Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Hiroaki, Wake"'
Autor:
Ryotaro Oishi, Ikuko Takeda, Yukihito Ode, Yuya Okada, Daisuke Kato, Hiroaki Nakashima, Shiro Imagama, Hiroaki Wake
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Spinal cord injury (SCI) is damage or trauma to the spinal cord, which often results in loss of function, sensation, or mobility below the injury site. Transcranial direct current stimulation (tDCS) is a non-invasive and affordable brain sti
Externí odkaz:
https://doaj.org/article/4d37e6be5b184806ba4b0275b552eee3
Autor:
Shingo Miyata, Hiroaki Wake
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/ccf2599a6db44c9ba04befbdfce4a4da
Autor:
Dennis Lawrence Cheung, Takuya Toda, Madoka Narushima, Kei Eto, Chitoshi Takayama, Tatsuko Ooba, Hiroaki Wake, Andrew John Moorhouse, Junichi Nabekura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl−] and depolarized GABAergic signaling. This phenotype mirrors immature neurons wherein GABA-evoked depolarizations facilit
Externí odkaz:
https://doaj.org/article/a84d0a83f5ea4143ab39f19a7adf745c
Autor:
Norihiro Imai, Yuki Ohsaki, Jinglei Cheng, Jingjing Zhang, Fumitaka Mizuno, Taku Tanaka, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami, Hiroaki Wake, Hiroki Kawashima
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Lipid droplets (LDs) have been observed in the nuclei of hepatocytes; however, their significance in liver disease remains unresolved. Our purpose was to explore the pathophysiological features of intranuclear LDs in liver diseases. We inclu
Externí odkaz:
https://doaj.org/article/cbcdd40a7e6244acaa3c352ebdd6a8e6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Oligodendrocytes (OCs) form myelin around axons, which is dependent on neuronal activity. This activity-dependent myelination plays a crucial role in training and learning. Previous studies have suggested that neuronal activity regulates proliferatio
Externí odkaz:
https://doaj.org/article/e6727e54c54648ffb69598053ad47075
Autor:
Ikuko Takeda, Kohei Yoshihara, Dennis L. Cheung, Tomoko Kobayashi, Masakazu Agetsuma, Makoto Tsuda, Kei Eto, Schuichi Koizumi, Hiroaki Wake, Andrew J. Moorhouse, Junichi Nabekura
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Astrocytes may contribute to synaptic remodelling in the cortex in chronic pain states. Here the authors describe modulation of astrocyte activity to drive circuit reorganization in somatosensory cortex in mice, along with peripheral nerve block, whi
Externí odkaz:
https://doaj.org/article/f9e5b2155e06424d8556f494c3f4191f
Autor:
Anri Hirai, Shouta Sugio, Collins Nimako, Shouta M. M. Nakayama, Keisuke Kato, Keisuke Takahashi, Koji Arizono, Tetsushi Hirano, Nobuhiko Hoshi, Kazutoshi Fujioka, Kumiko Taira, Mayumi Ishizuka, Hiroaki Wake, Yoshinori Ikenaka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their ass
Externí odkaz:
https://doaj.org/article/043eedf362e04a0e9e9345834d4e69da
Autor:
Yuki Hattori, Daisuke Kato, Futoshi Murayama, Sota Koike, Hisa Asai, Ayato Yamasaki, Yu Naito, Ayano Kawaguchi, Hiroyuki Konishi, Marco Prinz, Takahiro Masuda, Hiroaki Wake, Takaki Miyata
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112092- (2023)
Summary: The relationships between tissue-resident microglia and early macrophages, especially their lineage segregation outside the yolk sac, have been recently explored, providing a model in which a conversion from macrophages seeds microglia durin
Externí odkaz:
https://doaj.org/article/148cd26b7af944d7bd1d14fdcd7d9a0c
Autor:
Kana Ozaki, Daisuke Kato, Ako Ikegami, Akari Hashimoto, Shouta Sugio, Zhongtian Guo, Midori Shibushita, Tsuyako Tatematsu, Koichiro Haruwaka, Andrew J. Moorhouse, Hideto Yamada, Hiroaki Wake
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA)
Externí odkaz:
https://doaj.org/article/979f3c83c7a34bd2aeab127d90ed220a