Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hiroaki Matsumae"'
Autor:
Masahiro Kyuhara, Isao Inoue, Noriaki Moriyama, Yasunori Moritani, Atsushi Moroda, Takafumi Yamagami, Hiroaki Matsumae, Takeshi Uemura
Publikováno v:
Organic Process Research & Development. 18:437-445
Process research and development for a synthesis of the chiral carboxylic acid (R)-2 as a key intermediate of the glucokinase activator (R)-1 is described. The construction of the stereocenter at the α-carbon is a key point for the synthesis of (R)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfd14fa6ff241f90e3bd715084df0bb6
https://doi.org/10.1021/op400354g
https://doi.org/10.1021/op400354g
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 10:141-149
A lipase from Serratia marcescens was selected as an asymmetric hydrolytic enzyme for trans-3-(4-methoxyphenyl)glycidic acid methyl ester [(±)-MPGM], a key intermediate in the synthesis of diltiazem hydrochloride that is useful as a coronary vasodil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a214c1e842d33c436cb0259cace58d6c
https://doi.org/10.1016/s1381-1177(00)00122-3
https://doi.org/10.1016/s1381-1177(00)00122-3
Publikováno v:
Journal of Fermentation and Bioengineering. 84:195-199
Bakers' yeast-mediated reduction of (RS)-2-(4-methoxyphenyl)-1,5-benzothiazepin-3,4(2H,5H)-dione [(RS)-1] to (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzo-thiazepin-4(5H)-one, a key intermediate in the synthesis of diltiazem hydrochlori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc780fd1b551d3efbfd45749573f7ef
https://doi.org/10.1016/s0922-338x(97)82054-5
https://doi.org/10.1016/s0922-338x(97)82054-5
Autor:
Ikuko Machida, Shinichi Yamada, Takeji Shibatani, Yasuhiko Ozaki, Takuo Noshida, Hiroaki Matsumae
Publikováno v:
Journal of Fermentation and Bioengineering. 81:534-537
Microbial production of (2 S ,3 S )-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5 H )-one [(2 S ,3 S )-DHMB], a key intermediate in the synthesis of diltiazem hydrochloride, was investigated. In the course of the screening of micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6363fd3ba07ef502baa2afc3483c76c3
https://doi.org/10.1016/0922-338x(96)81475-9
https://doi.org/10.1016/0922-338x(96)81475-9
Publikováno v:
Biocatalysis and Biotransformation. 12:205-214
As a result of screening of microorganisms, Mucor ambiguus IFO 6742 was found to reduce methyl 2-chloro-3-(4-methoxyphenyl)-3-oxopropionate (2) to give methyl (2S,3R)-2-chloro-3-hydroxy-3-(4-methox...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::834614fe02f188aea3552d06c16be29e
https://doi.org/10.3109/10242429508998163
https://doi.org/10.3109/10242429508998163
Autor:
Yasuhiko Ozaki, Takeji Shibatani, Takuo Nishida, Tetsuya Tosa, Hiroshi Douno, Shinichi Yamada, Hiroaki Matsumae
Publikováno v:
Journal of Fermentation and Bioengineering. 79:28-32
Microbial production of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one [(2S,3S)-2], a key intermediate in the synthesis of diltiazem hydrochloride, was examined. The reduction of (RS)-2-(4-methoxyphenyl)-1,5-benzothiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1edcde6046c42b44c490f9359a4669df
https://doi.org/10.1016/0922-338x(95)92739-y
https://doi.org/10.1016/0922-338x(95)92739-y
Publikováno v:
Journal of Fermentation and Bioengineering. 78:59-63
(±)- trans -3-(4-Methoxyphenyl)glycidic acid methyl ester [(±)-MPGM], a key intermediate in the synthesis of diltiazem hydrochloride, was efficiently hydrolyzed by lipase from Serratia marcescens Sr41 8000 immobilized on a hollow-fiber ultrafiltrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34c43c27349a472eefcdceab741cf63
https://doi.org/10.1016/0922-338x(94)90179-1
https://doi.org/10.1016/0922-338x(94)90179-1
Autor:
Hiroaki Matsumae, Takeji Shibatani
Publikováno v:
Journal of Fermentation and Bioengineering. 77:152-158
A new lipase which enantioselectively hydrolyzes (±)- trans -3-(4-methoxyphenyl)glycidic acid methyl ester [(±)-MPGM], a key intermediate in the synthesis of diltiazem hydrochloride, was purified from the culture supernatant of Serratia marcescens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf4c1f305b8e1c97e5fae88e6544b362
https://doi.org/10.1016/0922-338x(94)90315-8
https://doi.org/10.1016/0922-338x(94)90315-8
Publikováno v:
Journal of Fermentation and Bioengineering. 75:93-98
Asymmetric hydrolytic enzymes for trans -3-(4-methoxyphenyl)glycidic acid methyl ester [(±)-MPGM], a key intermediate in the synthesis of diltiazem hydrochloride that is useful as a coronary vasodilator, were screened from 730 microorganisms. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8fb25679137b4b660d28fdd65cc3b5
https://doi.org/10.1016/0922-338x(93)90216-u
https://doi.org/10.1016/0922-338x(93)90216-u
