Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Hirofumi Kuroda"'
Autor:
Shin Ono, Masato Koga, Yuya Arimura, Takahiro Hatakeyama, Mai Kobayashi, Jun-ichi Sagara, Takahiko Nakai, Yoshikazu Horino, Hirofumi Kuroda, Hiroshi Oyama, Kazunari Arima
Publikováno v:
Molecules, Vol 28, Iss 7, p 3150 (2023)
We previously reported that Lys175 in the region of the active site of chymotrypsin (Csin) could be site-selectively modified by using an N-hydroxy succinimide (NHS) ester of the peptidyl derivative containing 1-amino-2-ethylphenylphosphonate dipheny
Externí odkaz:
https://doaj.org/article/3553faefa8914ce1b193d91d3b2181a2
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50009 (2012)
F-Box (FBX) proteins are encoded by a multigene family present in major lineages of eukaryotes. A number of FBX proteins are shown to be subunits of SCF complex, a type of E3 ligases composed of SKP1, CULLIN, FBX and RBX1 proteins. The Arabidopsis SK
Externí odkaz:
https://doaj.org/article/f7b492fffb9b4b63bc8f49e2f8dcff18
Autor:
Pi-Chen Hsu, Hirofumi Kuroda
Publikováno v:
Jungian Psychology in the East and West ISBN: 9781003168133
Jungian Psychology in the East and West
Jungian Psychology in the East and West
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87279bdaa58ea0380289aae4d0531575
https://doi.org/10.4324/9781003168133-18
https://doi.org/10.4324/9781003168133-18
Autor:
Yoshikazu Horino, Takahiko Nakai, Hirofumi Kuroda, Hiroshi Oyama, Hitoshi Abe, Ryuta Miyatake, Shin Ono, Masahito Umezaki
Publikováno v:
Biopolymers. 106:521-530
Diphenyl (α-aminoalkyl)phosphonates act as mechanism-based inhibitors against serine proteases by forming a covalent bond with the hydroxy group of the active center Ser residue. Because the covalent bond was found to be broken and replaced by 2-pyr
Autor:
Hirofumi Kuroda, Teiji Takigawa, Hiroyuki Chiba, Katsuya Tagami, Takashi Fukuyama, Akio Kayano
Publikováno v:
Organic Process Research & Development. 20:503-509
Here we examined the use of continuous flow conditions for the final assembly of eribulin mesylate aimed to avoid cryogenic condition. The diisobutylaluminum hydride reduction of ester 2 to aldehyde 3 and n-butyllithium-mediated coupling of aldehyde
Autor:
Naoki Takahashi, Hirofumi Kuroda, Takashi Kuromori, Takashi Hirayama, Motoaki Seki, Kazuo Shinozaki, Hiroaki Shimada, Minami Matsui
Publikováno v:
Plant & Cell Physiology. Jan2004, Vol. 45 Issue 1, p83-91. 9p.
Autor:
Yongbo Hu, James Cutter, Naoki Asai, Taichi Abe, Hyeong-Wook Choi, Teiji Takigawa, Taiju Nakamura, Thomas Noland, Masanori Mizuno, Atsushi Endo, Marc Pesant, Michael D. Lewis, Takao Omae, Bryan M. Lewis, Kazuhiro Yoshizawa, Francis G. Fang, Tomohiro Watanabe, Shawn McKenna, William J. Christ, Naoki Ozeki, Brian Austad, Gordon D. Wilkie, Hirofumi Kuroda, Trevor Lee Calkins, Manabu Kubota, Akio Kayano, Yumi Asai, John D. Orr, Matthew J. Schnaderbeck, Farid Benayoud, Yuki Komatsu, Robert Costanzo, Silvio Campagna, Taeko Suzuki, Charles E. Chase, Yuichi Kimoto
Publikováno v:
Synlett. 24:327-332
Multikilogram manufacturing process of the Halaven® C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.
Autor:
Hirofumi Kuroda, Huiming Zhang, Yuki Komatsu, Naoki Asakawa, Yongbo Hu, Akio Kayano, Takashi Hasebe, Takashi Kajima, Xiang Niu, Yorihisa Hoshino, Charles E. Chase, Francis G. Fang, Tomohiro Watanabe, Hiroyuki Ishizuka, Thomas Noland, Matthew J. Schnaderbeck, Thomas E. Horstmann, Naoki Asai, Mamoru Miyazawa, Katsuya Tagami, Brian Austad, Manabu Kubota, John D. Orr, Trevor Lee Calkins, Hiroyuki Chiba, Bryan M. Lewis
Publikováno v:
Synlett. 24:333-337
The evolution of the synthesis of Halaven® (E7389, INN eribulin mesylate) from a medicinal chemistry process to the execution of the final process on pilot scale is described. The completion of the synthesis of Halaven® from C1–C13 ester and C14
Autor:
Seigo Furuta, Hiroshi Oyama, Masahito Umezaki, Shin Ono, Toshiaki Yoshimura, Kazuya Doike, Junya Murai, Hirofumi Kuroda, Fumie Manzaki
Publikováno v:
Journal of Biological Macromolecules. 13:78-85
To establish a covalent chromatography system for purification of naturally occurring chymotrypsin-like serine proteases, a diphenyl 1-amino-2-phenylethylphosphonate derivative bearing Gly-Gly-Gly as a spacer was immobilized on the Sepharose 4FF gel.
Autor:
Keiichi Akabori, Kenichiro Kosugi, Seiichi Kawahara, Yoshimasa Yamamoto, Hirofumi Kuroda, Patjaree Suksawad
Publikováno v:
Journal of Applied Polymer Science. 122:2403-2414
High-proton-conductive polymer electrolyte with a nanomatrix channel was prepared by graft copolymerization of styrene onto deproteinized natural rubber followed by sulfonation with chlorosulfonic acid. First, natural rubber latex was purified with u