Výsledky vyhledávání - "Hiroaki ASANO"

Akademický článek

Transomental hernias: Multi-detector row computed tomography findings in 15 clinical cases

Autor: Tetsunobu Udaka, Takeyoshi Nishiyama, Tomoaki Ohtsuka, Nobuyuki Watanabe, Izuru Endou, Osamu Yoshida, Hiroaki Asano, Masatoshi Kubo, Hironori Kurokawa

Publikováno v: Radiography Open, Vol 8, Iss 1 (2022)

Introduction: Transomental hernia (TOH), a type of intra-abdominal hernia formed as a result of incarceration through abdominal greater omental hiatus, is a rare disease that lacks specific physical features, which makes its preoperative diagnosis di

Externí odkaz: https://doaj.org/article/da15496fea6a4842a1e86f50fa94ef5f

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Akademický článek

A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells

Autor: Keisuke Sumide, Yoshikazu Matsuoka, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Hiroaki Asano, Yoshihiro Takihara, Yoshiaki Sonoda

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haema

Externí odkaz: https://doaj.org/article/c550f20a25a54ac691d698a7862e3926

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Akademický článek

TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells

Autor: Hiroshi Kawamura, Ryusuke Nakatsuka, Yoshikazu Matsuoka, Keisuke Sumide, Tatsuya Fujioka, Hiroaki Asano, Hirokazu Iida, Yoshiaki Sonoda

Publikováno v: Stem Cell Reports, Vol 10, Iss 3, Pp 920-932 (2018)

Summary: It is generally thought that the proliferative capacity and differentiation potential of somatic stem cells, including mesenchymal stromal/stem cells (MSCs) and hematopoietic stem cells, decline with age. We investigated the effects of aging

Externí odkaz: https://doaj.org/article/5f5a7e1da36b46b0ba21b138e76fed2d

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Akademický článek

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer.

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171356 (2017)

Overexpression of human epidermal growth factor receptor 2 (HER2) is observed in approximately 15-23% of breast cancers and these cancers are classified as HER2-positive breast cancer. Trastuzumab is the first-line targeted therapeutic drug for HER2-

Externí odkaz: https://doaj.org/article/5b2dfa564e694a529e34914eeba067c8

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Akademický článek

TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells.

Autor: Hiroki Otani, Hiromasa Yamamoto, Munenori Takaoka, Masakiyo Sakaguchi, Junichi Soh, Masaru Jida, Tsuyoshi Ueno, Takafumi Kubo, Hiroaki Asano, Kazunori Tsukuda, Katsuyuki Kiura, Shinji Hatakeyama, Eiji Kawahara, Yoshio Naomoto, Shinichiro Miyoshi, Shinichi Toyooka

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129838 (2015)

TAE226, a bis-anilino pyrimidine compound, has been developed as an inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor-I receptor (IGF-IR). In this study, we investigated the effect of TAE226 on non-small-cell lung cancer (NSCLC)

Externí odkaz: https://doaj.org/article/6a7d1b9e26b24b4c9a39fa961371116e

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Akademický článek

Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer.

Autor: Kazuhiko Shien, Norimitsu Tanaka, Masami Watanabe, Junichi Soh, Masakiyo Sakaguchi, Keitaro Matsuo, Hiromasa Yamamoto, Masashi Furukawa, Hiroaki Asano, Kazunori Tsukuda, Yasutomo Nasu, Nam-Ho Huh, Shinichiro Miyoshi, Hiromi Kumon, Shinichi Toyooka

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87900 (2014)

REIC/Dkk-3 is down-regulated in a broad range of human cancer cells and is considered to function as a tumor suppressor. We previously reported that REIC/Dkk-3-expressing adenovirus vector (Ad-REIC) induced endoplasmic reticulum (ER) stress and cance

Externí odkaz: https://doaj.org/article/ac58e6e1567d4e58828818b1e6530d1b

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