Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hiroaki Segawa"'
Autor:
Kei Suzuki, Hiroyuki Tsunoda, Ryusuke Omiya, Kyoko Matoba, Takeshi Baba, Sachiyo Suzuki, Hiroaki Segawa, Atsushi Kumanogoh, Kenji Iwasaki, Kunihiro Hattori, Junichi Takagi
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156719 (2016)
Semaphorin family proteins act on cells to mediate both repulsive and attractive guidance via binding to plexin family receptors, thereby playing fundamental roles in the morphogenesis and homeostasis of various tissues. Although semaphorin-plexin si
Externí odkaz:
https://doaj.org/article/2e0d38caa8bf4da399a0005b1372ceec
Autor:
Takahisa Kawaguchi, Kazuya Setoh, Yasuharu Tabara, Mikihiro Yamanaka, Shinji Kosugi, Fumihiko Matsuda, Hiroaki Segawa, Takeo Nakayama
Publikováno v:
Journal of Alzheimer's Disease. 74:741-746
Accumulation of advanced glycation end products (AGEs) has been linked with cognitive decline as a risk factor based on the analysis in small populations. We investigated the association between skin autofluorescence of AGEs and global cognitive func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce6fbef2d5c819b5d5ddd0a3070f096
https://doi.org/10.3233/jad-190878
https://doi.org/10.3233/jad-190878
Autor:
Shinji Kosugi, Yasuharu Tabara, Kazuya Setoh, Hiroaki Segawa, Noriaki Ichihashi, Takeo Nakayama, Fumihiko Matsuda, Tome Ikezoe, Tadao Tsuboyama, Mikihiro Yamanaka, Takahisa Kawaguchi
Publikováno v:
The Journals of Gerontology: Series A. 74:1446-1453
Background The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods This study investigated a ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39c1ceeef94148cb5634901a5906168
https://doi.org/10.1093/gerona/gly233
https://doi.org/10.1093/gerona/gly233
Autor:
Yuji Sano, Taichi Kuramochi, Hirotake Shiraiwa, Jun-ichi Nezu, Yosuke Ikeda, Yoko Kayukawa, Hiroko Konishi, Mika Kamata-Sakurai, Naoka Hironiwa, Akihisa Sakamoto, Tetsuya Wakabayashi, Mika Endo, Takahiro Ishiguro, Tomoyuki Igawa, Mizuho Noguchi, Takashi Tsushima, Kunihiro Hattori, Hiroaki Segawa, Toshiaki Tsunenari, Atsushi Narita
Publikováno v:
Methods (San Diego, Calif.). 154
The antibody drug market is rapidly expanding, and various antibody engineering technologies are being developed to create antibodies that can provide better benefit to patients. Although bispecific antibody drugs have been researched for more than 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b5c7c9901f0e6b65736db76ee2071c
https://pubmed.ncbi.nlm.nih.gov/30326272
https://pubmed.ncbi.nlm.nih.gov/30326272
Autor:
Tomoyuki Igawa, Hiroko Konishi, Shuichi Chiba, Yukari Nishito, Etsuko Fujii, Hiroaki Segawa, Toshiaki Tsunenari, Atsushi Narita, Asako Harada, Takashi Tsushima, Hirotake Shiraiwa, Kunihiro Hattori, Eitaro Nanba, Ehab Elgabry, Akihisa Kaneko, Mizuho Noguchi, Lorraine Stewart, Masahiro Aoki, Mika Endo, Hironori Mutoh, Yuji Sano, Jun-ichi Nezu, Yukiko Sonobe, Yoshiki Kawabe, Yumiko Azuma, Shun-ichiro Komatsu, Tetsuya Wakabayashi, Akihisa Sakamoto, Natsuki Ono, Yoko Kayukawa, Kiyoaki Sakata, Yasuko Kinoshita, Yoko Miyazaki, Toshihiko Fujii, Masaki Ishigai, Mika Kamata-Sakurai, Mina Takahashi, Takahiro Ishiguro, Werner Frings
Publikováno v:
Science translational medicine. 9(410)
