Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Hirohito Sasaki"'
1
Akademický článek
Syk inhibitors reduce tau protein phosphorylation and oligomerization
Autor: Tomohisa Yamaguchi, Tadanori Hamano, Kiyonao Sada, Rei Asano, Nicholas M. Kanaan, Hirohito Sasaki, Shu-Hui Yen, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Koji Aoki, Hironobu Naiki, Maho Morishima, Yuko Saito, Shigeo Murayama, Yasunari Nakamoto
Publikováno v: Neurobiology of Disease, Vol 201, Iss , Pp 106656- (2024)
Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed. We evaluated the localization of Syk in the brains of patients with
Externí odkaz: https://doaj.org/article/239a93f919264675ad69ceb404dfc1d2
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2
Akademický článek
Posterior reversible encephalopathy syndrome (PRES) associated with SARS-CoV-2 infection in a patient under maintenance haemodialysis: a case report
Autor: Yuki Shimamoto, Hirohito Sasaki, Kenji Kasuno, Yuki Watanabe, Sayumi Sakashita, Sho Nishikawa, Kazuhisa Nishimori, Sayu Morita, Yudai Nishikawa, Mamiko Kobayashi, Sachiko Fukushima, Soichi Enomoto, Naoki Takahashi, Tadanori Hamano, Ippei Sakamaki, Hiromichi Iwasaki, Masayuki Iwano
Publikováno v: BMC Nephrology, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Background Endothelial dysfunction is common in patients undergoing chronic haemodialysis, and is a major cause of posterior reversible encephalopathy syndrome (PRES). Recently, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ha
Externí odkaz: https://doaj.org/article/ef8009fecb134758b36776ffe57bc8bc
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3
Akademický článek
Magnetic resonance imaging arterial spin labeling hypoperfusion with diffusion-weighted image hyperintensity is useful for diagnostic imaging of Creutzfeldt–Jakob disease
Autor: Yuki Kitazaki, Masamichi Ikawa, Tadanori Hamano, Hirohito Sasaki, Tomohisa Yamaguchi, Soichi Enomoto, Norimichi Shirafuji, Kouji Hayashi, Osamu Yamamura, Tetsuya Tsujikawa, Hidehiko Okazawa, Hirohiko Kimura, Yasunari Nakamoto
Publikováno v: Frontiers in Neurology, Vol 14 (2023)
Background and objectivesMagnetic resonance imaging with arterial spin labeling (ASL) perfusion imaging is a noninvasive method for quantifying cerebral blood flow (CBF). We aimed to evaluate the clinical utility of ASL perfusion imaging to aid in th
Externí odkaz: https://doaj.org/article/6572d88d913a4529bdbdb2314cc61ba7
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4
Akademický článek
Metabolic changes in the plasma of mild Alzheimer’s disease patients treated with Hachimijiogan
Autor: Mosaburo Kainuma, Shinobu Kawakatsu, Jun-Dal Kim, Shinji Ouma, Osamu Iritani, Ken-Ichiro Yamashita, Tomoyuki Ohara, Shigeki Hirano, Shiro Suda, Tadanori Hamano, Sotaro Hieda, Masaaki Yasui, Aoi Yoshiiwa, Seiji Shiota, Masaya Hironishi, Kenji Wada-Isoe, Daiki Sasabayashi, Sho Yamasaki, Masayuki Murata, Kouta Funakoshi, Kouji Hayashi, Norimichi Shirafuji, Hirohito Sasaki, Yoshinori Kajimoto, Yukiko Mori, Michio Suzuki, Hidefumi Ito, Kenjiro Ono, Yoshio Tsuboi
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
Background: Alzheimer’s disease (AD), the most prevalent form of dementia, is a debilitating, progressive neurodegeneration. Amino acids play a wide variety of physiological and pathophysiological roles in the nervous system, and their levels and d
Externí odkaz: https://doaj.org/article/22b6495c96ca47959b8406562eb0533d
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5
Akademický článek
An exploratory, open-label, randomized, multicenter trial of hachimijiogan for mild Alzheimer’s disease
Autor: Mosaburo Kainuma, Shinji Ouma, Shinobu Kawakatsu, Osamu Iritani, Ken-Ichiro Yamashita, Tomoyuki Ohara, Shigeki Hirano, Shiro Suda, Tadanori Hamano, Sotaro Hieda, Masaaki Yasui, Aoi Yoshiiwa, Seiji Shiota, Masaya Hironishi, Kenji Wada-Isoe, Daiki Sasabayashi, Sho Yamasaki, Masayuki Murata, Kouta Funakoshi, Kouji Hayashi, Norimichi Shirafuji, Hirohito Sasaki, Yoshinori Kajimoto, Yukiko Mori, Michio Suzuki, Hidefumi Ito, Kenjiro Ono, Yoshio Tsuboi
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Background: Alzheimer’s disease (AD) is a progressive neurodegeneration and is the most prevalent form of dementia. Intervention at an early stage is imperative. Although three acetylcholinesterase inhibitors (AChEIs) are currently approved for the
Externí odkaz: https://doaj.org/article/c42f211f57f44f7ab0b6bb5eaf4f1a6d
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8
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein
Autor: Feiyan Zhu, Shu-Hui Yen, Nicholas M. Kanaan, Hirohito Sasaki, Norimichi Shirafuji, Yasunari Nakamoto, Tadanori Hamano, Rei Asano, Yoshinori Endo, Kouji Hayashi, Tomohisa Yamaguchi, Soichi Enomoto, Osamu Yamamura, Asako Ueno, Masamichi Ikawa, Gaoping Lin
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12063, p 12063 (2021)
Volume 22
Issue 21
The neuropathological hallmarks of Alzheimer’s disease (AD) are senile plaques (SPs), which are composed of amyloid β protein (Aβ), and neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau protein. As bio-metal imbalance may
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845a461809aadbe2334a86979657b049
https://pubmed.ncbi.nlm.nih.gov/34769495
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