Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Hiroaki, Wakiyama"'
Autor:
Takuya Kato, Hiroshi Fukushima, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Seiichiro Takao, Peter L. Choyke, Hisataka Kobayashi
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The immune system is recognized as an important factor in regulating the development, progression, and metastasis of cancer. Myeloid-derived suppressor cells (MDSCs) are a major immune-suppressive cell type by interfering with T cell activation, prom
Externí odkaz:
https://doaj.org/article/3415fdfaa92c40b6afc4099d573dfa01
Autor:
Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hiroaki Wakiyama, Takuya Kato, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that utilizes an antibody-photoabsorber-conjugate (AbPC) combined with NIR light. The AbPC is injected and binds to the tumor whereupon NIR light irradiation causes a ph
Externí odkaz:
https://doaj.org/article/c84b464ade6a4b16a0279abd843ce507
Autor:
Qingjiang Hu, Kentaro Nonaka, Hiroaki Wakiyama, Yu Miyashita, Yoshiaki Fujimoto, Tomoko Jogo, Kentaro Hokonohara, Ryota Nakanishi, Yuichi Hisamatsu, Koji Ando, Yasue Kimura, Takaaki Masuda, Eiji Oki, Koshi Mimori, Yoshinao Oda, Masaki Mori
Publikováno v:
Cancer Medicine, Vol 10, Iss 9, Pp 3129-3138 (2021)
Abstract Background A simple measure of immune cytolytic activity (CYT) base on mRNA expression levels of two genes, GZMA and PRF1, was recently reported. Here, we aimed to evaluate the CYT score's potential as a measure of antitumor immunity and pre
Externí odkaz:
https://doaj.org/article/3098840b08a948468be8da267e6db5f6
Autor:
Adrian Rosenberg, Fuyuki Inagaki, Takuya Kato, Ryuhei Okada, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi
Publikováno v:
Cancer Medicine, Vol 9, Iss 16, Pp 5932-5939 (2020)
Abstract Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel cancer therapy that employs a combination of infrared light and tumor‐targeted monoclonal antibody‐photoabsorber conjugates to cause both direct tumor necrosis and immunogenic cel
Externí odkaz:
https://doaj.org/article/9458232a636a4ba8b0984da1c8fbd79d
Publikováno v:
EBioMedicine, Vol 70, Iss , Pp 103501- (2021)
Near-infrared photoimmunotherapy (NIR-PIT) is a newly-developed, highly-selective cancer treatment, which utilizes a monoclonal antibody conjugated to a photoabsorbing dye, IRDye700DX (IR700). The antibody conjugate is injected into the patient and a
Externí odkaz:
https://doaj.org/article/40420269d68f4cc7a0f31f2c1cdd7f2f
Autor:
Fuyuki F. Inagaki, Takuya Kato, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2037 (2022)
Disialoganglioside (GD2) is a subtype of glycolipids that is highly expressed in tumors of neuroectodermal origins, such as neuroblastoma and osteosarcoma. Its limited expression in normal tissues makes GD2 a potential target for precision therapy. S
Externí odkaz:
https://doaj.org/article/db12965043f24da89b7813c9ba078ca5
Autor:
Ryuhei Okada, Aki Furusawa, Daniel W. Vermeer, Fuyuki Inagaki, Hiroaki Wakiyama, Takuya Kato, Tadanobu Nagaya, Peter L. Choyke, William C. Spanos, Clint T. Allen, Hisataka Kobayashi
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103345- (2021)
Background: near-infrared photoimmunotherapy (NIR-PIT) is a cancer treatment that uses antibody-photoabsorber (IRDye700DX, IR700) conjugates (APCs) which bind to target cells and are photoactivated by NIR light inducing rapid necrotic cell death. NIR
Externí odkaz:
https://doaj.org/article/5759f07f0e9d4c66ad7deed5fb53a420
Autor:
Hideyuki Furumoto, Takuya Kato, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 846 (2022)
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed and promising therapy that specifically destroys target cells by irradiating antibody-photo-absorber conjugates (APCs) with NIR light. APCs bind to target molecules on the cell surface,
Externí odkaz:
https://doaj.org/article/872dbe9b01e942fbbc98c43dff386f4a
Autor:
Adrian Rosenberg, Daiki Fujimura MD, Ryuhei Okada MD, PhD, Aki Furusawa PhD, Fuyuki Inagaki MD, PhD, Hiroaki Wakiyama MD, PhD, Takuya Kato MD, PhD, Peter L. Choyke MD, Hisataka Kobayashi MD, PhD
Publikováno v:
Molecular Imaging, Vol 19 (2020)
Background: Near-infrared photoimmunotherapy (NIR-PIT) is a cancer therapy that causes an increase in tumor perfusion, a phenomenon termed the super-enhanced permeability and retention effect. Currently, in vivo treatment efficacy of NIR-PIT is obser
Externí odkaz:
https://doaj.org/article/940fa7e2050d4118b9a413114e40e0bd
Autor:
Osamu Hisano, Takeshi Nonoshita, Hidenari Hirata, Tomonari Sasaki, Hideyuki Watanabe, Hiroaki Wakiyama, Minoru Ono, Saiji Ohga, Hiroshi Honda
Publikováno v:
Radiation Oncology, Vol 13, Iss 1, Pp 1-7 (2018)
Abstract Background Endoscopic submucosal dissection (ESD) can be used as a less invasive treatment option for superficial esophageal cancer involving the muscularis mucosae (T1a-MM) or upper third of the submucosa (T1b-SM1). Additional treatment aft
Externí odkaz:
https://doaj.org/article/eeaa5ac179424605bff0814e15e38b97