Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hiroaki Oyama"'
Autor:
Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama
Publikováno v:
Viruses, Vol 16, Iss 4, p 585 (2024)
The higher-order structure (HOS) is a critical quality attribute of recombinant adeno-associated viruses (rAAVs). Evaluating the HOS of the entire rAAV capsid is challenging because of the flexibility and/or less folded nature of the VP1 unique (VP1u
Externí odkaz:
https://doaj.org/article/4f0dadd2c7e44ce585495c7697d86bf6
Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody
Autor:
Akira Shiota, Takashi Tadokoro, Hiroaki Oyama, Hiroki Koga, Katsumi Maenaka, Masanori Noda, Susumu Uchiyama, Tetsuo Torisu, Masami Yokoyama
Publikováno v:
Journal of Pharmaceutical Sciences. 109:308-315
Aggregation of therapeutic monoclonal antibodies has a potential risk of immunogenicity, requiring minimization of aggregate formation. We have developed a fitting formula for antibody aggregation at 40°C based on physicochemical parameters, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb19ee6c4fb43cdd23dea5c146095bc9
https://doi.org/10.1016/j.xphs.2019.10.038
https://doi.org/10.1016/j.xphs.2019.10.038
Autor:
Tetsuo Torisu, Susumu Uchiyama, Kentaro Ishii, Takashi Tadokoro, Hiroaki Oyama, Katsumi Maenaka, Masanori Noda, Mika Yamauchi
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2323-2333
Antibody aggregates are a potential risk for immunogenicity; therefore, rational approaches to improve associated aggregation properties need to be developed. Here, we report the amino acid region responsible for aggregation initiation. Two types of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432f9acd566bd4ca5eff4a8e1255cea2
https://doi.org/10.1016/j.xphs.2019.02.023
https://doi.org/10.1016/j.xphs.2019.02.023
Publikováno v:
Journal of the Mass Spectrometry Society of Japan. 66:218-221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a462cb08821b9488902b5c6f147af2e
https://doi.org/10.5702/massspec.s18-44
https://doi.org/10.5702/massspec.s18-44
Publikováno v:
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C. 66:573-578
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2123ae978a267a3a2b302cf1ec03c585
https://doi.org/10.1299/kikaic.66.573
https://doi.org/10.1299/kikaic.66.573