Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Hiroaki Gouda"'
Autor:
Akihiro Nakamura, Yoshiyuki Suzuki, Yasumitsu Sakamoto, Saori Roppongi, Chisato Kushibiki, Natsuri Yonezawa, Masato Takahashi, Yosuke Shida, Hiroaki Gouda, Takamasa Nonaka, Nobutada Tanaka, Wataru Ogasawara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The emergence of drug-resistant bacteria has become a major problem worldwide. Bacterial dipeptidyl peptidases 7 and 11 (DPP7s and DPP11s), belonging to the family-S46 peptidases, are important enzymes for bacterial growth and are not presen
Externí odkaz:
https://doaj.org/article/b6c00e65e97349549b97e2a4e38cc085
Autor:
Chiharu Iwamatsu, Daichi Hayakawa, Tomomi Kono, Ayaka Honjo, Saki Ishizaki, Shigeto Hirayama, Hiroaki Gouda, Hideaki Fujii
Publikováno v:
Molecules, Vol 25, Iss 17, p 3792 (2020)
We have recently reported that N-alkyl and N-acyl naltrindole (NTI) derivatives showed activities for the δ opioid receptor (DOR) ranging widely from full inverse agonists to full agonists. We newly designed sulfonamide-type NTI derivatives in order
Externí odkaz:
https://doaj.org/article/a86587e5a06c412c82bbc9af530502ee
Autor:
Michiko Jo, Keiichi Koizumi, Mizuho Suzuki, Daisuke Kanayama, Yurie Watanabe, Hiroaki Gouda, Hisashi Mori, Mineyuki Mizuguchi, Takayuki Obita, Yuko Nabeshima, Naoki Toyooka, Takuya Okada
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 87:129266
Autor:
Yuka Uenohara, Saori Tsumura, Shigeto Hirayama, Eika Higashi, Yurie Watanabe, Hiroaki Gouda, Hiroshi Nagase, Hideaki Fujii
Publikováno v:
Bioorganicmedicinal chemistry. 53
The κ opioid receptor (KOR) is one of the promising targets to develop analgesics lacking morphine like side effects. To seek a novel KOR agonist we designed 6-amide derivatives with an oxabicyclo[3.2.1]octane structure based on a proposed active co
Autor:
Noriki Kutsumura, Tsuyoshi Saitoh, Jumpei Horiuchi, Yukiko Ishikawa, Emi Hasegawa, Yasuyuki Nagumo, Masashi Yanagisawa, Takeshi Sakurai, Ryuji Tanimura, Hiroaki Gouda, Naoshi Yamamoto, Yasuhiro Ogawa, Akihisa Tokuda, Tetsu Sato, Yoko Irukayama-Tomobe, Mao Amezawa, Hiroshi Nagase, Ryuichiro Oshita, Yasuo Uchida
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors. We have focused on the 1,3,5-trioxazatriquinane skeleton, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4079393b5fe25c5fc1566ec1c12834a
https://doi.org/10.33774/chemrxiv-2021-08md1
https://doi.org/10.33774/chemrxiv-2021-08md1
Autor:
Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Ohshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Emi Hasegawa, Takeshi Sakurai, Yasuo Uchida, Tetsu Sato, Hiroaki Gouda, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors. We have focused on the 1,3,5-trioxazatriquinane skeleton, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0571529b5d14b8ad54e10a712a84a9
https://doi.org/10.26434/chemrxiv-2021-08md1
https://doi.org/10.26434/chemrxiv-2021-08md1
Publikováno v:
Chemical Physics Letters. 802:139754
Autor:
Chisato Kushibiki, Yasumitsu Sakamoto, Yurie Watanabe, Hitoshi Sakashita, Wataru Ogasawara, Osamu Tani, Yosuke Shida, Koji Inaka, Ippei Iizuka, Hiroaki Gouda, Saori Roppongi, Hiroaki Tanaka, Takamasa Nonaka, Akihiro Nakamura, Mayumi Nakanishi-Matsui, Mitsugu Yamada, Nobutada Tanaka, Mizuki Sekiya, Kazunori Ohta, Yoshiyuki Suzuki, Nobuyuki Honma
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Antimicrobial resistance is a global public threat and raises the need for development of new antibiotics with a novel mode of action. The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs to a new class of serine peptidases, fa
Autor:
Daichi Hayakawa, Noriki Kutsumura, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsuyoshi Saitoh, Naoshi Yamamoto, Takahiro Okada, Hiroaki Gouda, Sayaka Ohrui, Masashi Yanagisawa, Yurie Watanabe, Hiroshi Nagase, Yasuyuki Nagumo, Yasuhiro Ogawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1747-1758
Morphinan derivatives lacking the 4,5-epoxy ring were synthesized to examine the participation of the 14-OH group, the 3-OMe group, and the aromaticity of the A-ring in the activity and selectivity for the orexin 1 receptor (OX1R). The assay results
Autor:
Akihiro Nakamura, Yoshiyuki Suzuki, Wataru Ogasawara, Saori Roppongi, Chisato Kushibiki, Nobutada Tanaka, Hiroaki Gouda, Natsuri Yonezawa, Yosuke Shida, Takamasa Nonaka, Yasumitsu Sakamoto, Masato Takahashi
The emergence of drug-resistant bacteria has become a major problem worldwide. Bacterial dipeptidyl peptidases 7 and 11 (DPP7s and DPP11s), belonging to the family-S46 peptidases, are important enzymes for bacterial growth and are not present in mamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b805c4afc7727b5de4e95c1b5c6a19aa
https://doi.org/10.21203/rs.3.rs-142430/v1
https://doi.org/10.21203/rs.3.rs-142430/v1