms a complex with Engulfment and cell motility protein 1 (Elmo1) and effectiv

Externí odkaz: https://doaj.org/article/2c0459c1ded845d2905aa9f9482ad0c3

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Akademický článek

Patritumab deruxtecan (HER3-DXd), a novel HER3 directed antibody drug conjugate, exhibits in vitro activity against breast cancer cells expressing HER3 mutations with and without HER2 overexpression

Autor: Kumiko Koyama, Hirokazu Ishikawa, Manabu Abe, Yoshinobu Shiose, Suguru Ueno, Yang Qiu, Kenji Nakamaru, Masato Murakami

Publikováno v: PLoS ONE, Vol 17, Iss 5 (2022)

ErbB3 (HER3), a member of the HER family, is overexpressed in various cancers and plays an important role in cell proliferation and survival. Certain HER3 mutations have also been identified as oncogenic drivers, making them potential therapeutic tar

Externí odkaz: https://doaj.org/article/c5db8888d872468a953ab15144af6a21

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Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells

Autor: Kenichi Wakita, Shingo Noguchi, Hirokazu Ishikawa, Fumio Matsuda, Hiroshi Shimizu

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

Fumarate hydratase (FH) is an enzyme in the tricarboxylic acid (TCA) cycle, biallelic loss-of-function mutations of which are associated with hereditary leiomyomatosis and renal cell cancer. However, how FH defect modulates intracellular metabolic fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244c4880711eef5653300079e0736089
http://link.springer.com/article/10.1038/s41598-020-70000-6

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Abstract 5201: U3-1402, a novel HER3-targeting antibody-drug conjugate, exhibits in vitro antitumor activity against breast cancer cells expressing HER3 mutations without dependence on HER2 overexpression

Autor: Yoshinobu Shiose, Suguru Ueno, Manabu Abe, Kenji Nakamaru, Hirokazu Ishikawa, Kumiko Koyama, Masato Murakami

Publikováno v: Cancer Research. 80:5201-5201

Background: U3-1402, a novel HER3-targeting antibody-drug conjugate (ADC) composed of a fully human anti-HER3 antibody (patritumab), tetrapeptide-based linker, and topoisomerase I inhibitor payload, is currently being studied in clinical trials for p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3516b968359b6ec4d84b50144d8f819a
https://doi.org/10.1158/1538-7445.am2020-5201

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Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist

Autor: Kiyoshi Arai, Yuka Morikawa, Tsuyoshi Homma, Naoko Ubukata, Toshio Sada, Hiyoyuki Tsuruoka, Hirokazu Ishikawa, Makoto Mizuno, Aoki Kazumasa

Publikováno v: European Journal of Pharmacology. 761:226-234

The present study was designed to characterize the pharmacological profile of CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist. In the radioligand-binding assay, CS-3150 inhibited (3)H-aldosterone binding to mineralocorticoid rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78910e98e4871ddb9a2278da4b92843b
https://doi.org/10.1016/j.ejphar.2015.06.015

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Bovine 5-Oxo-L-Prolinase: Simple Assay Method, Purification, cDNA Cloning, and Detection of mRNA in the Coronary Artery

Autor: Yasuteru Iijima, Hirokazu Ishikawa, Koji Abe, Tohru Watanabe

Publikováno v: Biological and Pharmaceutical Bulletin. 27:288-294

RS-7897 is a novel antianginal nitrate containing an L-2-oxothiazolidine-4-carboxylic acid (OTCA) and unlike other organic nitrates does not induce nitrate tolerance. OTCA is known to be converted to L-cysteine (L-Cys) by rat 5-oxo-prolinase (5-OPase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb9260309fc81bb73a36c92e17ee94a
https://doi.org/10.1248/bpb.27.288

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An angiotensin II type 1 receptor antagonist, olmesartan medoxomil, improves experimental liver fibrosis by suppression of proliferation and collagen synthesis in activated hepatic stellate cells

Autor: Hirokazu Ishikawa, Shoko Kuroda, Miwa Suga, Keisuke Yamada, Nobuya Kurikawa

Publikováno v: British Journal of Pharmacology. 139:1085-1094

We studied the effect of a new angiotensin II type 1 (AT1) receptor antagonist, olmesartan medoxomil (olmesartan), on the fibrogenic responses in rat hepatic stellate cells (HSCs) and liver fibrogenesis. Olmesartan (1 mg kg−1 per day) was orally ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12694fee5f79c1dbdcdde8bd18af079a
https://doi.org/10.1038/sj.bjp.0705339

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