Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hirofumi Mizusaki"'
Autor:
Haruhiko Koseki, Yoshiaki Kodama, Satoshi Inoue, Takashi Ito, Hirofumi Mizusaki, Masanori Kato, Tomonori Hayashi, Edwin Cheung, Mitsuhiro Yoneda, Yukio Takeshima, Takeya Nakagawa, Hitoshi Aihara, Tsuyoshi Ikura, Masaya Oki, Ken-ichi Takayama, Yuko Imamura, Masamichi Doiguchi, Miki Higashi, Toshiyuki Nakayama, Hiroyuki Aburatani
Publikováno v:
Molecular Cell. 64:176-188
How deregulation of chromatin modifiers causes malignancies is of general interest. Here, we show that histone H2A T120 is phosphorylated in human cancer cell lines and demonstrate that this phosphorylation is catalyzed by hVRK1. Cyclin D1 was one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d69270e30c7be52d99641c3bc755ca3
https://doi.org/10.1016/j.molcel.2016.09.012
https://doi.org/10.1016/j.molcel.2016.09.012
Autor:
Hirofumi Mizusaki, Yoshiakira Kanai, Dagmar Wilhelm, Ryuji Hiramatsu, Laura Widjaja, Alexander N. Combes, Peter Koopman
Publikováno v:
Journal of Biological Chemistry. 282:10553-10560
In mammals, male sex is determined by the Y-chromosomal gene Sry (sex-determining region of Y chromosome). The expression of Sry and subsequently Sox9 (SRY box containing gene 9) in precursors of the supporting cell lineage results in the differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedb8a9f732aa28adefcb2237c5380af
https://doi.org/10.1074/jbc.m609578200
https://doi.org/10.1074/jbc.m609578200
Autor:
Yuko Imamura, Masamichi Doiguchi, Miki Higashi, Satoshi Fujii, Takeya Nakagawa, Daishi Inoue, Tatsuharu Sato, Akihiko Okuda, Takashi Ito, Mitsuhiro Yoneda, Hirofumi Mizusaki, Takayuki Miyanishi, Hitoshi Aihara
Publikováno v:
Scientific Reports
In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e186487a270509df02cc73dc8cfaec
https://doi.org/10.1038/srep16567
https://doi.org/10.1038/srep16567
Autor:
Annemiek Beverdam, Dagmar Wilhelm, Hirofumi Mizusaki, Josephine Bowles, Peter Koopman, Fred Martinson, Stephen T Bradford, Megan J. Wilson, Alexander N. Combes
Publikováno v:
Developmental Biology. 287(1):111-124
We have raised an antibody specifically recognizing endogenous mouse SRY protein and used it to investigate the molecular and cellular mode of action of SRY in testis determination. We find that expression of SRY protein closely mirrors the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bf710c9d86429ebf7ed581ba67798c
Autor:
Kiyoshi Shimada, Makoto Matsuyama, Tokuo Mukai, Kuniya Abe, Akihiko Shimono, Ken Ichirou Morohashi, Hirofumi Mizusaki, Katsuzumi Okumura
Publikováno v:
Genes to Cells. 10:421-434
Recent loss-of-function and gain-of-function studies have revealed that transcription factor Sox9 is required for testis formation by governing Sertoli cell differentiation, and thereafter regulating transcription of Sertoli marker genes. In the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635f98238a7dbbca801891aa3eb96f78
https://doi.org/10.1111/j.1365-2443.2005.00844.x
https://doi.org/10.1111/j.1365-2443.2005.00844.x
Autor:
Hidefumi Yoshioka, Ken Ichirou Morohashi, Etsuko Ariyoshi, Megumi Kasahara, Ken Kawabe, Hirofumi Mizusaki, Amanda Swain, Tokuo Mukai
Publikováno v:
Molecular Endocrinology. 17:507-519
Dax-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (NR0B1)] is an orphan nuclear receptor acting as a suppressor of Ad4 binding protein/steroidogenic factor 1 [Ad4BP/SF-1 (NR5A1)] and as an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2b64bcbd534337d4325bcb8fec84ea
https://doi.org/10.1210/me.2002-0362
https://doi.org/10.1210/me.2002-0362
Autor:
Hidefumi Yoshioka, Megumi Kasahara, Ken Kawabe, Taiga Suzuki, Ken Ichirou Morohashi, Hirofumi Mizusaki
Publikováno v:
The Genetics and Biology of Sex Determination: Novartis Foundation Symposium 244
It is well known that signals from growth factors regulate gene transcription thus initiating certain steps of cellular and tissue differentiation during development. In gonad differentiation several transcription factors have been identified as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad343a10a5ea9cacc4607aab260883d1
https://doi.org/10.1002/0470868732.ch7
https://doi.org/10.1002/0470868732.ch7
Autor:
Vincent R. Harley, Tara Davidson, Andrew H. Sinclair, Catherine M. Browne, Andrew Jackson, Peter Koopman, Dagmar Wilhelm, Hirofumi Mizusaki, Juan Carlos Polanco
Publikováno v:
Biology of the cell. 101(1)
Background information. SRY (sex-determining region Y), the master regulator of male development in mammals, has been studied extensively for more than 17 years, but how the SRY protein triggers the chain of events leading to testis development remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ac9dd2a2050e3a092ecfb0c311ba65
https://pubmed.ncbi.nlm.nih.gov/18588511
https://pubmed.ncbi.nlm.nih.gov/18588511
Autor:
Makoto, Matsuyama, Hirofumi, Mizusaki, Akihiko, Shimono, Tokuo, Mukai, Katsuzumi, Okumura, Kuniya, Abe, Kiyoshi, Shimada, Ken-ichirou, Morohashi
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 10(5)
Recent loss-of-function and gain-of-function studies have revealed that transcription factor Sox9 is required for testis formation by governing Sertoli cell differentiation, and thereafter regulating transcription of Sertoli marker genes. In the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5be2edb1e9b10b90453a14381e14f392
https://pubmed.ncbi.nlm.nih.gov/15836771
https://pubmed.ncbi.nlm.nih.gov/15836771
Autor:
Masahiro Shirakawa, Hideki Yamamoto, Tokuo Mukai, Hirofumi Mizusaki, Akira Kikuchi, Tomoko Komatsu, Shigetsugu Hatakeyama, Daichi Baba, Keiichi I. Nakayama, Hidesato Ogawa, Ken Ichirou Morohashi
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 18(10)
An orphan nuclear receptor, Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1), is essential for the development and function of steroidogenic tissues. To examine the transcriptional regulation of Ad4BP/SF-1, two-hybrid screening was performed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1adfbd1c2f3f264e6d13368905b7713
https://pubmed.ncbi.nlm.nih.gov/15192080
https://pubmed.ncbi.nlm.nih.gov/15192080