Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hirohisa Miyashita"'
Autor:
Hirohisa Miyashita, Daisuke Oikawa, Seigo Terawaki, Daijiro Kabata, Ayumi Shintani, Fuminori Tokunaga
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Nuclear dot protein 52 kDa (NDP52, also known as CALCOCO2) functions as a selective autophagy receptor. The linear ubiquitin chain assembly complex (LUBAC) specifically generates the N-terminal Met1-linked linear ubiquitin chain, and regulates innate
Externí odkaz:
https://doaj.org/article/537e51a123394a62909b3d4130c365a7
Autor:
Hikaru Ueno, Ryo Ito, Shin-Ichi Abe, Hitomi Ogino, Minoru Maruyama, Hirohisa Miyashita, Yasufumi Miyamoto, Yusuke Moritoh, Yoshiyuki Tsujihata, Koji Takeuchi, Nobuhiro Nishigaki
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222653 (2019)
GPR40/FFAR1 is a Gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, and mediates insulin and incretin secretion to regulate feeding behavior. Several GPR40 full agonists have been reported to reduce food intake in
Externí odkaz:
https://doaj.org/article/8b8c641e5d7b42ad9c100d8692af4d44
Autor:
Fuminori Tokunaga, Ayumi Shintani, Daijiro Kabata, Hirohisa Miyashita, Daisuke Oikawa, Seigo Terawaki
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Nuclear dot protein 52 kDa (NDP52, also known as CALCOCO2) functions as a selective autophagy receptor. The linear ubiquitin chain assembly complex (LUBAC) specifically generates the N-terminal Met1-linked linear ubiquitin chain, and regulates innate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1757ce3e853caa5adcb2baca5dc501
https://pubmed.ncbi.nlm.nih.gov/33815386
https://pubmed.ncbi.nlm.nih.gov/33815386
Autor:
Yoshiyuki Tsujihata, Hirohisa Miyashita, Kae Matsuda, Masahiro Kamaura, Shin-ichi Abe, Kenjiro Sato, Tomoyuki Odani, Osamu Kubo, Hiromichi Sugimoto, Toshiki Murata, Shinji Iwasaki, Naoyoshi Noguchi
Publikováno v:
Bioorganicmedicinal chemistry. 34
We previously identified a novel series of indolinylpyrimidine derivatives exemplified by 2 in Figure 1, which is an indoline based derivative, as potent GPR119 agonists. Despite the attractive potency of 2, this compound inhibited the human ether-a-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166ee25c74829d63bf2f8da183f611d5
https://pubmed.ncbi.nlm.nih.gov/33548803
https://pubmed.ncbi.nlm.nih.gov/33548803
Autor:
Tomoyuki Kitazaki, Kae Matsuda, Hirohisa Miyashita, Shinji Iwasaki, Kenjiro Sato, Shin-ichi Abe, Masahiro Kamaura, Koji Watanabe, Toshiki Murata, Kazuaki Takami, Osamu Kubo, Tomoyuki Odani, Yoshiyuki Tsujihata
Publikováno v:
Bioorganic & Medicinal Chemistry. 41:116208
We undertook an optimization effort involving propan-2-yl 4-({6-[5-(methanesulfonyl)-2,3-dihydro-1H-indol-1-yl]pyrimidin-4-yl}oxy)piperidine-1-carboxylate 1, which we had previously discovered as a novel G protein-coupled receptor 119 (GPR119) agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06da7da98d8f5f5b1b8d577e5040d395
https://doi.org/10.1016/j.bmc.2021.116208
https://doi.org/10.1016/j.bmc.2021.116208
Autor:
Mitsugi Ookawara, Koji Takeuchi, Yusuke Moritoh, Hitomi Ogino, Tomoki Yoshihara, Masanori Watanabe, Shin-ichi Abe, Yoshimasa Ishimura, Ryo Ito, Yoshiyuki Tsujihata, Hirohisa Miyashita, Yasufumi Miyamoto, Nobuhiro Nishigaki, Hikaru Ueno, Yukio Yamada
Publikováno v:
Diabetes. 68
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic islets and enteroendocrine cells. SCO-267 is a novel full agonist of GPR40 being developed as a treatment for type 2 diabetes and obesity. The efficacy of SCO-267 was investigated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3a0ddf0e2ccf75d7e5c23f8f17106d5
https://doi.org/10.2337/db19-1161-p
https://doi.org/10.2337/db19-1161-p
Autor:
Nobuhiro Nishigaki, Hikaru Ueno, Yasufumi Miyamoto, Hirohisa Miyashita, Koji Takeuchi, Yoshiyuki Tsujihata, Minoru Maruyama, Ryo Ito, Hitomi Ogino, Yusuke Moritoh, Shin-ichi Abe
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222653 (2019)
PLoS ONE
PLoS ONE
GPR40/FFAR1 is a Gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, and mediates insulin and incretin secretion to regulate feeding behavior. Several GPR40 full agonists have been reported to reduce food intake in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b1559f6b892d0f098b191edc5c3ebb
https://doaj.org/article/8b8c641e5d7b42ad9c100d8692af4d44
https://doaj.org/article/8b8c641e5d7b42ad9c100d8692af4d44
Autor:
Hitomi Ogino, Tsuyoshi Maekawa, Masanori Watanabe, Mitsugi Ookawara, Koji Takeuchi, Yusuke Moritoh, Hirohisa Miyashita, Hikaru Ueno, Akihiro Kobayashi, Shin-ichi Abe, Nobuhiro Nishigaki, Tomoki Yoshihara, Yukio Yamada, Yoshiyuki Tsujihata, Ryo Ito, Yasufumi Miyamoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 370(2)
The GPR40/FFA1 receptor is a G-protein-coupled receptor expressed in the pancreatic islets and enteroendocrine cells. Here, we report the pharmacological profiles of (3S)-3-cyclopropyl-3-{2-[(1-{2-[(2,2-dimethylpropyl)(6-methylpyridin-2-yl)carbamoyl]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4a5f331c04bf7681bd2215f2d76c46
https://pubmed.ncbi.nlm.nih.gov/31182471
https://pubmed.ncbi.nlm.nih.gov/31182471
Autor:
Kentaro Rikimaru, Kenjiro Sato, Hirohisa Miyashita, Toshiki Murata, Tomoyuki Odani, Yoshiyuki Tsujihata, Hiroshi Imoto, Hiromichi Sugimoto, Nobuyuki Negoro, Masahiro Kamaura
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1649-1666
GPR119 has emerged as an attractive target for anti-diabetic agents. We identified a structurally novel GPR119 agonist 22c that carries a 5-(methylsulfonyl)indoline motif as an early lead compound. To generate more potent compounds of this series, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2562b7ee232d9914f1ede62296113b39
https://doi.org/10.1016/j.bmc.2014.01.028
https://doi.org/10.1016/j.bmc.2014.01.028
Autor:
Yuichiro Amano, Osamu Isono, Hirohisa Miyashita, Hiroshi Nagabukuro, Mayumi Imai, Kimio Tohyama, Hikaru Ueno, Kazumasa Miyawaki, Guido Hanauer, Fumi Shimizu, Nobuhiro Nishigaki, Shuntarou Tsuchiya, Akira Tanaka, Mitsuharu Matsumoto
Publikováno v:
Journal of Hepatology. 70:e796
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f303e6ff0e2d44d79e215c0a0fadaa2
https://doi.org/10.1016/s0618-8278(19)31586-5
https://doi.org/10.1016/s0618-8278(19)31586-5