Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hiroe Amou"'
Autor:
Kumiko Kagawa, Ayako Nakano, Hirokazu Miki, Asuka Oda, Hiroe Amou, Kyoko Takeuchi, Shingen Nakamura, Takeshi Harada, Shiro Fujii, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto, Masahiro Abe
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31594 (2012)
TNF-related apoptosis-inducing ligand/Apo2 ligand (TRAIL/Apo2L) selectively induces apoptosis in various cancer cells including myeloma (MM) cells. However, the susceptibility of MM cells to TRAIL is largely low in most of MM cells by yet largely unk
Externí odkaz:
https://doaj.org/article/23327e8b385341959bac799d3daf14ee
Autor:
Ayako Nakano, Daisuke Tsuji, Hirokazu Miki, Qu Cui, Salah Mohamed El Sayed, Akishige Ikegame, Asuka Oda, Hiroe Amou, Shingen Nakamura, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kyoko Takeuchi, Akira Sakai, Shuji Ozaki, Kazuma Okano, Takahiro Nakamura, Kohji Itoh, Toshio Matsumoto, Masahiro Abe
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27222 (2011)
Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps. Because cancer cells produce ATP mostly through glycolysis, in the present study we explored t
Externí odkaz:
https://doaj.org/article/1371243487bd4862b795ae3496a1cf00
Autor:
Kyoko Takeuchi, Masahiro Abe, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Shinsuke Kido, Takeshi Harada, Osamu Tanaka, Hirokazu Miki, Shingen Nakamura, Ayako Nakano, Kumiko Kagawa, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9870 (2010)
BACKGROUND: Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced. TGF-beta, a potent inhibitor of terminal osteobl
Externí odkaz:
https://doaj.org/article/1c16fdab5fd14332a7cc2a2f64d95ecc
Publikováno v:
Mycoscience. 57:181-186
A biosynthetic pathway for (E)-methyl cinnamate formation was evaluated in Tricholoma matsutake by tracer experiments using 13C- and 2H-labeled precursors. One hundred percent selective 13C incorporation was observed when l -[1,2,3,4,5,6,7,8,9-13C9,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ede6d052b7f41f1d9d1a0495a028fd
https://doi.org/10.1016/j.myc.2016.01.001
https://doi.org/10.1016/j.myc.2016.01.001
Autor:
Kyoko Takeuchi, Shingen Nakamura, Kumiko Kagawa, Toshio Matsumoto, Asuka Oda, Shinsuke Kido, Ayako Nakano, Shuji Ozaki, Hirokazu Miki, Keiichiro Watanabe, Masahiro Hiasa, Shiro Fujii, Hiroe Amou, Takeshi Harada, Masahiro Abe
Publikováno v:
International Journal of Hematology. 98:66-73
Endoplasmic reticulum (ER) stress is induced in matrix-producing osteoblasts and plays an essential role in osteoblastogenesis. Although the bone anabolic activity of proteasome inhibitors has been demonstrated, the roles of ER stress induced by prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d392442fe423089185292b164763336
https://doi.org/10.1007/s12185-013-1367-z
https://doi.org/10.1007/s12185-013-1367-z
Autor:
Kyoko Takeuchi, Shingen Nakamura, Shiro Fujii, Takeshi Harada, Kumiko Kagawa, Hiroe Amou, Masahiro Abe, Ayako Nakano, Shuji Ozaki, Hirokazu Miki, Asuka Oda, Toshio Matsumoto
Publikováno v:
Journal of Bioenergetics and Biomembranes. 44:31-38
Hexokinase II (HKII), a key enzyme of glycolysis, is widely over-expressed in cancer cells. However, HKII levels and its roles in ATP production and ATP-dependent cellular process have not been well studied in hematopoietic malignant cells including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47829ee754cab4543114c7844ae6f9dd
https://doi.org/10.1007/s10863-012-9412-9
https://doi.org/10.1007/s10863-012-9412-9
Autor:
Keiichiro Watanabe, Kyoko Takeuchi, Qu Cui, Kumiko Kagawa, Hiroe Amou, Ayako Nakano, Shiro Fujii, Takeshi Harada, Asuka Oda, Toshio Matsumoto, Masahiro Abe, Hironobu Shibata, Masahiro Hiasa, Shingen Nakamura, Kenichiro Yata, Shuji Ozaki, Hirokazu Miki
Publikováno v:
International Journal of Hematology. 94:63-70
Multiple myeloma (MM) cells stimulate osteoclastogenesis, and osteoclasts (OCs) in turn enhance MM growth and drug resistance, resulting in a vicious cycle. Vγ9Vδ2 T cells exert potent anti-tumor effects, making T cell-based immunotherapies using t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a739df784fa49afaef72a215bb6371e4
https://doi.org/10.1007/s12185-011-0885-9
https://doi.org/10.1007/s12185-011-0885-9
Autor:
Kyoko Takeuchi, Masahiro Abe, Masahiro Hiasa, Itsuro Endo, Toshio Matsumoto, Akira Sakai, Kenichiro Yata, Shingen Nakamura, Kumiko Kagawa, Asuka Oda, Ayako Nakano, Jin Asano, Hiroe Amou, Shiro Fujii, Takeshi Harada, Shuji Ozaki, Hirokazu Miki
Publikováno v:
Leukemia. 25:1182-1188
Bone marrow stromal cells (BMSCs) and osteoclasts (OCs) confer multiple myeloma (MM) cell survival through elaborating factors. We demonstrate herein that IL-6 and TNF family cytokines, TNFα, BAFF and APRIL, but not IGF-1 cooperatively enhance the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333e8cce64bd8bef7387cc82995325ce
https://doi.org/10.1038/leu.2011.60
https://doi.org/10.1038/leu.2011.60
Autor:
Kumiko Kagawa, Toshio Matsumoto, Kenichiro Yata, Eiji Tanaka, Kenzo Asaoka, Hiroe Amou, Shuji Ozaki, Ayako Nakano, Shinsuke Kido, Keiji Moriyama, Toshihiro Hashimoto, Kyoko Takeuchi, Masahiro Abe, Masahiro Hiasa, Asuka Oda
Publikováno v:
Blood. 114:4517-4526
Monocytes give rise to macrophages, osteoclasts (OCs), and dendritic cells (DCs). Macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappaB (RANK) ligand induce OC differentiation from monocytes, whereas granulocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6dea665724fecb2933af8162d9eb72
https://doi.org/10.1182/blood-2009-04-215020
https://doi.org/10.1182/blood-2009-04-215020
Autor:
Ayako Nakano, Shuji Ozaki, Takeshi Harada, Hiroe Amou, Toshio Matsumoto, Masahiro Abe, Kenichi Kitazoe, Asuka Oda, Toshihiro Hashimoto, Masahiro Hiasa, Kyoko Takeuchi
Publikováno v:
International Journal of Hematology. 89:45-57
Multiple myeloma is still an incurable disease, most commonly occurring in the elderly. The myeloma-induced bone marrow microenvironment protects myeloma cells from drug-induced apoptosis. Therefore, the development of novel and tolerable therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8156494622b48230176389b36c69dfa
https://doi.org/10.1007/s12185-008-0226-9
https://doi.org/10.1007/s12185-008-0226-9