Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Hirofumi AKARI"'
Autor:
Kou Hiraga, Tomoya Kitamura, Madoka Kuramitsu, Megumi Murata, Kenta Tezuka, Kazu Okuma, Isao Hamaguchi, Hirofumi Akari, Takuo Mizukami
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-9 (2024)
Abstract Background Simian T-cell leukemia virus type 1 (STLV-1) is a retrovirus closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia (ATL). It has been shown that Japanese macaques (Macaca fusc
Externí odkaz:
https://doaj.org/article/dfe46828b93a43d2ac94f1207a8e6d3d
Publikováno v:
Bio-Protocol, Vol 13, Iss 14 (2023)
An efficient cell culture system for hepatitis B virus (HBV) is indispensable for research on viral characteristics and antiviral agents. Currently, for HBV infection assays in cell culture, HBV genome-integrated cell line–derived viruses are commo
Externí odkaz:
https://doaj.org/article/46a296824ec241caac7057d381d082af
Autor:
Ayaka Washizaki, Asako Murayama, Megumi Murata, Tomoko Kiyohara, Keigo Yato, Norie Yamada, Hussein Hassan Aly, Tomohisa Tanaka, Kohji Moriishi, Hironori Nishitsuji, Kunitada Shimotohno, Yasumasa Goh, Ken J. Ishii, Hiroshi Yotsuyanagi, Masamichi Muramatsu, Koji Ishii, Yoshimasa Takahashi, Ryosuke Suzuki, Hirofumi Akari, Takanobu Kato
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The hepatitis B vaccine is recognised as the most effective approach in reducing hepatitis-B-related morbidity; vaccine-escape mutations are however capable of infecting vaccinated individuals. In this work, authors aim to establish a hepatitis B vac
Externí odkaz:
https://doaj.org/article/eab3ce3f48a74871a664e7bab6a1dc86
Autor:
Atsuhiko Hasegawa, Megumi Murata, Tomoka Fujikawa, Kuniko Katagiri, Yoshiko Nagano, Takao Masuda, Madoka Kuramitsu, Shinsuke Nakajima, Jun-Ichi Fujisawa, Kazu Okuma, Poonam Grover, Maureen Kidiga, Hirofumi Akari, Mari Kannagi
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011104 (2023)
A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs),
Externí odkaz:
https://doaj.org/article/3ab840225829417bbfff96d171c56a63
Autor:
Yoshihiro Iwamoto, Yohei Seki, Kahoru Taya, Masahiro Tanaka, Shoichi Iriguchi, Yasuyuki Miyake, Emi E. Nakayama, Tomoyuki Miura, Tatsuo Shioda, Hirofumi Akari, Akifumi Takaori-Kondo, Shin Kaneko
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 262-273 (2021)
Because of their close biological similarity to humans, non-human primate (NHP) models are very useful for the development of induced pluripotent stem cell (iPSC)-based cell and regenerative organ transplantation therapies. However, knowledge on the
Externí odkaz:
https://doaj.org/article/2180421f132f483ba7f7b17b2bd8d31e
Autor:
Megumi Murata, Jun-ichirou Yasunaga, Ayaka Washizaki, Yohei Seki, Madoka Kuramitsu, Wei Keat Tan, Anna Hu, Kazu Okuma, Isao Hamaguchi, Takuo Mizukami, Masao Matsuoka, Hirofumi Akari
Publikováno v:
Retrovirology, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract Background Simian T-cell leukemia virus type 1 (STLV-1) is disseminated among various non-human primate species and is closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia and HTLV-1-as
Externí odkaz:
https://doaj.org/article/e989182aae0a447ebebe10888bdbda38
Autor:
Kei Miyakawa, Satoko Matsunaga, Masaru Yokoyama, Masako Nomaguchi, Yayoi Kimura, Mayuko Nishi, Hirokazu Kimura, Hironori Sato, Hisashi Hirano, Tomohiko Tamura, Hirofumi Akari, Tomoyuki Miura, Akio Adachi, Tatsuya Sawasaki, Naoki Yamamoto, Akihide Ryo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interactio
Externí odkaz:
https://doaj.org/article/6102736bfc484ca3b0b10f8fb9a53fa8
Autor:
Mikiko Izaki, Jun-Ichirou Yasunaga, Kisato Nosaka, Kenji Sugata, Hayato Utsunomiya, Youko Suehiro, Takafumi Shichijo, Asami Yamada, Yasuhiko Sugawara, Taizo Hibi, Yukihiro Inomata, Hirofumi Akari, Anat Melamed, Charles Bangham, Masao Matsuoka
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009271 (2021)
Human T-cell leukemia virus type 1 (HTLV-1) spreads through cell contact. Therefore, this virus persists and propagates within the host by two routes: clonal proliferation of infected cells and de novo infection. The proliferation is influenced by th
Externí odkaz:
https://doaj.org/article/aa6ab0195b1d47f492253da164ea1e2f
Autor:
Hirotaka Sato, Tomoyuki Murakami, Ryosuke Matsuura, Masako Abe, Seiji Matsuoka, Yoko Yashiroda, Minoru Yoshida, Hirofumi Akari, Yosuke Nagasawa, Masami Takei, Yoko Aida
Publikováno v:
Viruses, Vol 14, Iss 6, p 1321 (2022)
The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, arrests the cell cycle of the G2 phase, and this Vpr-mediated G2 arrest is implicated in an efficient HIV-1 spread in monocyte-derived macrophages. Here, we screened new candidat
Externí odkaz:
https://doaj.org/article/94658bd67afb4a9dac726c1f4b8cfb6a
Autor:
Yohei Seki, Tomoya Kitamura, Kenta Tezuka, Megumi Murata, Hirofumi Akari, Isao Hamaguchi, Kazu Okuma
Publikováno v:
Viruses, Vol 14, Iss 4, p 740 (2022)
Human T-cell leukemia virus type 1 (HTLV-1) causes serious and intractable diseases in some carriers after infection. The elimination of infected cells is considered important to prevent this onset, but there are currently no means by which to accomp
Externí odkaz:
https://doaj.org/article/340cc07195964679badeaaa08ae8cb64