Intermittent hypoxia by obstructive sleep apnea is significantly associated with electro-anatomical remodeling of the left atrium preceding structural remodeling in patients with atrial fibrillation

Autor: Yasuyuki Takada, Kazuki Shiina, Shunichiro Orihara, Yoshifumi Takata, Takamichi Takahashi, Junya Kani, Takahiro Kusume, Muryo Terasawa, Hiroki Nakano, Yukio Saitoh, Yoshinao Yazaki, Hirofumi Tomiyama, Taishiro Chikamori, Kazuhiro Satomi

Publikováno v: International Journal of Cardiology: Heart & Vasculature, Vol 54, Iss , Pp 101490- (2024)

Background: Obstructive sleep apnea (OSA) is one of the risk factors for atrial fibrillation (AF). However, the mechanism underlying the atrial structural and electro-anatomical remodeling by OSA has not yet been clearly elucidated. Methods: This stu

Externí odkaz: https://doaj.org/article/9ee40394015d4c339394f1c3842dcdde

Lack of impact of ipragliflozin on endothelial function in patients with type 2 diabetes: sub-analysis of the PROTECT study

Autor: Shinji Kishimoto, Yukihito Higashi, Takumi Imai, Kazuo Eguchi, Kazuo Fukumoto, Hirofumi Tomiyama, Koji Maemura, Atsushi Tanaka, Koichi Node, the PROTECT investigators

Publikováno v: Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-9 (2023)

Abstract Background We assessed the impact of 24 months of treatment with ipragliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on endothelial function in patients with type 2 diabetes as a sub-analysis of the PROTECT study. Methods In t

Externí odkaz: https://doaj.org/article/cc4bf384705f412c88f0103893b3ba8e

Effects of Low-Dose Colchicine on Serum High-Sensitivity C-Reactive Protein Level in Coronary Artery Disease Patients with Type 2 Diabetes Mellitus and Enhanced Inflammatory Response Protocol for a Randomized, Double-Blind, Placebo-Controlled, Phase 2, Dose-Finding Study

Autor: Yoshikazu Miwa, Akiko Mutoh, Takeshi Morimoto, Yumi Ikehara, Takanori Yasu, Shinji Koba, Junya Ako, Yukihito Higashi, Masato Kajikawa, Hiroki Uehara, Kazuo Ishikawa, Ichiro Sakuma, Hirofumi Tomiyama, Koichi Node, Yuji Kumagai, Shinichiro Ueda

Publikováno v: Biomedicine Hub, Vol 7, Iss 3, Pp 156-164 (2022)

Although cardiovascular mortality in Japan is lower than in other industrialized countries, clinical outcomes in coronary artery disease (CAD) patients with type 2 diabetes mellitus (T2DM) remain poor despite multiple evidence-based drug therapies an

Externí odkaz: https://doaj.org/article/1d2f4f70eadd47a5b28e7b5f575faf36

Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participantsResearch in context

Autor: Yao Lu, Sophia J. Kiechl, Jie Wang, Qingbo Xu, Stefan Kiechl, Raimund Pechlaner, David Aguilar, Khamis M. Al-Hashmi, Rafael O. Alvim, Ibrahim S. Al-Zakwani, Christina Antza, Arrigo F.G. Cicero, Maja Avramovska, Petar Avramovski, Hyun Jae Baek, Magnus Bäck, Kent Bailey, Marcelo P. Baldo, Rosângela F.L. Batista, Athanasios Benetos, Emelia J. Benjamin, Daniel Bia, Claudio Borghi, Shani Botha-Le Roux, Yolandi Breet, David Burgner, Viviane C. Cardoso, Marina Cecelja, Indre Ceponiene, Chen-Huan Chen, Michael Cheung, Hao-min Cheng, Jaegeol Cho, Phil Chowienczyk, Eduardo B. Coelho, Orsolya Cseprekal, Amilcar BT Da Silva, Frédéric Dallaire, Roberto De Sá Cunha, Alejandro Diaz, Albano V.L. Ferreira, Jean Ferrières, Yoshihiko Furuta, Manuel A. Gómez-Marcos, Leticia Gómez-Sánchez, Julian Halcox, Craig Hanis, Karl-Heinz Herzig, Edgar Jaeggi, Maryam Kavousi, Ursula Kiechl-Kohlendorfer, Hack-Lyoung Kim, Mi-Kyung Kim, Yu-Mi Kim, Eva Kis, Michael Knoflach, Vasilios Kotsis, Teruhide Koyama, Michaela Kozakova, Ruan Kruger, Iftikhar J. Kullo, Sun-Seog Kweon, Irene Lambrinoudaki, Chang Liu, Markus Loeffler, Jeongok G. Logan, Jane Maddock, Pedro Magalhães, João Maldonado, Francesco U.S. Mattace-Raso, Alex Messner, Michelle L. Meyer, Jie Mi, José Geraldo Mill, Gary F. Mitchell, Jian-Jun Mu, Iram F. Muhammad, Johannes Nairz, Atsushi Nakagomi, Mieko Nakamura, Peter M. Nilson, Toshiharu Ninomiya, Carlo Palombo, Alexandre C. Pereira, Telmo Pereira, Daniel P. Capingana, Anna K. Poon, Nicole Probst-Hensch, Arshed A. Quyyumi, George S. Reusz, Moo-Yong Rhee, Cecilia C.C. Ribeiro, Ernst Rietzschel, Paulo R.H. Rocha, Enrique Rodilla, Marta Rojek, Jean-Bernard Ruidavets, Joost H.W. Rutten, Yasuaki Saijo, Paolo Salvi, Arno Schmidt-Trucksäss, Markus Scholz, Min-Ho Shin, Patrick Segers, Kimon Stamatelopoulos, Irina D. Strazhesko, Minoru Sugiura, Olga N. Tkacheva, Hirofumi Tomiyama, Elaine M. Urbina, Inge C.L. van den Munckhof, Ramachandran S. Vasan, Melissa A. Wake, Goya Wannamethee, Andrew Wong, Akira Yamashina, Yinkun Yan, Divanei Zaniqueli, Fang Zhu, Yanina Zócalo

Publikováno v: EBioMedicine, Vol 92, Iss , Pp 104619- (2023)

Summary: Background: Arterial stiffening is central to the vascular ageing process and a powerful predictor and cause of diverse vascular pathologies and mortality. We investigated age and sex trajectories, regional differences, and global reference

Externí odkaz: https://doaj.org/article/28b0f5a01486441ea49ee7b2648621f1

Effect of canagliflozin on N-terminal pro-brain natriuretic peptide in patients with type 2 diabetes and chronic heart failure according to baseline use of glucose-lowering agents

Autor: Atsushi Tanaka, Shigeru Toyoda, Takumi Imai, Kazuki Shiina, Hirofumi Tomiyama, Yasushi Matsuzawa, Takahiro Okumura, Yumiko Kanzaki, Katsuya Onishi, Arihiro Kiyosue, Masami Nishino, Yasushi Sakata, Koichi Node, the CANDLE trial investigators

Publikováno v: Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-12 (2021)

Abstract Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of a deterioration in heart failure (HF) and mortality in patients with a broad range of cardiovascular risks. Recent guidelines recommend considering the use of

Externí odkaz: https://doaj.org/article/2923e3885c0d4742819b69acf51899ab