Výsledky vyhledávání - "Hirohito, Yamaguchi"

Akademický článek

Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors

Autor: Yu-Yi Chu, Clinton Yam, Hirohito Yamaguchi, Mien-Chie Hung

Publikováno v: Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-13 (2022)

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. PARPi exert antitumor activity by

Externí odkaz: https://doaj.org/article/7ed491a03c004081b5f1c5562895ec22

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Akademický článek

Herbal Compounds Dauricine and Isoliensinine Impede SARS-CoV-2 Viral Entry

Autor: Shaneek Natoya Dabrell, Yi-Chuan Li, Hirohito Yamaguchi, Hsiao-Fan Chen, Mien-Chie Hung

Publikováno v: Biomedicines, Vol 11, Iss 11, p 2914 (2023)

Targeting viral entry has been the focal point for the last 3 years due to the continued threat posed by SARS-CoV-2. SARS-CoV-2’s entry is highly dependent on the interaction between the virus’s Spike protein and host receptors. The virus’s Spi

Externí odkaz: https://doaj.org/article/6341bbcebb96474fa40892285dce9eb7

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Akademický článek

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tum

Externí odkaz: https://doaj.org/article/951d591c8f644e74b61e110feda5e096

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Akademický článek

Prospects of the potential strategies to improve the efficacy of anti‐PD‐1/PD‐L1 therapy

Autor: Hirohito Yamaguchi, Shao‐Chun Wang, Mien‐Chie Hung

Publikováno v: Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)

Externí odkaz: https://doaj.org/article/2ac37142e6ff4eee8addba7b380d4eac

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Akademický článek

CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.

Externí odkaz: https://doaj.org/article/db070b7abc844972aa2cc8c48facb949

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Akademický článek

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

Autor: Hirohito Yamaguchi, Ghina M. Taouk

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) are the downstream effectors of the Hippo signaling pathway that play a crucial role in various aspects of cancer progression including metastasis. Metastasis

Externí odkaz: https://doaj.org/article/7f09bba5de1f436393d439896056327d

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