Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Hirofumi Nagao"'
Autor:
Kohei Fujii, Yuya Fujishima, Shunbun Kita, Keitaro Kawada, Keita Fukuoka, Taka-aki Sakaue, Tomonori Okita, Emi Kawada-Horitani, Hirofumi Nagao, Shiro Fukuda, Norikazu Maeda, Hitoshi Nishizawa, Iichiro Shimomura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demons
Externí odkaz:
https://doaj.org/article/46fee8e55cb540909f4d3fdcc2997904
Autor:
Hirofumi Nagao, Hitoshi Nishizawa, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Norikazu Maeda, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura
Publikováno v:
Endocrine Journal, Vol 71, Iss 1, Pp 55-63 (2023)
Visceral fat accumulation is a major determinant of type 2 diabetes mellitus and cardiovascular diseases. Recent studies have reported that glutamate is the most elevated amino acid in the plasma amino acid profile in patients with obesity and/or vis
Externí odkaz:
https://doaj.org/article/670f539035a64943b42be14ab1842a95
Autor:
Jihoon Shin, Shinichiro Toyoda, Yosuke Okuno, Reiko Hayashi, Shigeki Nishitani, Toshiharu Onodera, Haruyo Sakamoto, Shinya Ito, Sachiko Kobayashi, Hirofumi Nagao, Shunbun Kita, Michio Otsuki, Atsunori Fukuhara, Kazuhiro Nagata, Iichiro Shimomura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Adiposity varies among individuals with the influence of diverse physiological, pathological, environmental, hormonal, and genetic factors, but a unified molecular basis remains elusive. Here, we identify HSP47, a collagen-specific chaperone
Externí odkaz:
https://doaj.org/article/0b6269b282184cd7a12a5062591aad30
Autor:
Hirofumi Nagao, Ashok Kumar Jayavelu, Weikang Cai, Hui Pan, Jonathan M. Dreyfuss, Thiago M. Batista, Bruna B. Brandão, Matthias Mann, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Nagao et al. show that the insulin receptor can mediate receptor-dependent, but ligand- and tyrosine kinase-independent, events. These are associated with regulation of extracellular matrix, cell cycle, ATM signaling, senescence and apoptosis.
Externí odkaz:
https://doaj.org/article/67ef010fde4a43c48ec2f88b1f796fbb
Autor:
Hirofumi Nagao, Weikang Cai, Bruna B. Brandão, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, Hui Pan, Jonathan M. Dreyfuss, F. Thomas Wunderlich, Matthias Mann, C. Ronald Kahn
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here
Externí odkaz:
https://doaj.org/article/22ea319743b447ccb3e07487b07381ad
Autor:
Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Hirofumi Nagao, Takashi Nakamura, Seigo Akari, Takayo Murase, Naohiro Taya, Kazuo Omori, Akimitsu Miyake, Shiro Fukuda, Mitsuyoshi Takahara, Shunbun Kita, Naoto Katakami, Norikazu Maeda, Iichiro Shimomura
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1512-1520 (2021)
Abstract Aims/Introduction Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known ab
Externí odkaz:
https://doaj.org/article/f2ce0785a88f4b8199985e0ca0efea42
Autor:
Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Takashi Nakamura, Seigo Akari, Takayo Murase, Takuro Saito, Yasuhiro Miyazaki, Hirofumi Nagao, Shiro Fukuda, Shunbun Kita, Naoto Katakami, Yuichiro Doki, Norikazu Maeda, Iichiro Shimomura
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine to xanthine and xanthine to uric acid, respectively. However, the underlying mechanisms of increased plasma XOR and its pathological roles in systemic diseases, such as atheroscle
Externí odkaz:
https://doaj.org/article/6b445fb29d3c41158f99d3631d5a6e31
Autor:
Jun Murai, Hitoshi Nishizawa, Akihito Otsuka, Shiro Fukuda, Yoshimitsu Tanaka, Hirofumi Nagao, Yasuna Sakai, Masahide Suzuki, Shinji Yokota, Hidetoshi Tada, Mayumi Doi, Yuya Fujishima, Shunbun Kita, Tohru Funahashi, Norikazu Maeda, Tadashi Nakamura, Iichiro Shimomura
Publikováno v:
Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract Background Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia in the elderly have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength, and quality) and car
Externí odkaz:
https://doaj.org/article/db18d9df0446418f9b89701b3ce1c05d
Autor:
Hirofumi Nagao, Hitoshi Nishizawa, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Norikazu Maeda, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura
Publikováno v:
Endocrine Journal; 2024, Vol. 71 Issue 1, p55-63, 9p
Autor:
Hirofumi Nagao, Weikang Cai, Bruna B. Brandão, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, Hui Pan, Jonathan M. Dreyfuss, F. Thomas Wunderlich, Matthias Mann, C. Ronald Kahn
Publikováno v:
Nagao, H, Cai, W, Brandão, B B, Wewer Albrechtsen, N J, Steger, M, Gattu, A K, Pan, H, Dreyfuss, J M, Thomas Wunderlich, F, Mann, M & Ronald Kahn, C 2023, ' Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling ', Journal of Clinical Investigation, vol. 133, no. 4, e161472 . https://doi.org/10.1172/JCI161472
Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here