Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Hiroaki NABEKA"'
Autor:
Sakirul Khan, Akihide Takeuchi, Hiroaki Nabeka, Farzana Khan, Tetsuya Shimokawa, Sota Takanezawa, Takashi Saitou, Takeshi Imamura, Tetsuya Tachibana, Akira Nishizono, Fumihiko Hamada, Seiji Matsuda
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106277- (2023)
Summary: Neural tube defects (NTDs) cause fetal and pediatric deaths or lifelong neurological disabilities. No effective treatment is currently available for NTDs. We attempted to elucidate the pathogenesis of NTDs and propose a therapeutic strategy.
Externí odkaz:
https://doaj.org/article/128380307a99435e8ad3e3918d24e6fe
Autor:
Md. Sarikul Khan, Hiroaki Nabeka, Farzana Islam, Tetsuya Shimokawa, Shouichiro Saito, Tetsuya Tachibana, Seiji Matsuda
Publikováno v:
Folia Neuropathologica, Vol 58, Iss 2, Pp 151-165 (2020)
Spina bifida aperta (SBA), one of the most common congenital malformations, causes various neurological disorders. Pain is a common complaint of patients with SBA. However, little is known about the neuropathology of SBA-related pain. Because loss of
Externí odkaz:
https://doaj.org/article/f3179472f7484e3a8f6b723afabd8389
Autor:
Miho Taniguchi, Hiroaki Nabeka, Kimiko Yamamiya, Md. Sakirul Islam Khan, Tetsuya Shimokawa, Farzana Islam, Takuya Doihara, Hiroyuki Wakisaka, Naoto Kobayashi, Fumihiko Hamada, Seiji Matsuda
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor, as well as a regulator of lysosomal enzymes. Recently, the orphan G-protein-coupled receptors GPR
Externí odkaz:
https://doaj.org/article/20ef7b8059134570aa9251289a0ad181
Autor:
Md. Sakirul Islam Khan, Hiroaki Nabeka, Farzana Islam, Tetsuya Shimokawa, Shouichiro Saito, Xuan Li, Soichiro Kawabe, Fumihiko Hamada, Tetsuya Tachibana, Seiji Matsuda
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1421-1432 (2017)
Spina bifida aperta (SBA), one of the most common congenital malformations, causes lifelong neurological complications, particularly in terms of motor dysfunction. Fetuses with SBA exhibit voluntary leg movements in utero and during early neonatal li
Externí odkaz:
https://doaj.org/article/ba42dc8c321f4ad3afa6d3f7c05f30b8
Autor:
Hiroaki Nabeka, Shouichiro Saito, Xuan Li, Tetsuya Shimokawa, Md. Sakirul Islam Khan, Kimiko Yamamiya, Soichiro Kawabe, Takuya Doihara, Fumihiko Hamada, Naoto Kobayashi, Seiji Matsuda
Publikováno v:
IBRO Reports, Vol 3, Iss C, Pp 17-32 (2017)
Prosaposin (PS) is a secretory neurotrophic factor, as well as a regulator of lysosomal enzymes. We previously reported the up-regulation of PS and the possibility of its axonal transport by GABAergic interneurons after exocitotoxicity induced by kai
Externí odkaz:
https://doaj.org/article/dca0b656cfbd4cde9465e2f69ace2202
Autor:
Xuan Li, Hiroaki Nabeka, Shouichiro Saito, Tetsuya Shimokawa, Md. Sakirul Islam Khan, Kimiko Yamamiya, Fengping Shan, Huiling Gao, Cheng Li, Seiji Matsuda
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 31-40 (2017)
Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor that induces differentiation and prevents death in a variety of neuronal cells through the active
Externí odkaz:
https://doaj.org/article/92ff811eb3d143c58d6dc842476d485f
Autor:
Joji Kunihiro, Hiroaki Nabeka, Hiroyuki Wakisaka, Kana Unuma, Md Sakirul Islam Khan, Tetsuya Shimokawa, Farzana Islam, Takuya Doihara, Kimiko Yamamiya, Shouichiro Saito, Fumihiko Hamada, Seiji Matsuda
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0241315 (2020)
Neurotrophic factor prosaposin (PS) is a precursor for saposins A, B, C, and D, which are activators for specific sphingolipid hydrolases in lysosomes. Both saposins and PS are widely contained in various tissues. The brain, skeletal muscle, and hear
Externí odkaz:
https://doaj.org/article/40d0edceabf2430981d08681f2bf6ae1
Autor:
Hiroaki Nabeka, Tetsuya Shimokawa, Takuya Doihara, Shouichiro Saito, Hiroyuki Wakisaka, Fumihiko Hamada, Naoto Kobayashi, Seiji Matsuda
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126856 (2015)
Four sphingolipid activator proteins (i.e., saposins A-D) are synthesized from a single precursor protein, prosaposin (PS), which exerts exogenous neurotrophic effects in vivo and in vitro. Kainic acid (KA) injection in rodents is a good model in whi
Externí odkaz:
https://doaj.org/article/b5c62fd53faa45188bba83f591246ac7
Autor:
Hiroaki Nabeka, Keigo Uematsu, Hiroko Takechi, Tetsuya Shimokawa, Kimiko Yamamiya, Cheng Li, Takuya Doihara, Shouichiro Saito, Naoto Kobayashi, Seiji Matsuda
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e110534 (2014)
Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously
Externí odkaz:
https://doaj.org/article/473ca402665b415a8b2109e4829aede6
Autor:
Midori Morishita, Hiroaki Nabeka, Tetsuya Shimokawa, Kyojy Miyawaki, Takuya Doihara, Shouichiro Saito, Naoto Kobayashi, Seiji Matsuda
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95883 (2014)
Neurogenesis in the hippocampal dentate gyrus occurs constitutively throughout postnatal life. Adult neurogenesis includes a multistep process that ends with the formation of a postmitotic and functionally integrated new neuron. During adult neurogen
Externí odkaz:
https://doaj.org/article/1f288d67b3db4a0793f0ca28c2b3b9f2