Zobrazeno 1 - 10
of 462
pro vyhledávání: '"Hiroaki, Suga"'
Autor:
M. Teresa Bertran, Robert Walmsley, Thomas Cummings, Iker Valle Aramburu, Donald J. Benton, Rocio Mora Molina, Jayalini Assalaarachchi, Maria Chasampalioti, Tessa Swanton, Dhira Joshi, Stefania Federico, Hanneke Okkenhaug, Lu Yu, David Oxley, Simon Walker, Venizelos Papayannopoulos, Hiroaki Suga, Maria A. Christophorou, Louise J. Walport
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Peptidylarginine deiminase IV (PADI4, PAD4) deregulation promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. PADI4 additionally mediates immune responses and cellular reprogramming, although the
Externí odkaz:
https://doaj.org/article/f39911ea87f547c599b7661118b8999a
Autor:
Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110426- (2024)
Summary: The regenerative functions associated with cytokines and growth factors have immense therapeutic potential; however, their poor pharmacokinetics, resulting from structural features, hinder their effectiveness. In this study, we aimed to enha
Externí odkaz:
https://doaj.org/article/0d8d58bd76f444259d5c7598ca8e3f20
Autor:
Betsegaw Lemma, Di Zhang, Ganga B. Vamisetti, Bryan G. Wentz, Hiroaki Suga, Ashraf Brik, Jacek Lubkowski, David Fushman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Post-translational modification of proteins with polyubiquitin chains is a critical cellular signaling mechanism in eukaryotes with implications in various cellular states and processes. Unregulated ubiquitin-mediated protein degradation can
Externí odkaz:
https://doaj.org/article/9058e9e4ef084ba383c97031acda0042
Publikováno v:
ACS Central Science, Vol 9, Iss 11, Pp 2150-2160 (2023)
Externí odkaz:
https://doaj.org/article/58e522cc16f844b5b8811192f9978df9
Publikováno v:
ACS Bio & Med Chem Au, Vol 3, Iss 5, Pp 429-437 (2023)
Externí odkaz:
https://doaj.org/article/2e5325a096c84a189ae725309c7bfaad
Autor:
Ganga B. Vamisetti, Abhishek Saha, Yichao J. Huang, Rajeshwer Vanjari, Guy Mann, Julia Gutbrod, Nabieh Ayoub, Hiroaki Suga, Ashraf Brik
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Finding a selective modulator of Lys63-linked ubiquitin chains has proven very challenging. Here, the authors develop potent macrocyclic peptide binders of Lys63-linked di-ubiquitin chains that interrupt DNA damage repair and lead to apoptotic cell d
Externí odkaz:
https://doaj.org/article/58bf01b34e824cffb9c42931201d476a
Autor:
Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Thi Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here, the authors report bi-functional, wide tropic macrocycles that bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion and show efficacy in preventing severe pneumonia at later stage
Externí odkaz:
https://doaj.org/article/c9870560bd824a40938a1a8131ac4429
Autor:
Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga, Junichi Takagi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain b
Externí odkaz:
https://doaj.org/article/b6402a431ea3401381e2112d57500bf8
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Azoles are five-membered heterocycles found in peptidic natural products and synthetic peptiodomimetics. Here the authors demonstrate a posttranslational chemical modification method for in vitro ribosomal synthesis of peptides with exotic azole grou
Externí odkaz:
https://doaj.org/article/6bddf073720e4273a7a78d0eb520df7e
Autor:
Ziyang Zhang, Rong Gao, Qi Hu, Hayden Peacock, D. Matthew Peacock, Shizhong Dai, Kevan M. Shokat, Hiroaki Suga
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1753-1761 (2020)
Externí odkaz:
https://doaj.org/article/5b135c4d313345b2b45134bdfd6e226c