Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Hirokazu Hirai"'
Autor:
Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/c675f44c5e9540f9bb98a8df88237141
Autor:
Keita Kinoshita, Kensuke Motomura, Keisuke Ushida, Yuma Hirata, Ayumu Konno, Hirokazu Hirai, Shunsuke Kotani, Natsuko Hitora-Imamura, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00370- (2024)
Hemorrhage-induced injury of the corticospinal tract (CST) in the internal capsule (IC) causes severe neurological dysfunction in both human patients and rodent models of intracerebral hemorrhage (ICH). A nuclear receptor Nurr1 (NR4A2) is known to ex
Externí odkaz:
https://doaj.org/article/5ca566014b614774ad88d7de781b319a
Autor:
Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Hirokazu Hirai
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101185- (2024)
The production of cell-type– and age-specific genetically modified mice is a powerful approach for unraveling unknown gene functions. Here, we present a simple and timesaving method that enables adeno-associated virus (AAV)–mediated cell-type–
Externí odkaz:
https://doaj.org/article/bb4617befc7e4be2be82205b44e86479
Autor:
Masashi Watanave, Mika Kawachi, Ayumu Konno, Ryo Aoki, Yuuki Fukai, Yasunori Matsuzaki, Ryosuke Kaneko, Hirokazu Hirai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Protein kinase C γ (PKCγ), a neuronal isoform present exclusively in the central nervous system, is most abundantly expressed in cerebellar Purkinje cells (PCs). Targeted deletion of PKCγ causes a climbing fiber synapse elimination in developing P
Externí odkaz:
https://doaj.org/article/f83b2856c047493d899fdaba4502e8cb
Production of Spinocerebellar Ataxia Type 3 Model Mice by Intravenous Injection of AAV-PHP.B Vectors
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7205 (2024)
We aimed to produce a mouse model of spinocerebellar ataxia type 3 (SCA3) using the mouse blood–brain barrier (BBB)-penetrating adeno-associated virus (AAV)-PHP.B. Four-to-five-week-old C57BL/6 mice received injections of high-dose (2.0 × 1011 vg/
Externí odkaz:
https://doaj.org/article/6da3aff01b2e4481bb50316fbac6750e
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 81-92 (2023)
Upon systemic administration, adeno-associated virus serotype 9 (AAV9) and the capsid variant PHP.eB show distinct tropism for the central nervous system (CNS), whereas AAV2 and the capsid variant BR1 transduce brain microvascular endothelial cells (
Externí odkaz:
https://doaj.org/article/9117a610e37f4fb2a735e6891214aaf2
Autor:
Mieko Morishima, Sohta Matsumura, Suguru Tohyama, Takashi Nagashima, Ayumu Konno, Hirokazu Hirai, Ayako M. Watabe
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The amygdala plays a crucial role in aversive learning. In Pavlovian fear conditioning, sensory information about an emotionally neutral conditioned stimulus (CS) and an innately aversive unconditioned stimulus is associated with the lateral amygdala
Externí odkaz:
https://doaj.org/article/7f2aa61a902d42e8835adf9d154aaa0a
Autor:
Takashi Nagashima, Kaori Mikami, Suguru Tohyama, Ayumu Konno, Hirokazu Hirai, Ayako M. Watabe
Publikováno v:
Frontiers in Neural Circuits, Vol 17 (2023)
Appropriately responding to various sensory signals in the environment is essential for animal survival. Accordingly, animal behaviors are closely related to external and internal states, which include the positive and negative emotional values of se
Externí odkaz:
https://doaj.org/article/9568a7be92da4b348b9559bf738f112f
Autor:
Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hirai
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Microglia-targeting AAV vectors are created which can be utilized to study microglial pathophysiology and microglia-targeted therapies in mice, especially in the regions of striatum and cerebellar cortex.
Externí odkaz:
https://doaj.org/article/fc353f775a7747808482b001c05a904a
Autor:
Mingyue Jin, Sakiko Matsumoto, Takashi Ayaki, Hodaka Yamakado, Tomoyuki Taguchi, Natsuko Togawa, Ayumu Konno, Hirokazu Hirai, Hiroshi Nakajima, Shoji Komai, Ryuichi Ishida, Syuhei Chiba, Ryosuke Takahashi, Toshifumi Takao, Shinji Hirotsune
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In this work, the authors show that α-synuclein is posttranslationally dopanized at Tyr136 by tyrosine hydroxylase, which facilitates the formation of oligomers. This modification likely impacts pathogenesis and the selective degeneration of dopamin
Externí odkaz:
https://doaj.org/article/ed3bba349ad1462fa25323761da6c9f0