Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Hirofumi, Terasawa"'
Autor:
Takeshi Jimbo, Tsunehiko Soga, Motoko Nagata, Yasuyuki Takeda, Chiho Ono, Michio Iwahana, Hirofumi Terasawa, Kouichi Uoto, Noriko Tanaka, Ryo Atsumi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3209-3215
To improve the metabolic stability of 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogues. Most of the synthetic compounds maintained excellent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be3909537e36f1c0dd2fbd5f7d0a637
https://doi.org/10.1016/j.bmcl.2004.03.109
https://doi.org/10.1016/j.bmcl.2004.03.109
Autor:
Yasuyuki, Takeda, Toshiharu, Yoshino, Kouichi, Uoto, Jun, Chiba, Takashi, Ishiyama, Michio, Iwahana, Takeshi, Jimbo, Noriko, Tanaka, Hirofumi, Terasawa, Tsunehiko, Soga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:185-190
We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9beta-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7be4c16026aa2a1ce98ef20f7fc984
https://doi.org/10.1016/s0960-894x(02)00891-0
https://doi.org/10.1016/s0960-894x(02)00891-0
Autor:
Toshiharu Yoshino, Kouichi Uoto, Takeshi Jimbo, Shin Iimura, Satoru Ohsuki, Tsunehiko Soga, Jun Chiba, Michio Iwahana, Hirofumi Terasawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:407-410
To improve cytotoxicity of 10-deoxy-10-C-morpholinoethyl docetaxel analogues against various tumor cell lines including resistant cells expressing P-glycoprotein (P-gp), we modified the 7-hydroxyl group to hydrophobic groups (methoxy, deoxy, 6,7-olef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09f367001b2cd827d52f43b22d99048c
https://doi.org/10.1016/s0960-894x(00)00682-x
https://doi.org/10.1016/s0960-894x(00)00682-x
Autor:
Keiki Sato, Yasuyoshi Kawato, Hirofumi Terasawa, Y. Hirota, Kouichi Uoto, Satoru Ohsuki, Masamichi Sugimori, Ikuo Mitsui, Akio Ejima
Publikováno v:
Journal of Medicinal Chemistry. 41:2308-2318
Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedländer condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0086e00c4f0cd440a5d654de0cee6be3
https://doi.org/10.1021/jm970765q
https://doi.org/10.1021/jm970765q
Autor:
Shuichi Ando, Tsunehiko Soga, Ikuo Mitsui, Hirofumi Terasawa, Kouichi Uoto, Haruhiro Takenoshita, Yasuhide Hirota, Toshiharu Yoshino
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:770-776
To develop non-prodrugs of taxoids with satisfactory stability in vivo, high water-solubility, and potent antitumor activity, we prepared several 10-O-sec-aminoethyl docetaxel analogs (3) and evaluated their cytotoxicity against mouse leukemia and hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b57cf8754b51c033a35a13f828c8b66
https://doi.org/10.1248/cpb.46.770
https://doi.org/10.1248/cpb.46.770
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2991-2996
To investigate the effect of the C-18 position of docetaxel in its cytotoxic activity, 18-modified docetaxel analogs were synthesized for the first time from the 18-brominated baccatin derivatives. All of these analogs were found to be less active th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd46b4a0f0e011a5ccd9324eae0d5f04
https://doi.org/10.1016/s0960-894x(97)10128-7
https://doi.org/10.1016/s0960-894x(97)10128-7
Autor:
Masamichi Sugimori, Satoru Ohsuki, Yasuhide Hirota, Eiji Kumazawa, Masashi Aonuma, Kouichi Uoto, Hirofumi Terasawa, Akio Ejima, Ikuo Mitsui, Keiki Sato
Publikováno v:
Japanese Journal of Cancer Research : Gann
CPT‐11, a semisynthetic derivative of camptothecin, exhibited strong antitumor activity against lymphoma, lung cancer, colorectal cancer, gastric cancer, ovarian cancer, and cervical cancer. CPT‐11 is a pro‐drug that is converted to an active m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deebf591f2521e13b34c6191e4d7992
https://doi.org/10.1111/j.1349-7006.1995.tb02468.x
https://doi.org/10.1111/j.1349-7006.1995.tb02468.x
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf960a289a7b5c7fdefdcf50cf761d3
https://doi.org/10.1002/chin.199218318
https://doi.org/10.1002/chin.199218318
Autor:
Hirofumi Terasawa, K Matsumoto, Masamichi Sugimori, Yasuyoshi Kawato, Satoru Ohsuki, Akio Ejima, M Yasuoka, Hiroaki Tagawa
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d7012f6e11234571c05dd4370420049
https://doi.org/10.1002/chin.199425142
https://doi.org/10.1002/chin.199425142
Autor:
Kouichi Uoto, Shin Iimura, Takashi Ishiyama, Satoru Ohsuki, Hirofumi Terasawa, Haruhiro Takenoshita, Tsunehiko Soga, Ikuo Mitsui, Y. Hirota
Publikováno v:
ChemInform. 29
To investigate the role of the 2'-hydroxy group at the C-13 side chain of docetaxel in the antitumor activity, we prepared several 2',2'-difluoro derivatives of docetaxel and evaluated their cytotoxicity against mouse leukemia and human tumor cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::086fec225b515a690c2296da4f4795e2
https://doi.org/10.1002/chin.199818200
https://doi.org/10.1002/chin.199818200