Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hirofumi Nohara"'
Autor:
Ryunosuke Nakashima, Hirofumi Nohara, Noriki Takahashi, Aoi Nasu, Megumi Hayashi, Tomoki Kishimoto, Shunsuke Kamei, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 37-45 (2022)
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic t
Externí odkaz:
https://doaj.org/article/a3fdda52c3ac4d2197ce82bec8cd299c
Autor:
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis. However, the ability of metformin to improve n
Externí odkaz:
https://doaj.org/article/d6c03b25c7634eeda9e0874c08df981e
Autor:
Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico, Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 113-119 (2019)
Pulmonary emphysema, inflammation and senescence-like phenotype are pathophysiological characteristics of chronic obstructive pulmonary disease (COPD). Recently, a murine model of COPD has been established by inducing airway-specific overexpression o
Externí odkaz:
https://doaj.org/article/9dba2af5bc884f9f9a2c4e0d58be15c4
Autor:
Shunsuke Kamei, Haruka Fujikawa, Hirofumi Nohara, Keiko Ueno-Shuto, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Chizuru Matsumoto, Yuki Sakaguchi, Tomomi Ono, Mary Ann Suico, Richard C. Boucher, Dieter C. Gruenert, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 304-316 (2018)
Airway mucus hyperproduction and fluid imbalance are important hallmarks of cystic fibrosis (CF), the most common life-shortening genetic disorder in Caucasians. Dysregulated expression and/or function of airway ion transporters, including cystic fib
Externí odkaz:
https://doaj.org/article/19a6570ae092400f9570190db666d79f
Autor:
Haruka Fujikawa, Yuki Sakamoto, Natsuki Masuda, Kentaro Oniki, Shunsuke Kamei, Hirofumi Nohara, Ryunosuke Nakashima, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Toru Takeo, Naomi Nakagata, Hiroshi Watanabe, Koji Otake, Yasuhiro Ogata, Naoko H. Tomioka, Makoto Hosoyamada, Tappei Takada, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Junji Saruwatari, Tsuyoshi Shuto
Publikováno v:
Antioxidants, Vol 9, Iss 5, p 387 (2020)
The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, p
Externí odkaz:
https://doaj.org/article/a1b150bf3848422eb2fba666b5aeeeac
Autor:
Jian Dong Li, Misato Kamura, Haruka Kojima, Tsuyoshi Shuto, Kohei Omachi, Hirofumi Nohara, Shogo Misumi, Mary Ann Suico, Jun Kuwazuru, Jeffrey H. Miner, Kosuke Koyama, Sumio Ohtsuki, Keisuke Teramoto, Shota Kaseda, Toru Takeo, Tsubasa Yokota, Naomi Nakagata, Hirofumi Kai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis. However, the ability of metformin to improve non-diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b89f186792b71383e279a761741580
https://doaj.org/article/d6c03b25c7634eeda9e0874c08df981e
https://doaj.org/article/d6c03b25c7634eeda9e0874c08df981e
Autor:
Tetsuro Hasegawa, Ikuko Maeda, Hiroko Hirashima, Hirofumi Nohara, Rika Ohno, Rinnosuke Hisazumi, Masahito Nakata, Kenshi Shimizu, Taketo Uchiyama
Publikováno v:
Japanese Journal of Forensic Science and Technology. 26:17-27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec2c25bdf0d3273a1788660cc6f82e0
https://doi.org/10.3408/jafst.778
https://doi.org/10.3408/jafst.778
Autor:
Tsuyoshi Shuto, Hirofumi Nohara, Toru Takeo, Hirofumi Kai, Yuka Eto, Taise Kawakami, Mary Ann Suico, Shunsuke Kamei, Aoi Nasu, Ryunosuke Nakashima, Haruka Fujikawa, Naomi Nakagata, Keiko Ueno-Shuto
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:725-730
Epithelial sodium channel (ENaC) is an amiloride-sensitive sodium ion channel that is expressed in epithelial tissues. ENaC overexpression and/or hyperactivation in airway epithelial cells cause sodium over-absorption and dysregulated ciliary movemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd394a4c75370e657e6af678fdccbb8
https://doi.org/10.1248/bpb.b19-01091
https://doi.org/10.1248/bpb.b19-01091
Autor:
Yasuhiro Ogata, Junji Saruwatari, Yuka Eto, Yuki Sakamoto, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto, Mary Ann Suico, Natsuki Masuda, Tappei Takada, Keiko Ueno-Shuto, Taisei Kawakami, Toru Takeo, Makoto Hosoyamada, Ryunosuke Nakashima, Hirofumi Nohara, Kasumi Maruta, Haruka Fujikawa, Hiroshi Watanabe, Naoko H. Tomioka, Kentaro Oniki, Koji Otake, Shunsuke Kamei, Noriki Takahashi
Publikováno v:
Antioxidants, Vol 9, Iss 387, p 387 (2020)
Antioxidants
Volume 9
Issue 5
Antioxidants
Volume 9
Issue 5
The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6e0928baa8f17fef652c8f4c65591c
https://www.mdpi.com/2076-3921/9/5/387
https://www.mdpi.com/2076-3921/9/5/387
Autor:
Takehisa Watanabe, Keishi Miyata, Haruka Fujikawa, Tadashi Imafuku, Shunsuke Kotani, Yuka Eto, Kentaro Oniki, Yuri Seguchi, Junji Saruwatari, Tsuyoshi Shuto, Hirofumi Kai, Yui Obata, Mary Ann Suico, Azusa Nakashima, Toru Maruyama, Noriki Takahashi, Hirofumi Nohara, Hiroshi Watanabe, Taisei Kawakami, Aoi Nasu, Ryunosuke Nakashima, Yuki Sakamoto
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Melinjo seed extract (MSE) contains large amounts of polyphenols, including dimers of trans-resveratrol (e.g. gnetin C, L, gnemonoside A, B and D), and has been shown to potentially improve obesity. However, there is no clinical evidence regarding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3035320d0f49a763a7c808f64193a0
http://europepmc.org/articles/PMC7062855
http://europepmc.org/articles/PMC7062855