Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hiroaki, Nejishima"'
Publikováno v:
Journal of Toxicologic Pathology
Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754463d5f806496e1499d813876f0c57
http://europepmc.org/articles/PMC8100254
http://europepmc.org/articles/PMC8100254
Autor:
Kunitoshi Imai, Haruko Ogawa, Tohru Kihara, Kanata Ibi, Hiroaki Nejishima, Yutaka Yonezawa, Yohei Takeda, Masanori Senshu
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1120-1127
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Hydroxytyrosol (HT) is a simple phenol compound present in olive oil. In a previous in vitro study, we showed that HT downregulated lipopolysaccharide-mediated expression of inducible nitric oxide synthase, cyclooxygenase-2 (COX-
Hydroxytyrosol (HT) is a simple phenol compound present in olive oil. In a previous in vitro study, we showed that HT downregulated lipopolysaccharide-mediated expression of inducible nitric oxide synthase, cyclooxygenase-2 (COX-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea895a268964810a942303d9cd8f0e38
https://doi.org/10.1248/bpb.b18-00979
https://doi.org/10.1248/bpb.b18-00979
Autor:
Taishi, Miyashita, Masanori, Senshu, Kanata, Ibi, Hiroyuki, Yamanaka, Hiroaki, Nejishima, Tatsuki, Fukami, Miki, Nakajima
Publikováno v:
Toxicology. 465:153064
Drug-induced lens opacity has the potential to cause blindness and is of concern in drug development. Inhibition of cholesterol biosynthesis is one of the causes of lens opacity. Lens opacity is only observed after chronic administration in in vivo n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f8c451988d42314d739e82b6b044e2
https://doi.org/10.1016/j.tox.2021.153064
https://doi.org/10.1016/j.tox.2021.153064
Autor:
Taishi Miyashita, Yutaka Yonezawa, Haruko Ogawa, Yohei Takeda, Kunitoshi Imai, Hiroaki Nejishima
Publikováno v:
The Journal of Veterinary Medical Science
The control of inflammation, which arises from complex biological responses to harmful stimuli, is an important determinant of both clinical outcomes and patient comfort. However, the side effects of many current therapies such as non-steroidal anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8fbd5f3bee3b3bd72f8642b58a27ff
https://pubmed.ncbi.nlm.nih.gov/30298817
https://pubmed.ncbi.nlm.nih.gov/30298817
Autor:
Taishi Miyashita, Hiroaki Nejishima, Kazuto Hashimoto, Haruko Ogawa, Yutaka Yonezawa, Akira Kataoka, Tomoka Ohsumi
Publikováno v:
The Journal of Toxicological Sciences. 40:667-683
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Guinea pigs are the most frequently used animals in phototoxicity studies. However, general toxicity studies most often use Sprague-Dawley (SD) rats. To reduce the number of animals needed for drug development, we examined whethe
Guinea pigs are the most frequently used animals in phototoxicity studies. However, general toxicity studies most often use Sprague-Dawley (SD) rats. To reduce the number of animals needed for drug development, we examined whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f4cdb657f042631f8fa60675cb648d
https://doi.org/10.2131/jts.40.667
https://doi.org/10.2131/jts.40.667
Autor:
Hiroaki Nejishima, Yutaka Yonezawa, Kazuto Hashimoto, Hiroko Ashizawa, Taishi Miyashita, Haruko Ogawa
Publikováno v:
The Journal of toxicological sciences. 42(2)
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Previously, we showed that phototoxicity assessments in Sprague-Dawley (SD) rats can detect phototoxic potential to the same degree as those in guinea pigs. In this study, we examined whether phototoxicity assessments can be inco
Previously, we showed that phototoxicity assessments in Sprague-Dawley (SD) rats can detect phototoxic potential to the same degree as those in guinea pigs. In this study, we examined whether phototoxicity assessments can be inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3841df5c1872814614fc9166ed39754
https://pubmed.ncbi.nlm.nih.gov/28321041
https://pubmed.ncbi.nlm.nih.gov/28321041
Autor:
Radhakrishnan Pillai, Marian Glynn, William J. Jo, Kenji Minowa, Hisakazu Sanada, Linda Mutter, Barry Calvarese, Hiroaki Nejishima, Hisato Senda
Publikováno v:
Regulatory Toxicology and Pharmacology. 70:242-253
Efinaconazole is a triazole developed as a 10% solution for topical treatment of onychomycosis, a common fungal nail infection. Efinaconazole solution and topical formulation vehicle administered dermally to mice (13weeks), rats (6months) and minipig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85a8c8e429786a7f031f72907f7c4b2
https://doi.org/10.1016/j.yrtph.2014.07.012
https://doi.org/10.1016/j.yrtph.2014.07.012
Autor:
Naoya Nagata, Noriko Yamamoto, Mika Suzuki, Hiroaki Nejishima, Kazuyuki Furuya, Shizuo Yamada
Publikováno v:
The Prostate. 72:1580-1587
BACKGROUND Selective androgen receptor modulators (SARMs) would provide alternative therapeutic agent for androgen-related diseases. We identified a tetrahydroquinoline (THQ) derivative, 1-(8-nitro-3a, 4, 5, 9b-tetrahydro-3H-cyclopenta[c]quinolin-4-y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79809ecb7cc8101b6c58b1ed8524b995
https://doi.org/10.1002/pros.22511
https://doi.org/10.1002/pros.22511
Autor:
Mitsuo Mimura, Noriko Yamamoto, Kazuyuki Furuya, Mika Suzuki, Shizuo Yamada, Hiroaki Nejishima
Publikováno v:
Lower urinary tract symptoms. 5(1)
Objectives: The current study was undertaken to explore novel anti-androgens. We investigated a series of tetrahydroquinoline compounds and identified 1-(8-nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)ethane-1,2-diol (S-40542). Methods: A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e51cf83a169d5d106354f853972b19b
https://pubmed.ncbi.nlm.nih.gov/26663247
https://pubmed.ncbi.nlm.nih.gov/26663247
Autor:
Motonori Miyakawa, Noriko Yamamoto, Naoya Nagata, Kazuyuki Furuya, Kiyoshi Inoguchi, Seiji Amano, Hiroaki Nejishima
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6310-6313
A rationally designed tetrahydroquinoline (1) for nonsteroidal selective androgen receptor modulators was modified for the exploration of promising compounds by Grieco three-component condensation using various dienophiles. Based on the in vitro effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca88a3a09dab4820253cda684b3ffa4f
https://doi.org/10.1016/j.bmcl.2011.08.118
https://doi.org/10.1016/j.bmcl.2011.08.118