Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hiroaki, Yamagishi"'
Autor:
Shinya Mimasu, Hiroaki Yamagishi, Satoshi Kubo, Mie Kiyohara, Toshihiro Matsuda, Toshiko Yahata, Heather A. Thomson, Christopher D. Hupp, Julie Liu, Takao Okuda, Kenichi Kakefuda
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Mimasu et al. report a rat full-length structure of kynurenine 3-monooxygenase (KMO) in its membrane-embedded form, complexed with two inhibitors. They find that the dimeric interface of KMO is critical for its activity. This study provides insights
Externí odkaz:
https://doaj.org/article/6e58b6005eed4d88a8484826be69489a
Autor:
Daisuke TAKEUCHI, Masahiro NOZAWA, Hiroaki YAMAGISHI, Yoshimasa UMEHARA, Zhiwei XIAO, Koki NAKAHATA, Ryohei MATSUO, Yushi KAWASAKI, Taisei AOKI, Kohei OUE
Publikováno v:
Japanese Journal of JSCE. 79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b38bc73dfea759ad76c4e32365384834
https://doi.org/10.2208/jscejj.22-22015
https://doi.org/10.2208/jscejj.22-22015
Autor:
Hiroshi Inami, Tsuyoshi Mizutani, Junko Watanabe, Hisashi Hayashida, Tomonori Ito, Takeshi Terasawa, Toru Kontani, Hiroaki Yamagishi, Hiroyuki Usuda, Naohiro Aoyama, Emiko Imamura, Takeshi Ishikawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 87:117302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb34c6f7e0328127015f225e38f84fd4
https://doi.org/10.1016/j.bmc.2023.117302
https://doi.org/10.1016/j.bmc.2023.117302
Autor:
Toshihiro Matsuda, Hiroaki Yamagishi, Mie Kiyohara, Kenichi Kakefuda, Heather A. Thomson, Shinya Mimasu, Satoshi Kubo, Takao Okuda, Toshiko Yahata, Julie Liu, Christopher D. Hupp
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
The structural mechanisms of single-pass transmembrane enzymes remain elusive. Kynurenine 3-monooxygenase (KMO) is a mitochondrial protein involved in the eukaryotic tryptophan catabolic pathway and is linked to various diseases. Here, we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e0363b8e763d8f54667ae97b7f450e
https://pubmed.ncbi.nlm.nih.gov/33542467
https://pubmed.ncbi.nlm.nih.gov/33542467
Autor:
Hiroyuki Usuda, Fumihiro Nakamori, Takayuki Inoue, Hiroaki Tominaga, Yutaka Nakajima, Masamichi Inami, Ayako Moritomo, Misato Ito, Jun Maeda, Takeshi Hondo, Yasuyuki Higashi, Hiroki Morio, Koji Nakamura, Shohei Shirakami, Hiroaki Yamagishi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5311-5326
Janus kinases (JAKs) play a crucial role in cytokine mediated signal transduction. JAK inhibitors have emerged as effective immunomodulative agents for the prevention of transplant rejection. We previously reported that the tricyclic imidazo-pyrrolop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da8d29d1bb301d7f81be2fd50ffa9c1
https://doi.org/10.1016/j.bmc.2017.07.043
https://doi.org/10.1016/j.bmc.2017.07.043
Publikováno v:
Polyhedron. 125:173-178
Octahedral ruthenium(II) complexes bearing a tripodal amine ligand featuring three ionizable pyrazole NH groups, tris((5-mesitylpyrazol-3-yl)methyl)amine (LH3), have been synthesized in a stereoselective manner. Treatment of the chlorido complex [{Ru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c46777a351bb045028d78481ce532b
https://doi.org/10.1016/j.poly.2016.11.037
https://doi.org/10.1016/j.poly.2016.11.037
Publikováno v:
Advances in Embedded and Fan-Out Wafer-Level Packaging Technologies
Today, semiconductor devices with rapidly changing features are the basis for applications that deliver comfort, communication, mobility, environmental, and medical care. New requirements for reliability or environmental constraints are the driving f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e216521903242ebed176055a55de1e9
https://doi.org/10.1002/9781119313991.ch17
https://doi.org/10.1002/9781119313991.ch17
Autor:
Hiroaki Yamagishi, Shohei Shirakami, Akira Tanaka, Masamichi Inami, Takayuki Inoue, Ayako Moritomo, Yutaka Nakajima, Keiko Hatanaka, Fumie Takahashi, Hisao Hamaguchi, Yasuyuki Higashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4846-4859
Because Janus kinases (JAKs) play a crucial role in cytokine-mediated signal transduction, JAKs are an attractive target for the treatment of organ transplant rejection and autoimmune diseases such as rheumatoid arthritis (RA). To identify JAK inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d3665766871cedaef06b4f21305117
https://doi.org/10.1016/j.bmc.2015.05.028
https://doi.org/10.1016/j.bmc.2015.05.028
Autor:
Sakae Toyoda, Shuichi Watanabe, Hiroaki Yamagishi, Ayako Fujii, Osamu Yoshida, Naohiro Yoshida
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Nitrous oxide (N2O) contributes to global warming and stratospheric ozone depletion. Although its major sources are regarded as bacterial or archaeal nitrification and denitrification in soil and water, the origins of ubiquitous marine N2O maximum at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26e16e23d89bca5d29c6303dd4ff577
http://hdl.handle.net/10659/00006654
http://hdl.handle.net/10659/00006654
Publikováno v:
Inorganic Chemistry. 54:11584-11586
We synthesized ruthenium complexes bearing a tris(pyrazol-3-ylmethyl)amine ligand LH3 and revealed that this tripodal ligand allows predictable accumulation of three proton-delivering NH groups around a coordination site. The Brønsted acidity of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f39da3a881f93dcc52f568c58bbd94
https://doi.org/10.1021/acs.inorgchem.5b02044
https://doi.org/10.1021/acs.inorgchem.5b02044