Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hiroe Sawai"'
Autor:
Hiroe Sawai, Hirokazu Tanaka, Teruo Oku, Shigeki Satoh, Yuki Sawada, Noriaki Inamura, Masayuki Asano, Hiroshi Kayakiri, Chie Hatori, Yoshito Abe, Ichiro Aramori, Takayuki Inoue
Publikováno v:
Journal of Medicinal Chemistry. 41:4587-4598
In recent articles we reported the identification of a series of 8-[[2, 6-dichloro-3-[N-methyl-N-[(E)-(substituted)acryloylglycyl]amino]++ +benzy l]oxy]-2-methylimidazo[1,2-a]pyridines as the first orally active non-peptide bradykinin (BK) B2 recepto
Autor:
Masayuki Asano, Hiroe Sawai, Chie Hatori, Noriaki Inamura, Tatsujiro Fujiwara, Kunio Nakahara
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 76:1051-1055
It is speculated that bradykinin may play an important role in asthma. Thus, bradykinin receptor antagonists may have therapeutic potential against asthma. Orally active bradykinin antagonists would be more desirable for the treatment of the disease.
Autor:
Hirokazu Tanaka, Noriaki Inamura, Chie Hatori, Yoshito Abe, Masayuki Asano, Takayuki Inoue, Hiroe Sawai, Yuki Sawada, Hiroshi Kayakiri, Teruo Oku, Shigeki Satoh
Publikováno v:
Journal of Medicinal Chemistry. 41:4053-4061
Recently we reported the identification of a series of 8-[[3-(N-acylglycyl-N-methylamino)-2, 6-dichlorobenzyl]oxy]-3-halo-2-methylimidazo[1,2-a]pyridines as the first orally active non-peptide bradykinin (BK) B2 receptor antagonists (1-3). These comp
Autor:
Hiroe Sawai, Hiroshi Kayakiri, Takayuki Inoue, Kunio Nakahara, Yuki Sawada, Masayuki Asano, Shigeki Satoh, Chie Hatori, Yoshito Abe, Shigeru Johki, Noriaki Inamura, Teruo Oku, Tsuyoshi Mizutani
Publikováno v:
British Journal of Pharmacology. 124:441-446
1. The nonpeptide bradykinin (BK) B2 receptor antagonist, FR165649 (8-[2,6-dichloro-3-[N-[(E)-4-(N-methylcarbamoyl)cinnamidoacetyl ]-N-methylamino]benzyloxy]-2-methylquinoline), and agonist, FR190997 (8-[2,6-dichloro-3-[N-[(E)-4-(N-methylcarbamoyl) c
Autor:
Kunio Nakahara, Chie Hatori, Masayuki Asano, Hiroe Sawai, Noriaki Inamura, Tatsujiro Fujiwara
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 76:1051-1055
On emet l'hypothese que la bradykinine pourrait jouer un role important dans l'asthme. Ainsi, les antagonistes des recepteurs de la bradykinine pourraient avoir un pouvoir therapeutique en regard de l'asthme. Les antagonistes de la bradykinine oralem
Autor:
Hiroe Sawai, Kunio Nakahara, Chie Hatori, Jiro Hirosumi, Masayuki Asano, Noriaki Inamura, Tatsujiro Fujiwara
Publikováno v:
British Journal of Pharmacology. 122:1436-1440
1 The effects of a novel, potent and orally active nonpeptide bradykinin B2 receptor antagonist, FR167344 (N -[N -[3 -[(3 - bromo- 2 -methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4-dichlorophenyl]-N-methylaminocarbonylmethyl]-4-(dimethylaminocarbony
Autor:
Shigeki Satoh, Hiroe Sawai, Hitoshi Kojo, Noriyuki Morikawa, Teruo Oku, Yoshitada Notsu, Tsuyoshi Mizutani, Noriaki Inamura, Ichiro Aramori, Yuki Sawada, Chie Hatori, Yoshito Abe, Hiroshi Kayakiri, Takayuki Inoue, Masayuki Asano, Junko Zenkoh, Kunio Nakahara
Publikováno v:
Molecular Pharmacology. 52:16-20
Kinins, members of a family of peptides released from kininogens by the action of kallikreins, exhibit a variety of biological activities including vasodilation, increased vascular permeability, contraction of smooth muscle cells, and activation of s
Autor:
Kunio Nakahara, Teruo Oku, Noriaki Inamura, Masayuki Asano, Takayuki Inoue, Akira Katayama, Hiroe Sawai, Hiroshi Kayakiri, Chie Hatori, Yoshito Abe, Masakuni Okuhara, Tatsujiro Fujiwara, Yuki Sawada, Shigeki Satoh
Publikováno v:
British Journal of Pharmacology. 120:617-624
1. An orally active, nonpeptide bradykinin (BK) B2 receptor antagonist, FR173657 (E)-3-(6-acetamido-3-pyridyl)-N-[N-[2-4-dichloro-3-[(2-methyl-8-quinolin yl) oxymethyl]phenyl]-N-methylaminocarbonyl-methyl] acrylamide) has been identified. 2. This com
Autor:
Hiroe Sawai-Nakayama, Masahiko Matsuo, Seitaro Mutoh, Yasue Maeda, Toshitaka Manda, Katsunori Imazumi, Hisashi Yamakuni
Publikováno v:
European journal of pharmacology. 442(3)
We evaluated the antiemetic activity of resiniferatoxin, an ultrapotent capsaicin analogue, on cisplatin- and apomorphine-induced emesis in dogs, and on cisplatin-induced acute and delayed emesis in ferrets. In the dog, resiniferatoxin (10 microg/kg,
Autor:
Hiroe Sawai, Noriaki Inamura, Hitoshi Kojo, Masayuki Asano, Morita Iwami, Yoshitada Notsu, Yuki Sawada, Tsuyoshi Mizutani, Kunio Nakahara, Shigeki Satoh, Noriyuki Morikawa, Hiroshi Kayakiri, Teruo Oku, Chie Hatori, Yoshito Abe, Junko Zenkoh, Takayuki Inoue, Ichiro Aramori
Publikováno v:
Immunopharmacology. 45(1-3)
Kinins, members of a family of peptides released from kininogens by the action of kallikreins, have been implicated in a variety of biological activities including vasodilation, increased vascular permeability, contraction of smooth muscle cells and