Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hiroharu Matsuoka"'
Autor:
Masami Kohchi, Masayuki Matsushita, Nukinori Akiyama, Nobuya Ishii, Naoki Taka, Takehito Isobe, Kyoko Takami, Masayuki Ohmori, Tadakatsu Hayase, Hirosato Ebiike, Hiroharu Matsuoka, Hiroki Nishii, Hidetoshi Shindoh, Kenji Morikami, Ikumi Hyohdoh, Yoshito Nakanishi
Publikováno v:
Journal of medicinal chemistry. 59(23)
The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases regulates multiple biological processes, such as cell proliferation, migration, apoptosis, and differentiation. Various genetic alterations that drive activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cbac7cc9444a57fe0b292390549b8f
https://pubmed.ncbi.nlm.nih.gov/27933954
https://pubmed.ncbi.nlm.nih.gov/27933954
Autor:
Tsutomu Sato, Naoki Taka, Masahiro Nishimoto, Takamitsu Kobayashi, Hitoshi Hagita, Motohiro Kato, Kazumi Morikawa, Keisuke Yamamoto, Koji Yamaguchi, Masatoshi Murakata, Masayuki Suzuki, Masayuki Ohmori, Sachiya Ikeda, Nobuo Shimma, Hiroharu Matsuoka, Yoshihito Ohtake, Kazuharu Ozawa, Koji Takano, Takashi Higuchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5334-5341
5a-Carba-β-D-glucopyranose derivatives were synthesized and identified as novel SGLT2-selective inhibitors. These inhibitors exhibited potent SGLT2 inhibition with high selectivity over SGLT1. Among the tested compounds, 6f indicated the most potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea0d9dbccb737ece42c208ed94808f9
https://doi.org/10.1016/j.bmc.2011.08.005
https://doi.org/10.1016/j.bmc.2011.08.005
Autor:
Yukio Kato, Yuichi Sugiyama, Yong–Hae Han, Hiroharu Matsuoka, Masateru Ohta, Masayuki Haramura
Publikováno v:
Pharmaceutical Research. 18:579-586
Purpose. Canalicular multispecific organic anion transporter (cMOAT/MRP2) is known to exhibit a broad substrate specificity toward amphiphatic organic anions, including methotrexate (MTX). The present study aims to identify the physicochemical proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df15ea79e983a50422897c510a568dc4
https://doi.org/10.1023/a:1011064806507
https://doi.org/10.1023/a:1011064806507
Autor:
Noriaki Maruyama, Keiichi Yano, Hiroshi Suzuki, Nobuaki Kato, Hiroharu Matsuoka, Keiichiro Tsuji, Masahiko Mihara, Yasuhisa Takeda
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:1332-1337
Various novel methotrexate (MTX) derivatives bearing an indoline moiety were synthesized and tested for biological activities using human peripheral blood mononuclear cell (hPBMC) and human synovial cells (hSC) derived from patients with rheumatoid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f019a73775e0a0d212fb2804b8c8d087
https://doi.org/10.1248/cpb.44.1332
https://doi.org/10.1248/cpb.44.1332
Autor:
Motohiro Kato, Masayuki Suzuki, Naoki Taka, Masayuki Ohmori, Hiroharu Matsuoka, Keisuke Yamamoto, Koo-Hyeon Ahn, Kazumi Morikawa, Sang-Yong Yeu, Marina Yamaguchi, Hitoshi Hagita, Sachiya Ikeda, Koji Takano, Koji Yamaguchi, Tsutomu Sato, Takamitsu Kobayashi, Kazuharu Ozawa, Masahiro Nishimoto, Kyoko Takami, Yoshihito Ohtake
Publikováno v:
Journal of medicinal chemistry. 55(17)
