Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Hirofumi AIBA"'
Autor:
Hokuto Ohtsuka, Yoshiko Hatta, Kana Hayashi, Takafumi Shimasaki, Yoko Otsubo, Yurika Ito, Yu Tsutsui, Nobutake Hattori, Akira Yamashita, Hiroshi Murakami, Hirofumi Aiba
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 51-64 (2022)
Cyclins are degraded by the anaphase-promoting complex/cyclosome (APC/C)-mediated proteasome in normal mitosis. We showed that Cdc13 (cyclin B) is also degraded by macroautophagy/autophagy in sulfur-deficient fission yeast. Sulfur depletion causes G2
Externí odkaz:
https://doaj.org/article/2cddbfddda1940d9ad3021797f5970cf
Publikováno v:
MicrobiologyOpen, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract The fission yeast Schizosaccharomyces pombe employs two main strategies to adapt to the environment and survive when starved for nutrients. The strategies employ sporulation via sexual differentiation and extension of the chronological lifes
Externí odkaz:
https://doaj.org/article/d4711eea1b1a4384ad241d30083a76c5
Autor:
Hokuto Ohtsuka, Mikuto Kobayashi, Takafumi Shimasaki, Teppei Sato, Genki Akanuma, Yasuyuki Kitaura, Yoko Otsubo, Akira Yamashita, Hirofumi Aiba
Publikováno v:
MicrobiologyOpen, Vol 10, Iss 2, Pp n/a-n/a (2021)
Abstract Nutrients including glucose, nitrogen, sulfur, zinc, and iron are involved in the regulation of chronological lifespan (CLS) of yeast, which serves as a model of the lifespan of differentiated cells of higher organisms. Herein, we show that
Externí odkaz:
https://doaj.org/article/172c9bf841174a39ae72131491ac3fd3
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 829-833 (2014)
We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1+ that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an incre
Externí odkaz:
https://doaj.org/article/efad2aea4be5403b8edd934639aa2c20
Autor:
Hokuto Ohtsuka, Takuma Matsumoto, Takahiro Mochida, Takafumi Shimasaki, Masatoshi Shibuya, Yoshihiko Yamamoto, Hirofumi Aiba
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 86(6):775-779
Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00e0b8d6ab14279dd2be516f4c5bea1
https://nagoya.repo.nii.ac.jp/records/2003773
https://nagoya.repo.nii.ac.jp/records/2003773
Autor:
Hokuto Ohtsuka, Hiroki Sakata, Yuto Kitazaki, Masanobu Tada, Takafumi Shimasaki, Yoko Otsubo, Yasukichi Maekawa, Mikuto Kobayashi, Kazuki Imada, Akira Yamashita, Hirofumi Aiba
Publikováno v:
Journal of Cell Science. 136
In Schizosaccharomyces pombe, ecl family genes are induced by several signals, such as starvation of various nutrients, including sulfur, amino acids and Mg2+, and environmental stress, including heat or oxidative stress. These genes mediate appropri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f49778b5afedcd056de56cf27e5d86b
https://doi.org/10.1242/jcs.260759
https://doi.org/10.1242/jcs.260759
Autor:
Teppei Maruyama, Kanako Hayashi, Kotaro Matsui, Yasukichi Maekawa, Takafumi Shimasaki, Hokuto Ohtsuka, Saitoh Shigeaki, Hirofumi Aiba
Publikováno v:
The Journal of General and Applied Microbiology. 68:270-277
Fission yeast, Schizosaccharomyces pombe, possesses eight hexose transporters, Ght1~8. In order to clarify the role of each hexose transporter on glucose uptake, a glucose uptake assay system was established and the actual glucose uptake activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4679e7a6abb8e49676b3e8854e8f266e
https://doi.org/10.2323/jgam.2022.05.006
https://doi.org/10.2323/jgam.2022.05.006
Autor:
Kotaro Matsui, Hirofumi Aiba, Kunio Ihara, Hokuto Ohtsuka, Keisuke Okamoto, Takafumi Shimasaki, Tomoka Hasegawa, Kazuhiro Aoki, Yuhei Goto
Publikováno v:
Genes to Cells. 26:967-978
Fission yeast is a good model organism for the study of lifespan. To elucidate the mechanism, we screened for long-lived mutants. We found a nonsense mutation in the ksg1+ gene, which encodes an ortholog of mammalian PDK1 (phosphoinositide-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a648cae439b160e57ac8ae2c7ddfda1e
https://doi.org/10.1111/gtc.12897
https://doi.org/10.1111/gtc.12897
Autor:
Hokuto Ohtsuka, Hiroki Sakata, Yuto Kitazaki, Masanobu Tada, Takafumi Shimasaki, Yoko Otsubo, Yasukichi Maekawa, Mikuto Kobayashi, Kazuki Imada, Akira Yamashita, Hirofumi Aiba
Publikováno v:
Journal of Cell Science; Mar2023, Vol. 136 Issue 6, p1-13, 13p
Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast)
Publikováno v:
Molecular Microbiology
So far, more than 70 genes involved in the chronological lifespan (CLS) of Schizosaccharomyces pombe (fission yeast) have been reported. In this mini‐review, we arrange and summarize these genes based on the reported genetic interactions between th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a34ffd4ca388139a12c9a48c018d8f
https://doi.org/10.1111/mmi.14627
https://doi.org/10.1111/mmi.14627