Výsledky vyhledávání - "Hiroaki, Naraba"

A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells

Autor: Kazuhiro Tamura, Takahiko Hara, Hiroaki Naraba, Kota Nakamura, Mikihiro Yoshie, Eiichi Tachikawa, Hiroshi Kogo

Publikováno v: Prostaglandins & Other Lipid Mediators. 123:56-62

Microsomal prostaglandin E synthase-1 (mPGES-1) is primarily expressed in granulosa cells (GCs) in the preovulatory follicle. Both prostaglandin E2 (PGE2) and progesterone (P4) are implicated in various reproductive functions. Here, we demonstrate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb1cdd48706acfe09126e6f0ccc2815
https://doi.org/10.1016/j.prostaglandins.2016.05.002

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The intrinsic structure of glucose transporter isoforms Glut1 and Glut3 regulates their differential distribution to detergent-resistant membrane domains in nonpolarized mammalian cells

Autor: Tomoko Sakyo, Hirobumi Teraoka, Hiroaki Naraba, Takayuki Kitagawa

Publikováno v: FEBS Journal. 274:2843-2853

The hexose transporter family, which mediates facilitated uptake in mammalian cells, consists of more than 10 members containing 12 membrane-spanning segments with a single N-glycosylation site. We previously demonstrated that glucose transporter 1 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b796759b21adf60ba943a952c8b8648
https://doi.org/10.1111/j.1742-4658.2007.05814.x

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Polymorphisms in human pre-miRNAs

Autor: Naoharu Iwai, Hiroaki Naraba

Publikováno v: Biochemical and Biophysical Research Communications. 331:1439-1444

MicroRNAs constitute a growing class of non-coding RNAs that are thought to regulate gene expression via translational repression. MicroRNAs are initially transcribed as several hundred-nucleotide pri-miRNAs and are then processed to approximately 60

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949347a1516dadea5e646af3abc0bfe9
https://doi.org/10.1016/j.bbrc.2005.04.051

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Association Analysis Between Hypertension and CYBA, CLCNKB, and KCNMB1 Functional Polymorphisms in the Japanese Population-The Suita Study

Autor: Hiroaki Naraba, Hitonobu Tomoike, Yoshihiro Kokubo, Akira Okayama, Nozomu Inamoto, Naomi Tago, Hideyuki Yamawaki, Naoharu Iwai

Publikováno v: Circulation Journal. 69:138-142

Background Reproducibility of results is important for the validity of genetic association studies. Recently, 3 functional polymorphisms, G(-930)A in CYBA, T481S in CLCNKB, and E65K in KCNMB1, were reported to be associated with blood pressure (BP) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d63e81a9c3fad3e8b03d352458f43789
https://doi.org/10.1253/circj.69.138

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Microsomal Prostaglandin E Synthase-1 Is Overexpressed in Inflammatory Bowel Disease

Autor: Tadashi Tanabe, Hiroaki Naraba, Kenneth D. Glazier, Dragan Golijanin, Andrew J. Dannenberg, Kiron M. Das, Ellen Scherl, Robert A. Soslow, Kazuhiko Yoshimatsu, Kotha Subbaramaiah

Publikováno v: Journal of Biological Chemistry. 279:12647-12658

Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the conversion of cyclooxygenase-derived prostaglandin (PG) H(2) to PGE(2). Increased amounts of mPGES-1 were detected in inflamed intestinal mucosa from patients with inflammatory bowel disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1814c99e0327b5c5c07559ccf6710f8
https://doi.org/10.1074/jbc.m312972200

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A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population

Autor: Toshiyuki Miyata, Hiroaki Naraba, Masayoshi Yoshii, Yoichi Goto, Toshifumi Mannami, Naomi Tago, Junko Nishioka, Hiroshi Nonogi, Shunichi Miyazaki, Yuhei Kawano, Yoshikazu Miwa, Kei Kamide, Naoharu Iwai, Shin Takiuchi, Keisuke Shioji, Nozomu Inamoto, Yoshihiro Kokubo

Publikováno v: Journal of Human Genetics. 49:141-147

To investigate the effects of polymorphisms in the ATP-binding cassette transporter A1 ( ABCA1) gene on the high-density lipoprotein cholesterol (HDL-C) level and the incidence of myocardial infarction (MI), we performed association studies. Sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3f5f5298ba47359cedda27c4dd9fa3
https://doi.org/10.1007/s10038-004-0124-9

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Prostaglandin E2is an enhancer of interleukin-1β-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts

Autor: Hiroaki Naraba, Haruhito Aoki, Moroe Beppu, Shinichi Kawai, Fumiaki Kojima, Yasuharu Sasaki

Publikováno v: Arthritis & Rheumatism. 48:2819-2828

Objective Membrane-associated prostaglandin E synthase (mPGES) is a recently identified terminal enzyme of the arachidonic acid cascade, which converts PGH2 to PGE2 in rheumatoid arthritis synovial fibroblasts (RASFs). This study was undertaken to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::127d117d1ce873ae2877e676812c7984
https://doi.org/10.1002/art.11261

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Prostaglandin receptors IP and EP mediating regulation of tumor necrosis factor-alpha and interleukin-10 production

Autor: Iku Utsunomiya, Koichi Yuki, Shiho Shinomiya, Shuichi Ohuchida, Hiroaki Naraba, Sachiko Oh-ishi, Akinori Ueno, Fumitaka Ushikubi, Takayuki Maruyama, Atsushi Ichikawa, Shuh Narumiya, Yukihiko Sugimoto

Publikováno v: International Congress Series. 1233:479-484

We examined the roles of prostaglandin receptors regulating tumor necrosis factor-alpha (TNFα) and IL-10 production by zymosan-stimulated murine peritoneal macrophages. During the stimulation with zymosan for 5 h, the presence of PGE2 or carbacyclin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::378be03955b1ea34381e7a2bcefe7390
https://doi.org/10.1016/s0531-5131(02)00596-4

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Transcriptional Regulation of the Membrane-associated Prostaglandin E2 Synthase Gene

Autor: Naomi Tago, Tadashi Tanabe, Hiroaki Naraba, Chieko Yokoyama, Makoto Murakami, Mai Fueki, Sachiko Oh-ishi, Ichiro Kudo

Publikováno v: Journal of Biological Chemistry. 277:28601-28608

Membrane-associated prostaglandin (PG) E2 synthase (mPGES) is an inducible terminal enzyme in the biosynthetic pathway for prostaglandin E2, which participates in many biological processes. In this study, we investigated the molecular mechanism contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cbb3493d0221f5f6dac95573e4ebd77
https://doi.org/10.1074/jbc.m203618200

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