Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Hirohiko, Hikichi"'
Autor:
Yoshihiro Konno, Shunsuke Kamigaso, Hidetoh Toki, Shuichi Terasaka, Hirohiko Hikichi, Hiromi Endo, Jun‐Ichi Yamaguchi, Akiko Mizuno‐Yasuhira
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract We investigated the metabolism and disposition of vornorexant, a novel dual orexin receptor antagonist, in rats and dogs, and clarified in vitro metabolite profiles in humans. Furthermore, we investigated the pharmacokinetics of active metab
Externí odkaz:
https://doaj.org/article/f0fdc42495644a57a4587a112985bc33
Autor:
Hirohiko Hikichi, Tetsuaki Hiyoshi, Toshiyuki Marumo, Yasumitsu Tomishima, Ayaka Kaku, Izumi Iida, Hiroki Urabe, Tomoko Tamita, Akito Yasuhara, Jun-ichi Karasawa, Shigeyuki Chaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 352-361 (2015)
Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal models of schizophrenia. In this study, we
Externí odkaz:
https://doaj.org/article/b56722cac0fc4fd59c23db537c537189
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 1, Pp 10-16 (2013)
Abstract.: Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. Both the stimulation of the metabotropic glutamate (mGlu) 2/3 receptor and the blockade of the mGlu1 receptor have been shown to be effective in
Externí odkaz:
https://doaj.org/article/64f65c83271e477c8d44d5feecae42fb
Autor:
Ayaka Kaku-Fukumoto, Noriko Hino, Hirohiko Hikichi, Dai Nozawa, Jun-ichi Karasawa, Toshio Nakamura, Emi Tatsuda, Shigeyuki Chaki, Yasumitsu Tomishima, Toshiyuki Marumo, Toshiharu Shimazaki, Makiko Kotani, Hiroko Komiyama
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 375:276-285
Histamine H3 receptor antagonists/inverse agonists are known to enhance the activity of histaminergic neurons in the brain, thereby promoting arousal and cognition. Here, we report the in vitro and in vivo pharmacological profiles for a newly synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf1b46a58c5f29e719fa092f8a420ec
https://doi.org/10.1124/jpet.120.000185
https://doi.org/10.1124/jpet.120.000185
Autor:
Kohnosuke Kinoshita, Misako Fukasawa, Shigeru Okuyama, Brian Marcy, Shigeru Yoshida, Hakop Gevorkyan, Hirohiko Hikichi, Shigeyuki Chaki, Mai Watanabe
Publikováno v:
British Journal of Clinical Pharmacology
Aims The safety and pharmacokinetics of single and multiple doses of a novel mGlu2/3 receptor agonist prodrug, MGS0274 besylate (TS-134), were investigated in healthy subjects. Methods Phase 1 single-ascending dose (5-20 mg) and multiple-ascending do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4710244ebf18b7ec5bb0dd9b7ab86279
https://doi.org/10.1111/bcp.14331
https://doi.org/10.1111/bcp.14331
Autor:
Gentaroh Suzuki, Hiroko Kawagoe-Takaki, Takao Inoue, Toshifumi Kimura, Hirohiko Hikichi, Takashi Murai, Akio Satow, Mikiko Hata, Shunsuke Maehara, Satoru Ito, Hiroshi Kawamoto, Satoshi Ozaki, Hisashi Ohta
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 3, Pp 315-325 (2009)
Abstract.: The aim of this study was to clarify the relationship between receptor occupancy and In vivo pharmacological activity of mGluR1 antagonists. The tritiated mGluR1-selective allosteric antagonist [3H]FTIDC (4-[1-(2-fluoropyridin-3-yl)-5-meth
Externí odkaz:
https://doaj.org/article/6bf604453a04428db2000bdf467daf44
Autor:
Noriko, Hino, Toshiyuki, Marumo, Makiko, Kotani, Toshiharu, Shimazaki, Ayaka, Kaku-Fukumoto, Hirohiko, Hikichi, Jun-Ichi, Karasawa, Yasumitsu, Tomishima, Hiroko, Komiyama, Emi, Tatsuda, Dai, Nozawa, Toshio, Nakamura, Shigeyuki, Chaki
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(2)
Histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4bb83aca81af8a17a5879f4ee7f1340
https://pubmed.ncbi.nlm.nih.gov/32862143
https://pubmed.ncbi.nlm.nih.gov/32862143
Autor:
Naoki Miyakoshi, Motoki Ochi, Toshiyuki Marumo, Misako Fukasawa, Takashi Hashihayata, Hiroki Urabe, Akiko Nozoe, Junichi Yamaguchi, Kohnosuke Kinoshita, Shigeyuki Chaki, Norikazu Ohtake, Hirohiko Hikichi
Publikováno v:
European journal of medicinal chemistry. 203
We previously reported that MGS0008 is a selective group II metabotropic glutamate receptor (mGlu2/3 receptor) agonist that is effective in animal models of schizophrenia. MGS0008 is a highly hydrophilic glutamate analog and is therefore expected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd7fdcf1e674d170275b8838d244759
https://pubmed.ncbi.nlm.nih.gov/32698110
https://pubmed.ncbi.nlm.nih.gov/32698110
0004 TS-142: A Novel and Potent Dual Orexin Receptor Antagonist with Sleep-Promoting Effects in Rats
Publikováno v:
Sleep. 43:A2-A2
Introduction The orexin system plays a pivotal role in regulating sleep and wakefulness, thus, orexin receptors (OX1 and OX2 receptors) have gained much attention as promising therapeutic targets for the treatment of insomnia. We synthesized a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::776824c6e1745ef2ad0d67c182ef5bee
https://doi.org/10.1093/sleep/zsaa056.003
https://doi.org/10.1093/sleep/zsaa056.003
Autor:
Hiroyuki Koike, Daiji Kambe, Jun-ichi Karasawa, Hirohiko Hikichi, Kohnosuke Kinoshita, Ayaka Kaku, Shigeyuki Chaki, Kazuaki Kawaura
Publikováno v:
Behavioural Brain Research. 278:186-192
Glutamatergic dysfunction, particularly the hypofunction of N-methyl-D-aspartate (NMDA) receptors, is involved in the pathophysiology of schizophrenia. The positive modulation of the glycine site on the NMDA receptor has been proposed as a novel ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f151be3c0d0495da9517aa12771517
https://doi.org/10.1016/j.bbr.2014.09.046
https://doi.org/10.1016/j.bbr.2014.09.046