Inhibition of sodium glucose cotransporter 2 (SGLT2) has been proposed as a novel therapeutic approach to treat type 2 diabetes. In our efforts to discover novel inhibitors of SGLT2, we first generated a 3D pharmacophore model based on the superposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6fd1743cdadf86034d4628892b3d23
https://pubmed.ncbi.nlm.nih.gov/22889351
https://pubmed.ncbi.nlm.nih.gov/22889351
Autor:
Nobuo Shimma, Hiroharu Matsuoka, Motohiro Kato, Keisuke Yamamoto, Masahiro Nishimoto, Tsutomu Sato, Masayuki Ohmori, Takashi Higuchi, Naoki Taka, Sachiya Ikeda, Hitoshi Hagita, Masayuki Suzuki, Kazuharu Ozawa, Yoshihito Ohtake, Koji Yamaguchi, Masatoshi Murakata, Takamitsu Kobayashi, Kazumi Morikawa, Koji Takano
Publikováno v:
Bioorganicmedicinal chemistry. 20(13)
C-Aryl 5a-carba-β-d-glucopyranose derivatives were synthesized and evaluated for inhibition activity against hSGLT1 and hSGLT2. Modifications to the substituents on the two benzene rings resulted in enhanced hSGLT2 inhibition activity and extremely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1ea947d5a08f6ef04a2f3580142bbc
https://pubmed.ncbi.nlm.nih.gov/22652255
https://pubmed.ncbi.nlm.nih.gov/22652255
Autor:
Ikuhiro Imaoka, Tsutomu Sato, Haruhiko Sato, Toshio Kuroki, Yoshikazu Kumagai, Hiroharu Matsuoka, Kenshi Kamei, Ken-ichi Ozaki, Naoki Taka, Ken-ichiro Kotake, Hitoshi Yoshino, Atsuko Higashida
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(13)
We successfully discovered peptidomimetic motilin antagonists (17c and 17d) through the improvement of physicochemical properties of a tetrapeptide antagonist (2). Furthermore, with oral administration and based on motilin antagonistic activity, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004f76a02c55fc6d71b6ccbc98de77d7
https://pubmed.ncbi.nlm.nih.gov/19481451
https://pubmed.ncbi.nlm.nih.gov/19481451
Autor:
Hirosato Ebiike, Naoki Taka, Masayuki Matsushita, Masayuki Ohmori, Kyoko Takami, Ikumi Hyohdoh, Masami Kohchi, Tadakatsu Hayase, Hiroki Nishii, Kenji Morikami, Yoshito Nakanishi, Nukinori Akiyama, Hidetoshi Shindoh, Nobuya Ishii, Takehito Isobe, Hiroharu Matsuoka
Publikováno v:
Journal of Medicinal Chemistry; Dec2016, Vol. 59 Issue 23, p10586-10600, 15p
Autor:
Masayuki Ohmori, Naoki Taka, Kyouko Takami, Nobuya Ishii, Masayuki Matsushita, Nukinori Akiyama, Hiroki Nishii, Hirosato Ebiike, Hiroharu Matsuoka, Tadakatsu Hayase, Masami Kohchi, Kenji Morikami, Yoshito Nakanishi, Fumie Sawamura, Ikumi Hyohdoh
Publikováno v:
Cancer Research. 74:2533-2533
The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases (RTKs) comprises four members (FGFR1-4). FGFRs regulate multiple biological processes, such as cell proliferation, migration, apoptosis, and differentiation. Various gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd0626c2010eb036eccb210dc12537b2
https://doi.org/10.1158/1538-7445.am2014-2533
https://doi.org/10.1158/1538-7445.am2014-2533
Autor:
Yasuhisa Takeda, Nobuhiro Ohi, Nobuaki Kato, Katsuhito Miyamoto, Hiroharu Matsuoka, Masahiko Mihara
Publikováno v:
Chemicalpharmaceutical bulletin. 45(7)
The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nb-(3-carboxyphenyl)-N alpha-[1-[(2,4-diaminopteridin-6-yl)-methyl] indoline-5-ylca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edbddea0c3814331fc33ee535588c01
https://pubmed.ncbi.nlm.nih.gov/9246747
https://pubmed.ncbi.nlm.nih.gov/9246747