Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Hiroaki Iwasa"'
Autor:
Yuxiong Lu, Junichi Maruyama, Keiko Kuwata, Hiroyuki Fukuda, Hiroaki Iwasa, Kyoko Arimoto-Matsuzaki, Haruhiko Sugimura, Yutaka Hata
Publikováno v:
Biochemistry and Biophysics Reports, Vol 16, Iss , Pp 130-137 (2018)
Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer stem cells a
Externí odkaz:
https://doaj.org/article/005344664f7942b2a026956de9624252
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4478 (2022)
Pancreatic β-cells are specialized to properly regulate blood glucose. Maintenance of the mature β-cell phenotype is critical for glucose metabolism, and β-cell failure results in diabetes mellitus. Recent studies provide strong evidence that the
Externí odkaz:
https://doaj.org/article/bb22ce2ccd2a4f2d993869ac0c01fa27
Autor:
Yutaka Hata, Kouhei Yamamoto, Daichi Nogawa, Hiroshi Nishina, Jun Hirayama, Norio Miyamura, Hiroyuki Kagechika, Mari Ishigami-Yuasa, Kentaro Nakagawa, Hiroaki Iwasa, Xinliang Jiang, Fumiyoshi Michishita, Kazutoshi Inami, Junichi Maruyama
Yes-associated protein 1 (YAP1) interacts with numerous transcription factors, including TEA-domain family proteins (TEAD) and p73. YAP1 is negatively regulated by the tumor suppressor Hippo pathway. In human cancers, the deregulation of the Hippo pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0629eb868bc6c4f437c0cddfc760299c
https://doi.org/10.1158/1541-7786.c.6540226.v1
https://doi.org/10.1158/1541-7786.c.6540226.v1
Autor:
Yutaka Hata, Kouhei Yamamoto, Daichi Nogawa, Hiroshi Nishina, Jun Hirayama, Norio Miyamura, Hiroyuki Kagechika, Mari Ishigami-Yuasa, Kentaro Nakagawa, Hiroaki Iwasa, Xinliang Jiang, Fumiyoshi Michishita, Kazutoshi Inami, Junichi Maruyama
Supplementary Figures 1 - 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72be4d602f157f388087384329931d98
https://doi.org/10.1158/1541-7786.22512376
https://doi.org/10.1158/1541-7786.22512376
Autor:
Caleb Kwame Sinclear, Junichi Maruyama, Shunta Nagashima, Kyoko Arimoto‐Matsuzaki, Joshua Agbemefa Kuleape, Hiroaki Iwasa, Hiroshi Nishina, Yutaka Hata
Publikováno v:
Cancer Science. 113:1305-1320
Yes-associated protein 1 (YAP1) interacts with TEAD transcription factor in the nucleus and upregulates TEAD-target genes. YAP1 is phosphorylated by large tumor suppressor (LATS) kinases, the core kinases of the Hippo pathway, at 5 serine residues an
Autor:
Yutaka Hata, Masanobu Kitagawa, Mayu Morishita, Yuichi Hiraoka, Kohei Yamamoto, Kyohei Niimura, Masami Kitamura, Hiroaki Iwasa, Hiroshi Nishina, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Norio Miyamura
Publikováno v:
Genes to Cells. 26:999-1013
RASSF6 is a member of the tumor suppressor Ras-association domain family (RASSF) proteins. We have reported using human cancer cell lines that RASSF6 induces apoptosis and cell cycle arrest via p53 and plays tumor-suppressive roles. In this study, we
Autor:
Joshua Agbemefa Kuleape, Shakhawoat Hossain, Caleb Kwame Sinclear, Takanobu Shimizu, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata
Publikováno v:
Mol Cell Biol
RASSF6, a member of the tumor suppressor Ras-association domain family (RASSF) proteins, regulates cell cycle arrest and apoptosis via p53 and plays a tumor suppressor role. We previously reported that RASSF6 blocks MDM2-mediated p53 degradation and
Autor:
Kyoko Arimoto-Matsuzaki, Takanobu Shimizu, Takao Nakata, Hiroshi Nishina, Yutaka Hata, Hiroaki Iwasa, Takeshi Nakamura, Junichi Maruyama, Hironori Inaba
Publikováno v:
J Biol Chem
The gene encoding the proto-oncogene GTPase RAS is frequently mutated in human cancers. Mutated RAS proteins trigger antiapoptotic and cell-proliferative signals and lead to oncogenesis. However, RAS also induces apoptosis and senescence, which may c
Autor:
Hiroyuki Kagi, Surabhi Sudevan, Masayoshi Nishiyama, Atsushi Higashitani, Ayano Fujita, Yutaka Hata, Masaru Watanabe, Keiji Naruse, Masatoshi Morimatsu, Hiroaki Iwasa, Naoshi Watanabe, Mika Teranishi
Publikováno v:
Biochemical and Biophysical Research Communications. 523:853-858
Mechanical stimulation is well known to be important for maintaining tissue and organ homeostasis. Here, we found that hydrostatic pressure induced nuclear translocation of a forkhead box O (FOXO) transcription factor DAF-16, in C. elegans within min
Autor:
Yutaka Hata, Junichi Maruyama, Haruhiko Sugimura, Hiroaki Iwasa, Yuxiong Lu, Kyoko Arimoto-Matsuzaki, Keiko Kuwata, Hiroyuki Fukuda
Publikováno v:
Biochemistry and Biophysics Reports. 16:130-137
Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer stem cells a