Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Hirofumi Kodama"'
Autor:
Hitoshi Iikura, Hirofumi Kodama, Haruhiko Sato, Takehisa Kitazawa, Yoshiyuki Ono, Yoshiaki Watanabe, Tohru Esaki, Toshiro Kozono, Masateru Ohta, Shojiro Kadono, Keiko Esaki, Masayuki Haramura, Kunihiro Hattori, Takaki Koga, Kazutaka Yoshihashi, Akihisa Sakamoto, Takuya Shiraishi
Publikováno v:
Letters in Drug Design & Discovery. 6:86-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ca41bad0fbed262f0a3d7a2373b83f
https://doi.org/10.2174/157018009787582606
https://doi.org/10.2174/157018009787582606
Autor:
Hitoshi Iikura, Masateru Ohta, Akihisa Sakamoto, Haruhiko Sato, Hirofumi Kodama, Toshiro Kozono, Keiko Esaki, Takehisa Kitazawa, Yoshiaki Watanabe, Yoshiyuki Ono, Takaki Koga, Takuya Shiraishi, Kazutaka Yoshihashi, Shojiro Kadono, Tohru Esaki, Kunihiro Hattori, Masayuki Haramura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4533-4537
Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. Compound 1 was discovered from focused screening of serine protease-directed compounds from our internal colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d05160a5dbc746644bce87a519a250
https://doi.org/10.1016/j.bmcl.2008.07.044
https://doi.org/10.1016/j.bmcl.2008.07.044
Autor:
Hirofumi Kodama, Yumiko Furuya, Tomomi Iwakiri, Kazuhiko Arimori, Manabu Okumura, Mizue Takemoto, Keishi Yamasaki, Nao Setoguchi, Muneaki Hidaka
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 32:898-905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e5f82375ccd4cf89b2a07d4f1d2577
https://doi.org/10.5649/jjphcs.32.898
https://doi.org/10.5649/jjphcs.32.898
Autor:
Hiromi Sasaki, Keishi Yamasaki, Muneaki Hidaka, Manabu Okumura, Masahide Asai, Tomomi Iwakiri, Kazuhiko Arimori, Ken-ichi Fujita, Tetsuya Ogikubo, Hirofumi Kodama
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 32:392-399
In view of the lack of information on the extent to which tea beverages inhibit the activity of human cytochrome P 450 3A (CYP 3A), we investigated their effect on the midazolam 1'-hydroxylation activity of CYP 3A contained in human liver microsomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1dedd0bfb91f2718702c3a4ef7f77d
https://doi.org/10.5649/jjphcs.32.392
https://doi.org/10.5649/jjphcs.32.392
Autor:
Kazuyuki Saito, Akio Fujimura, Yasuo Kodama, Hirofumi Kodama, Shunsuke Ono, Masae Kuranari, Kimiko Tsutsumi, Deborah F. Yaplee, Hiromi Takano-Ohmuro, Mizue Mutoh
Publikováno v:
Drugs in R & D. 6:21-34
Objective:This study evaluated the utilisation of human pharmacology studies with biomarkers for either efficacy or safety estimation conducted for new drug applications (NDAs) submitted to the Japanese regulatory authority, the Ministry of Health, L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36378881393a1dbc43f24c9095b69c49
https://doi.org/10.2165/00126839-200506010-00003
https://doi.org/10.2165/00126839-200506010-00003
Autor:
Nao Setoguchi, Manabu Okumura, Muneaki Hidaka, Keishi Yamasaki, Tomomi Iwakiri, Hirofumi Kodama, Kazuhiko Arimori, Yumiko Furuya
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 31:537-543
We investigated the change in drug concentrations in serum stored in sterilized vacuum tubes for serum separation. The serum concentrations of seven drugs-phenytoin, phenobarbital, carbamazepine, vancomycin, valproate, theophylline and digoxin-were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2252ed8ec65850aedf3195073155e24
https://doi.org/10.5649/jjphcs.31.537
https://doi.org/10.5649/jjphcs.31.537
Autor:
Yumiko Furuya, Norito Takamura, Keiichi Kawai, Manabu Okumura, Keishi Yamasaki, Noriyuki Kuga, Muneaki Hidaka, Hirofumi Kodama, Ryuuichi Nishii, Kazuhiko Arimori, Tomomi Iwakiri
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:549-552
The effects of amino-acid fluids on ligand binding to human serum albumin (HSA) were investigated by fluorescence and ultrafiltration techniques. Warfarin and dansylsarcosine were used as the site marker fluorescence probes for site I and site II of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3569aac3c475b31a1aee232af7630f86
https://doi.org/10.1248/bpb.28.549
https://doi.org/10.1248/bpb.28.549
Autor:
Masateru Ohta, Yoshiaki Watanabe, Hirofumi Kodama, Toshiro Kozono, Takuya Shiraishi, Susumu Itoh, Haruhiko Sato, Takaki Koga, Masayuki Haramura, Yasufumi Kikuchi, Kunihiro Hattori, Akihisa Sakamoto, Naohiro Yabuta, Toru Esaki, Masayoshi Oh-eda, Shojiro Kadono
Publikováno v:
Biochemical and Biophysical Research Communications. 324:1227-1233
The 3D structure of human factor VIIa/soluble tissue factor in complex with a peptide mimetic inhibitor, propylsulfonamide-D-Thr-Met-p-aminobenzamidine, is determined by X-ray crystallography. As compared with the interactions between thrombin and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e64d66cd4fa9c3521e5edf275db3e34
https://doi.org/10.1016/j.bbrc.2004.09.182
https://doi.org/10.1016/j.bbrc.2004.09.182
Autor:
Shunsuke Ono, Kimiko Tsutsumi, Akio Fujimura, Takuhiro Yamaguchi, Masae Kuranari, Hirofumi Kodama, Yasuo Kodama
Publikováno v:
American Journal of Health-System Pharmacy. 59:835-840
The binding of valproic acid to serum proteins in pediatric and adult patients was studied. Serum samples were obtained from 48 Japanese pediatric patients with epilepsy (group A) and 48 Japanese adult patients with epilepsy (group B) receiving valpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626b7253d84c1f3fc0aca7c05c6f7797
https://doi.org/10.1093/ajhp/59.9.835
https://doi.org/10.1093/ajhp/59.9.835
Autor:
Manabu Okumura, Kazuhiko Arimori, Muneaki Hidaka, Tomomi Iwakiri, Norito Takamura, Hirofumi Kodama
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 27:541-547
Anthracyclines have been used to cure a variety of cancers, and they are one of the most effective anti-cancer drugs. However, due to the simultaneous occurrence of serious side effects, successful chemotherapy is difficult to administer in clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7249d418730f5dfaa3242d772765f9c
https://doi.org/10.5649/jjphcs.27.541
https://doi.org/10.5649/jjphcs.27.541