Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Hiroaki Tachiwana"'
Autor:
Yasuhiro Arimura, Hiroaki Tachiwana, Hiroki Takagi, Tetsuya Hori, Hiroshi Kimura, Tatsuo Fukagawa, Hitoshi Kurumizaka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Kinetochore function depends on H4K20 monomethylation in centromeric nucleosomes but the underlying mechanism is unclear. Here, the authors provide evidence that the centromere-specific nucleosome subunit CENP-A facilitates H4K20 methylation by enabl
Externí odkaz:
https://doaj.org/article/b792e5547ea1411d9cc207781efaa5ba
Autor:
Hiroaki Tachiwana, Mariko Dacher, Kazumitsu Maehara, Akihito Harada, Yosuke Seto, Ryohei Katayama, Yasuyuki Ohkawa, Hiroshi Kimura, Hitoshi Kurumizaka, Noriko Saitoh
Publikováno v:
eLife, Vol 10 (2021)
In eukaryotes, histone variant distribution within the genome is the key epigenetic feature. To understand how each histone variant is targeted to the genome, we developed a new method, the RhIP (Reconstituted histone complex Incorporation into chrom
Externí odkaz:
https://doaj.org/article/f97aed3f27f54c5daf06296f3a740c15
Autor:
Jun Ueda, Akihito Harada, Takashi Urahama, Shinichi Machida, Kazumitsu Maehara, Masashi Hada, Yoshinori Makino, Jumpei Nogami, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroki Tanaka, Hiroaki Tachiwana, Tatsuma Yao, Minami Yamada, Takashi Iwamoto, Ayako Isotani, Masahito Ikawa, Taro Tachibana, Yuki Okada, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Kazuo Yamagata
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 593-600 (2017)
Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early
Externí odkaz:
https://doaj.org/article/06d1e957ec7a424ab096f2a87b360b82
Autor:
Hiroaki Tachiwana, Sebastian Müller, Julia Blümer, Kerstin Klare, Andrea Musacchio, Geneviève Almouzni
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 22-32 (2015)
Although our understanding of centromere maintenance, marked by the histone H3 variant CenH3CENP-A in most eukaryotes, has progressed, the mechanism underlying the de novo formation of centromeres remains unclear. We used a synthetic system to dissec
Externí odkaz:
https://doaj.org/article/7f9bedd064124239a96f099731d0a9ec
Autor:
Wakana Iwasaki, Yuta Miya, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroaki Tachiwana, Takehiko Shibata, Wataru Kagawa, Hitoshi Kurumizaka
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1567-1567 (2018)
Externí odkaz:
https://doaj.org/article/e09dd384e2c74ed988b10cd7865d4932
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120635 (2015)
The dynamics of nucleosomes containing either canonical H3 or its centromere-specific variant CENP-A were investigated using molecular dynamics simulations. The simulations showed that the histone cores were structurally stable during simulation peri
Externí odkaz:
https://doaj.org/article/f32031b9e8014afdbbbb25913a79757a
Autor:
Akihisa Osakabe, Yuichiro Takahashi, Hirokazu Murakami, Kenji Otawa, Hiroaki Tachiwana, Yukako Oma, Hitoshi Nishijima, Kei-ich Shibahara, Hitoshi Kurumizaka, Masahiko Harata
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108354 (2014)
Actin and actin-related proteins (Arps), which are members of the actin family, are essential components of many of these remodeling complexes. Actin, Arp4, Arp5, and Arp8 are found to be evolutionarily conserved components of the INO80 chromatin rem
Externí odkaz:
https://doaj.org/article/ebbb0ae720fd44b98e714bedae0b0269
Autor:
Yukihito Ishizaka, Hitoshi Kurumizaka, Tetsutaro Sata, Yoshimasa Takizawa, Kenzo Tokunaga, Chikako Nakai-Murakami, Mari Shimura, Hiroaki Tachiwana
Recent observations imply that HIV-1 infection induces chromosomal DNA damage responses. However, the precise molecular mechanism and biological relevance are not fully understood. Here, we report that HIV-1 infection causes double-strand breaks in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87e7679ff69dbdadca9d071180babd8
https://doi.org/10.1158/0008-5472.c.6494105
https://doi.org/10.1158/0008-5472.c.6494105
Autor:
Yukihito Ishizaka, Hitoshi Kurumizaka, Tetsutaro Sata, Yoshimasa Takizawa, Kenzo Tokunaga, Chikako Nakai-Murakami, Mari Shimura, Hiroaki Tachiwana
Supplementary Method from HIV-1 Vpr Induces DNA Double-Strand Breaks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5ab8b4e565cc32226e7f5d7ee20518
https://doi.org/10.1158/0008-5472.22364255
https://doi.org/10.1158/0008-5472.22364255
Autor:
Hitoshi Kurumizaka, Shoko Sato, Indu Patwal, Mariko Dacher, Hiroaki Tachiwana, Yukari Iikura, Yoshimasa Takizawa, Fumika Hoshikawa, Naruhiko Adachi, Hiroki Tanaka, Andrew Flaus, C.-H. Ho, Tomoya Kujirai
Publikováno v:
Nucleic Acids Research
Giardia lamblia is a pathogenic unicellular eukaryotic parasite that causes giardiasis. Its genome encodes the canonical histones H2A, H2B, H3, and H4, which share low amino acid sequence identity with their human orthologues. We determined the struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4107261fcc850330c13316ce9460dd8
http://europepmc.org/articles/PMC8421212
http://europepmc.org/articles/PMC8421212