Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Hiroaki Todo"'
Autor:
Daisuke Sasaki, Hinako Suzuki, Kosuke Kusamori, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Rice bran a by-product of the rice milling process is currently underutilized. Recent studies have shown that plant-derived nanoparticles (pdNPs) can be mass-produced at a low cost and exhibit biological and therapeutic activities
Externí odkaz:
https://doaj.org/article/9c1cb045dab54284b2a343c35537cc2a
Autor:
Hiroaki Todo, Rina Niki, Akie Okada, Ibuki Narita, Kazuya Inamura, Ayu Ito, Shoko Itakura, Ichiro Hijikuro, Kenji Sugibayashi
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Non-lamellar liquid crystal (NLLC) structures have gained increasing attention for the controlled release of entrapped drugs. In the present study, an in situ NLLC structure-forming depot formulation through contact with water was developed using a t
Externí odkaz:
https://doaj.org/article/c9c6b2ca48e54baf8776b7e15015be95
Autor:
Shoko Itakura, Ayaka Shohji, Sayaka Amagai, Masashi Kitamura, Kozo Takayama, Kenji Sugibayashi, Hiroaki Todo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Small interfering RNAs (siRNAs) knockdown the expression of target genes by causing mRNA degradation and are a promising therapeutic modality. In clinical practice, lipid nanoparticles (LNPs) are used to deliver RNAs, such as siRNA and mRNA,
Externí odkaz:
https://doaj.org/article/f96df1de8724498eadfc95c6b189c627
Publikováno v:
AAPS Open, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Purpose Nobiletin (NOB), a polymethoxyflavonoid, is known for its antioxidant and anti-inflammatory effects and has antitumor activity. However, its poor solubility and low bioavailability pose a significant challenge in its delivery. In thi
Externí odkaz:
https://doaj.org/article/220498e22fa74a67a6811dc55d0faf84
Autor:
Ayu Ito, Shoko Itakura, Yuya Hasegawa, Miyu Hashimoto, Akie Okada, Mamoru Hirafuji, Hidenori Nakamura, Kenji Sugibayashi, Hiroaki Todo
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Patients receiving chemotherapy by intravenous (i.v.) or oral administration of anticancer drugs often experience side effects. In this study, an electro-osmotic flow (EO) pump was used for the direct administration of an anticancer drug with minimum
Externí odkaz:
https://doaj.org/article/4bb2d619a61945f5bc998ac069e0bd7b
Autor:
Yutaka Inoue, Sae Ueda, Takashi Tanikawa, Aiko Sano, Ryuichiro Suzuki, Hiroaki Todo, Yuji Higuchi, Kenichi Akao
Publikováno v:
Foods, Vol 12, Iss 21, p 4004 (2023)
We investigated the physicochemical properties of Japanese rice wines, including their functional properties and carbohydrate and amino acid content in solution and solid state. Three samples were tested. The glucose, allose, and raffinose contents i
Externí odkaz:
https://doaj.org/article/ddc02555071c40e483b895759888836f
Autor:
Hajime Kojima, Tokio Nakada, Akiko Yagami, Hiroaki Todo, Jihei Nishimura, Mio Yagi, Keiko Yamamoto, Mariko Sugiyama, Yoshiaki Ikarashi, Hitoshi Sakaguchi, Masahiko Yamaguchi, Morihiko Hirota, Sakiko Aizawa, Shota Nakagawa, Shigenobu Hagino, Masato Hatao
Publikováno v:
Current Research in Toxicology, Vol 4, Iss , Pp 100100- (2023)
Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evi
Externí odkaz:
https://doaj.org/article/87dee5b26ae9496ab51c2bcc9ad2ae5d
Autor:
Daisuke Sasaki, Kosuke Kusamori, Yukiya Takayama, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Recent studies showed that plant-derived nanoparticles (NPs) can be easily produced in high yields and have potential applications as therapeutic agents or delivery carriers for bioactive molecules. In this study, we selected corn as it is i
Externí odkaz:
https://doaj.org/article/3ad506f4c34b4dada91c8ee949aefc8f
Autor:
Mitsuhiro Kamimura, Takako Ohnishi, Hisao Terada, Atsuto Mouri, Takahiro Naoi, Hiroaki Todo, Kenji Sugibayashi
Publikováno v:
Iberoamerican Journal of Medicine, Vol 3, Iss 1, Pp 44-50 (2021)
Introduction: Allergic conjunctivitis is treated with oral anti-allergy agents or topical eye drops, but the response is often incomplete, and symptoms persist. We considered that topical treatment with an antihistamine ointment (diphenhydramine-Rest
Externí odkaz:
https://doaj.org/article/ee1ff778b733497bafa191723393707a
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1370 (2022)
Estimation of the percutaneous absorption is essential for the safety assessment of cosmetic and dermopharmaceutical products. Currently, an artificial membrane, Strat-M®, has been focused on as the tool which could obtain the permeation parameters
Externí odkaz:
https://doaj.org/article/0776f89ecfa44cbaa9a85d0df19a6b02