Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Hiroaki Haga"'
Autor:
Tomohiro Katsumi, Hidenori Sato, Ryoko Murakami, Takumi Hanatani, Fumi Uchiyama, Fumiya Suzuki, Keita Maki, Kyoko Hoshikawa, Hiroaki Haga, Takafumi Saito, Yoshiyuki Ueno
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0308912 (2024)
BackgroundMultiple factors are involved in the pathogenesis of primary biliary cholangitis (PBC), a chronic cholestatic liver disease, characterized by intrahepatic cholangiopathy. In particular, studies have suggested that environmental factors such
Externí odkaz:
https://doaj.org/article/b75ebaf954d44ae6b3cce53f5fd10a35
Autor:
Shinpei Sugahara, Hiroaki Haga, Chisaki Ikeda, Naohiko Makino, Akiko Matsuda, Yasuharu Kakizaki, Kyoko Hoshikawa, Tomohiro Katsumi, Tetsuya Ishizawa, Toshikazu Kobayashi, Keita Maki, Fumiya Suzuki, Ryoko Murakami, Hidenori Sato, Yoshiyuki Ueno
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9230 (2023)
Although liver regeneration has been extensively studied, the effects of bile-derived extracellular vesicles (bile EVs) on hepatocytes has not been elucidated. We examined the influence of bile EVs, collected from a rat model of 70% partial hepatecto
Externí odkaz:
https://doaj.org/article/98ec24572fbd4136aa67a0d4f269c80d
Autor:
Chisaki Ikeda, Hiroaki Haga, Naohiko Makino, Tatsutoshi Inuzuka, Ayako Kurimoto, Toshiki Ueda, Akiko Matsuda, Yasuharu Kakizaki, Tetsuya Ishizawa, Toshikazu Kobayashi, Shinpei Sugahara, Michihiko Tsunoda, Kensei Suda, Yoshiyuki Ueno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Extracellular vesicles (EVs) are released from all cells. Bile directly contacts bile duct tumor; bile-derived EVs may contain high concentrations of cancer biomarkers. We performed a proteomic analysis of human bile-derived EVs and identifi
Externí odkaz:
https://doaj.org/article/2119de3100cd44909ab068f6c9eef018
Autor:
Kei Mizuno, Hiroaki Haga, Kazuo Okumoto, Kyoko Hoshikawa, Tomohiro Katsumi, Taketo Nishina, Takafumi Saito, Hideki Katagiri, Yoshiyuki Ueno
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249556 (2021)
Autonomic nerve fibers in the liver are distributed along the portal tract, being involved in the regulation of blood flow, bile secretion and hepatic metabolism, thus contributing to systemic homeostasis. The present study investigated changes in he
Externí odkaz:
https://doaj.org/article/9fa509e0ad9c4756b83929ef2215a55e
Autor:
Hiroaki Haga, Hidenori Sato, Ayumi Koseki, Takafumi Saito, Kazuo Okumoto, Kyoko Hoshikawa, Tomohiro Katsumi, Kei Mizuno, Taketo Nishina, Yoshiyuki Ueno
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242028 (2020)
In recent years, the development of diagnostics using artificial intelligence (AI) has been remarkable. AI algorithms can go beyond human reasoning and build diagnostic models from a number of complex combinations. Using next-generation sequencing te
Externí odkaz:
https://doaj.org/article/469b2ea1fd3940dba348d7f2794db829
Publikováno v:
Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-13 (2015)
The contributions of mesenchymal stem cells (MSCs) to tumour growth and stroma formation are poorly understood. Tumour cells can transfer genetic information and modulate cell signalling in other cells through the release of extracellular vesicles (E
Externí odkaz:
https://doaj.org/article/12b2f0ea90344e5db9dcc919b1b93796
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 458-467 (2014)
Hepatocellular cancers (HCC) are highly resistant to chemotherapy. TGFβ has been associated with chemoresistance in some human cancers but the mechanisms involved are unknown. We explored how TGFβ might contribute to altered responses to therapy by
Externí odkaz:
https://doaj.org/article/f2baa81f9965441eb2ef2f9c8766101e
Autor:
Kiyoshi Hayasaka, Chikahiko Numakura, Kentaro Toyota, Satoru Kakizaki, Hisayoshi Watanabe, Hiroaki Haga, Hiroshi Takahashi, Yoshimi Takahashi, Mieko Kaneko, Mitsunori Yamakawa, Hiroyuki Nunoi, Takeo Kato, Yoshiyuki Ueno, Masatomo Mori
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 1, Iss C, Pp 42-50 (2014)
Background: Citrin, encoded by SLC25A13, is a component of the malate-aspartate shuttle, which is the main NADH-transporting system in the liver. Citrin deficiency causes neonatal intrahepatic cholestasis (NICCD), which usually resolves within the fi
Externí odkaz:
https://doaj.org/article/770744e4e35944e69abc7f06ff045e47
Autor:
Junitsu Ito, Takafumi Saito, Chikahiko Numakura, Akiko Iwaba, Shinpei Sugahara, Rika Ishii, Chikako Sato, Hiroaki Haga, Kazuo Okumoto, Yuko Nishise, Hisayoshi Watanabe, Hiroyuki Ida, Kiyoshi Hayasaka, Hitoshi Togashi, Sumio Kawata, Yoshiyuki Ueno
Publikováno v:
Case Reports in Gastroenterology, Vol 7, Iss 2, Pp 340-346 (2013)
A 21-year-old man with a history of sudden rectal hemorrhage was referred to our hospital. Examination disclosed thrombocytopenia and hepatosplenomegaly. A liver biopsy specimen demonstrated Gaucher cells in Glisson's capsule. Additional investigatio
Externí odkaz:
https://doaj.org/article/b3458815459a476abee56212f39e5130
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0155888 (2016)
Although a key determinant of hepatic recovery after injury is active liver regeneration, the ability to detect ongoing regeneration is lacking. The restoration of liver mass after hepatectomy involves systemic changes with coordinated changes in gen
Externí odkaz:
https://doaj.org/article/c83b0f76ac4c41bbb795d0e4ec7149fe