Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Hirofumi Shibata"'
Autor:
Takahiro Hatta, Tetsunari Hase, Toru Hara, Tomoki Kimura, Eiji Kojima, Takashi Abe, Yoshitsugu Horio, Yasuhiro Goto, Naoya Ozawa, Naoyuki Yogo, Hirofumi Shibata, Tomoya Shimokata, Tetsuya Oguri, Masashi Yamamoto, Kiyoshi Yanagisawa, Masahiko Ando, Yuichi Ando, Masashi Kondo, Makoto Ishii, Yoshinori Hasegawa
Publikováno v:
Cancer Medicine, Vol 12, Iss 15, Pp 15955-15969 (2023)
Abstract Background The Cockcroft–Gault formula is commonly used as a substitute for glomerular filtration rate (GFR) in Calvert's formula for carboplatin dosing, where adjusting serum creatinine measured using the enzymatic method with 0.2 mg/dL h
Externí odkaz:
https://doaj.org/article/a40d3403fb414a989bb00b6f8030a3d5
Autor:
Hiromasa Tanaka, Daijiro Iwata, Yuki Shibata, Tetsunari Hase, Daisuke Onoshima, Naoyuki Yogo, Hirofumi Shibata, Mitsuo Sato, Kenji Ishikawa, Ikuo Nagasawa, Yoshinori Hasegawa, Makoto Ishii, Yoshinobu Baba, Masaru Hori
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Various liquid biopsy methods have been developed for the non-invasive and early detection of diseases. In particular, the detection of circulating tumor cells (CTCs) and cancer-associated fibroblasts (CAFs) in blood has been receiving a gre
Externí odkaz:
https://doaj.org/article/691b5df5199a459b98fac9e5ddf5e7bd
Autor:
Bonnie Huang, James D. Phelan, Silvia Preite, Julio Gomez-Rodriguez, Kristoffer H. Johansen, Hirofumi Shibata, Arthur L. Shaffer, Qin Xu, Brendan Jeffrey, Martha Kirby, Stacie Anderson, Yandan Yang, Selamawit Gossa, Dorian B. McGavern, Louis M. Staudt, Pamela L. Schwartzberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
T follicular helper (Tfh) and T help type 1 (Th1) cells both arise from naïve CD4 T cells, but detailed knowledge of their differentiation remains incomplete. Here the authors pursue an in vivo CRISPR screen to identify genes, focusing on druggable
Externí odkaz:
https://doaj.org/article/f2c40bd54ddf4ca49421a503fe6ad4d6
Autor:
Jumpei Taguchi, Hirofumi Shibata, Mio Kabata, Masaki Kato, Kei Fukuda, Akito Tanaka, Sho Ohta, Tomoyo Ukai, Kanae Mitsunaga, Yosuke Yamada, So I Nagaoka, Sho Yamazawa, Kotaro Ohnishi, Knut Woltjen, Tetsuo Ushiku, Manabu Ozawa, Mitinori Saitou, Yoichi Shinkai, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and d
Externí odkaz:
https://doaj.org/article/ce67fa07507345ab98bca02b31126aed
Autor:
Nao Sankoda, Wataru Tanabe, Akito Tanaka, Hirofumi Shibata, Knut Woltjen, Tsutomu Chiba, Hironori Haga, Yoshiharu Sakai, Masaki Mandai, Takuya Yamamoto, Yasuhiro Yamada, Shinji Uemoto, Yoshiya Kawaguchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–co
Externí odkaz:
https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f035
Autor:
Fumiya Wada, Tadakazu Kondo, Momoko Nakamura, Shunsuke Uno, Masakazu Fujimoto, Takayuki Miyamoto, Yoshitaka Honda, Hirofumi Shibata, Kazushi Izawa, Takahiro Yasumi, Momoko Nishikori, Akifumi Takaori‐Kondo
Publikováno v:
eJHaem, Vol 1, Iss 2, Pp 581-584 (2020)
Externí odkaz:
https://doaj.org/article/9bb532aec1ac4c4893afc8049208f7a8
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Neoadjuvant immunotherapy has the potential to enhance clinical outcomes by increasing anti-tumor immune responses in the presence of abundant tumor-derived antigen in an immune microenvironment that has not been exposed to previous therapy. The curr
Externí odkaz:
https://doaj.org/article/2eacbc1846304f78864b894a58eb30e7
Autor:
Shingo Komura, Kenji Ito, Sho Ohta, Tomoyo Ukai, Mio Kabata, Fumiaki Itakura, Katsunori Semi, Yutaka Matsuda, Kyoichi Hashimoto, Hirofumi Shibata, Masamitsu Sone, Norihide Jo, Kazuya Sekiguchi, Takatoshi Ohno, Haruhiko Akiyama, Katsuji Shimizu, Knut Woltjen, Manabu Ozawa, Junya Toguchida, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerve
Externí odkaz:
https://doaj.org/article/d6a0a59accc9488fa4d118ffc7d1f1f9
Autor:
Daisuke Yoshinaga, Shiro Baba, Takeru Makiyama, Hirofumi Shibata, Takuya Hirata, Kentaro Akagi, Koichi Matsuda, Hirohiko Kohjitani, Yimin Wuriyanghai, Katsutsugu Umeda, Yuta Yamamoto, Bruce R. Conklin, Minoru Horie, Junko Takita, Toshio Heike
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 394-404 (2019)
Summary: For long QT syndrome (LQTS), recent progress in genome-sequencing technologies enabled the identification of rare genomic variants with diagnostic, prognostic, and therapeutic implications. However, pathogenic stratification of the identifie
Externí odkaz:
https://doaj.org/article/b189b2413cc34770b097f88d43dcd361
Autor:
Sho Masui, Atsushi Yonezawa, Kazushi Izawa, Makoto Hayakari, Kayoko Asakura, Risa Taniguchi, Masahiko Isa, Hirofumi Shibata, Takahiro Yasumi, Ryuta Nishikomori, Junko Takita, Kazuo Matsubara
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 5, Iss 1, Pp 1-4 (2019)
Abstract Background Infliximab (IFX), a mouse-human chimeric monoclonal antibody against human tumor necrosis factor alpha, is used in refractory cases of Takayasu arteritis. Several factors influence the pharmacokinetics of therapeutic antibodies in
Externí odkaz:
https://doaj.org/article/f66bc25d762f426fb92c4496d8179f74