Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hirofumi Toyama"'
Autor:
Masafumi Sawada, Yutaka Shiraishi, Hirofumi Toyama, Tomoki Tanaka, Ryuichi Kota, Naoyuki Shigematsu
Publikováno v:
Journal of Contemporary Brachytherapy, Vol 15, Iss 4, Pp 269-274 (2023)
Externí odkaz:
https://doaj.org/article/debfb17d15b1497eb0354acf3d28ea10
Autor:
Kentaro Hosokawa, Ben D. MacArthur, Yoshiko Matsumoto Ikushima, Hirofumi Toyama, Yoshikazu Masuhiro, Shigemasa Hanazawa, Toshio Suda, Fumio Arai
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species
Externí odkaz:
https://doaj.org/article/103e2c9006e24accbe1d6a3f00d0aa0c
Autor:
Mitsuyoshi Ichihashi, Hirofumi Toyama, Yukito Saitoh, Satoshi Kuniyasu, Takahiro Hayashi, Yoji Ito
Publikováno v:
SID Symposium Digest of Technical Papers. 52:690-693
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a7059816063f30d3fe794b54d65f568
https://doi.org/10.1002/sdtp.14777
https://doi.org/10.1002/sdtp.14777
Autor:
Keizo Nishikawa, Akiyoshi Hirayama, Masaru Ishii, Terumasa Umemoto, Miho Kataoka, Hisashi Hasumi, Chiharu Esumi, Naomi Nakagata, Tomoyoshi Soga, Toshio Suda, Nobuko Irie, Hiroyuki Hano, Keiyo Takubo, Tomomi Kamba, Takashi Minami, Masaya Baba, Michihiro Hashimoto, Masahiro Yao, Wenjuan Ma, Mitsuhiro Endoh, Hirofumi Toyama
Publikováno v:
Journal of Bone and Mineral Research. 33:1785-1798
Osteoclast differentiation is a dynamic differentiation process, which is accompanied by dramatic changes in metabolic status as well as in gene expression. Recent findings have revealed an essential connection between metabolic reprogramming and dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91bd34efdf08d7be46a246b82bfc189a
https://doi.org/10.1002/jbmr.3477
https://doi.org/10.1002/jbmr.3477
Autor:
Natsuru Chikushi, Shinji Hikita, Takashi Yonemoto, Yoichi Suga, Hirofumi Toyama, Yoji Ito, Hideyuki Nishikawa, Tatsuya Oba, Akiko Watano
Publikováno v:
SID Symposium Digest of Technical Papers. 49:518-521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e943c64d61903f56ff143a8867da110
https://doi.org/10.1002/sdtp.12449
https://doi.org/10.1002/sdtp.12449
Autor:
Toshio Suda, Kentaro Hosokawa, Fumio Arai, Yoshikazu Masuhiro, Ben D. MacArthur, Shigemasa Hanazawa, Yoshiko Matsumoto Ikushima, Hirofumi Toyama
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cec92bb4c2eaa25e89c2feb70e0d67
https://eprints.soton.ac.uk/413651/
https://eprints.soton.ac.uk/413651/
Autor:
Kentaro, Hosokawa, Ben D, Macarthur, Yoshiko, Ikushima, Hirofumi, Toyama, Yoshikazu, Masuhiro, Shigemasa, Hanazawa, Toshio, Suda, Fumio, Arai
Publikováno v:
[Rinsho ketsueki] The Japanese journal of clinical hematology. 58(8)
Repeated cell divisions induce DNA damage accumulation, which impairs stem cell function during aging. However, the general molecular mechanisms by which this occurs remain unclear. Herein, we show that the expression of protection of telomeres 1a (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86e19884befa14067035836bbd52e6f6
https://pubmed.ncbi.nlm.nih.gov/28883279
https://pubmed.ncbi.nlm.nih.gov/28883279
Autor:
Kentaro Hosokawa, Fumio Arai, Hirofumi Toyama, Shuh Narumiya, Keiyo Takubo, Tomoyuki Furuyashiki, Yoshiko Matsumoto Ikushima, Toshio Suda
Publikováno v:
Blood. 121:1995-2007
Prostaglandin E(2) (PGE(2)) regulates hematopoietic stem/progenitor cell (HSPC) activity. However, the receptor(s) responsible for PGE(2) signaling remains unclear. Here, we identified EP4 as a receptor activated by PGE(2) to regulate HSPCs. Knockdow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcad91ac7fa5e87b3aa610ccdced3123
https://doi.org/10.1182/blood-2012-06-437889
https://doi.org/10.1182/blood-2012-06-437889
Publikováno v:
Biochemical and Biophysical Research Communications. 428:354-359
Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment known as the stem cell niche. The regulation of HSCs in fetal liver (FL) and their niche, however, remains to be elucidated. In this study, we investigated the role of N-cadhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b314a3bda8c10db9c4d94ca34dd04f14
https://doi.org/10.1016/j.bbrc.2012.10.058
https://doi.org/10.1016/j.bbrc.2012.10.058
Publikováno v:
Annals of the New York Academy of Sciences. 1266:72-77
Cell-cell and cell-extracellular matrix interactions between hematopoietic stem cells (HSCs) and their niches are critical for the maintenance of stem cell properties. Here, it is demonstrated that a cell adhesion molecule, N-cadherin, is expressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b3f364784f823fa78fd699a75111000
https://doi.org/10.1111/j.1749-6632.2012.06576.x
https://doi.org/10.1111/j.1749-6632.2012.06576.x