Cancer care is being revolutionized by immunotherapies such as immune checkpoint inhibitors, engineered T cell transfer, and cell vaccines. The bispecific T cell-redirecting antibody (TRAB) is one such promising immunotherapy, which can redirect T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d23ef2e133f7bf3257b30ef5449c80b
https://pubmed.ncbi.nlm.nih.gov/29147028
https://pubmed.ncbi.nlm.nih.gov/29147028
Autor:
Masayuki Sano, Teruhide Yamaguchi, Hideyuki Sato, Hiromitsu Nakauchi, Mahito Nakanishi, Hiroaki Segawa, Yuzuru Ikehara, Yoko Umemura, Satoko Takayasu, Birei Furuta, Makoto Asashima, Ken Nishimura, Manami Ohtaka, Toshie Kanayasu-Toyoda, Kaori Motomura, Yoshiro Nakajima, Toshihiro Kobayashi, Eriko Uchida
Publikováno v:
Journal of Biological Chemistry. 286:4760-4771
The ectopic expression of transcription factors can reprogram differentiated tissue cells into induced pluripotent stem cells. However, this is a slow and inefficient process, depending on the simultaneous delivery of multiple genes encoding essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdcc525192148416b43d924d8beb2ec6
https://doi.org/10.1074/jbc.m110.183780
https://doi.org/10.1074/jbc.m110.183780
Autor:
Yafeng Zhu, Mamoru Hasegawa, Hiroaki Segawa, Kaoru Takizawa, Hideharu Taira, Tetsuro Yamashita, Masao Miyazaki
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 74:2293-2298
Sendai virus (SeV) is an enveloped virus with a non-segmented negative-strand RNA genome. SeV envelope fusion (F) glycoproteins play crucial roles in the viral life cycle in processes such as viral binding, assembly, and budding. In this study, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36d2ff9ba1dd295ead3e660c7e798a6
https://doi.org/10.1271/bbb.100511
https://doi.org/10.1271/bbb.100511
Autor:
Kozo Takayama, Hiroaki Segawa, Tetsuya Yoshida, Mariko Morishita, Mahito Nakanishi, Ken Nishimura, Hitoshi Takahashi, Masahiro Asada, Akinori Masago, Takahiro Goto, Toru Imamura, Takemasa Sakaguchi, Kunitada Shimotono, Yoshihiro Ohmiya
Publikováno v:
Journal of Biological Chemistry. 282:27383-27391
Persistent and stable expression of foreign genes has been achieved in mammalian cells by integrating the genes into the host chromosomes. However, this approach has several shortcomings in practical applications. For example, large scale production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6ee3883d0ad438f87260fc8d541600
https://doi.org/10.1074/jbc.m702028200
https://doi.org/10.1074/jbc.m702028200
Autor:
Salvatore J. Turco, Masao Kawakita, Stephen M. Beverley, Hiroaki Segawa, Rodrigo Pedro Soares
Publikováno v:
Journal of Biological Chemistry. 280:2028-2035
Activated nucleotide sugars required for the synthesis of glycoconjugates within the secretory pathway of eukaryotes are provided by the action of nucleotide sugar transporters (NSTs). Typically, NSTs are studied in microsomal preparations from wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429454e1388d8d9aa5447cc2a498927b
https://doi.org/10.1074/jbc.m404915200
https://doi.org/10.1074/jbc.m404915200
Publikováno v:
Infection and Immunity. 72:3622-3627
Different Leishmania species rely to different extents on abundant glycoconjugates, such as lipophosphoglycan (LPG) and related molecules, in mammalian infections. Previously, we showed that Leishmania major deletion mutants lacking the Golgi GDP-man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342e91a18715ba04a7d96e3bc4b6f98e
https://doi.org/10.1128/iai.72.6.3622-3627.2004
https://doi.org/10.1128/iai.72.6.3622-3627.2004