Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Hiroaki, Hemmi"'
Autor:
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J. Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113981- (2024)
Summary: Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopol
Externí odkaz:
https://doaj.org/article/f22ab996a6a3412b82cc9ee0414c17dd
Autor:
Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Satoru Hamada, Kazuya Hamada, Norio Kawamoto, Saori Kadowaki, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Miyuki Tsumura, Yusuke Yamashita, Shinobu Tamura, Takashi Orimo, Toshiya Ozasa, Takashi Kato, Izumi Sasaki, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Yutaka Inaba, Kayo Kunimoto, Satoshi Okada, Takeshi Taketani, Koichi Nakanishi, Shigeo Murata, Koh-ichiro Yoshiura, Tsuneyasu Kaisho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Genetic variants of proteasome subunit genes have been shown to associate with perturbed immune function. Here authors show that a heterozygous missense variant of the immunoproteasome subunit β-type 9 causes an autoinflammatory/immune deficiency sy
Externí odkaz:
https://doaj.org/article/bc153bd94dab48289d8e89f5cfa52002
Autor:
Daiki Hashimoto, Jose Gabriel R. Colet, Aki Murashima, Kota Fujimoto, Yuko Ueda, Kentaro Suzuki, Taiju Hyuga, Hiroaki Hemmi, Tsuneyasu Kaisho, Satoru Takahashi, Yousuke Takahama, Gen Yamada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The thymus facilitates mature T cell production by providing a suitable stromal microenvironment. This microenvironment is impaired by radiation and aging which lead to immune system disturbances known as thymic involution. Young adult thymu
Externí odkaz:
https://doaj.org/article/8af00c56932d4c45b9aec80fe2653355
Autor:
Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions. One DC subset, conventional type 1 DC (cDC1), can be defined by expression of CD8α/CD103 in
Externí odkaz:
https://doaj.org/article/20ea9d4a9ec94694a339a3d4eab24e4f
Autor:
Taiki Moriya, Kurumi Kitagawa, Yuuki Hayakawa, Hiroaki Hemmi, Tsuneyasu Kaisho, Satoshi Ueha, Ryoyo Ikebuchi, Ippei Yasuda, Yasutaka Nakanishi, Tetsuya Honda, Koji Matsushima, Kenji Kabashima, Mizuki Ueda, Yutaka Kusumoto, Tatyana Chtanova, Michio Tomura
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102424- (2021)
Summary: Immunogenic tumor cell death enhances anti-tumor immunity. However, the mechanisms underlying this effect are incompletely understood. We established a system to induce tumor cell death in situ and investigated its effect on dendritic cell (
Externí odkaz:
https://doaj.org/article/ebf7407913484d49baa219362ed48299
Augmentation of Stimulator of Interferon Genes–Induced Type I Interferon Production in COPA Syndrome
Autor:
Takashi Orimo, Junko Takita, Hidenori Nakamura, Masaki Yamamoto, Kyoichi Isono, Toshiaki Miyamoto, Takashi Kato, Kohei Murakami, Tsuneyasu Kaisho, Tadashi Matsubayashi, Yuri Fukuda-Ohta, Hiroaki Hemmi, Yoshiro Otsuki, Yoshitaka Honda, Saki Takayama, Kazushi Izawa, Izumi Sasaki, Takahiro Yasumi, Ryuta Nishikomori
Publikováno v:
Arthritis & Rheumatology. 73:2105-2115
OBJECTIVE Coatomer subunit alpha (COPA) syndrome, also known as autoinflammatory interstitial lung, joint, and kidney disease, is caused by heterozygous mutations in COPA. We identified a novel COPA variant in 4 patients in one family. We undertook t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa245791a6aecaefb09e199c65ded2f1
https://doi.org/10.1002/art.41790
https://doi.org/10.1002/art.41790
Autor:
Tadashi Tanioku, Masayuki Nishibata, Yasuyuki Tokinaga, Kohtaro Konno, Masahiko Watanabe, Hiroaki Hemmi, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Hidemasa Furue, Tomoyuki Kawamata
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(45)
Persistent mechanical pain hypersensitivity associated with peripheral inflammation, surgery, trauma, and nerve injury impairs patients’ quality of life and daily activity. However, the molecular mechanism and treatment are not yet fully understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a344674153383d1b1a8999bb4eb8cd3f
https://pubmed.ncbi.nlm.nih.gov/36322717
https://pubmed.ncbi.nlm.nih.gov/36322717
Autor:
Keiji Hayata, Mikihito Nakamori, Tomokazu Ohta, Yuji Kitahata, Masahiro Katsuda, Hiroki Yamaue, Hiroaki Hemmi, Izumi Sasaki, Masaki Nakamura, Atsushi Miyamoto, Kenji Matsuda, Takashi Orimo, Soichiro Okura, Toshiyasu Ojima, Yuri Fukuda-Ohta, Yuki Mizumoto, Koji Tamada, Masanaka Sugiyama, Motoki Miyazawa, Tsuneyasu Kaisho
Publikováno v:
British Journal of Cancer
BackgroundCancer peptide vaccines show only marginal effects against cancers. Immune checkpoint inhibitors (ICIs) show significant curative effects in certain types of cancers, but the response rate is still limited. In this study, we aim to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6041f0e85489e4910aba13ec55f428c1
http://europepmc.org/articles/PMC7156711
http://europepmc.org/articles/PMC7156711
Autor:
Kohei Murakami, Saki Miyatake, Jiro Miyamae, Kanna Saeki, Mizutani Shinya, Natsuki Akashi, Ikki Mitsui, Kosuke Kobayashi, Kohei Saeki, Noritaka Maeta, Teppei Kanda, Yasuhiko Okamura, Hiroaki Hemmi
Publikováno v:
Veterinary Immunology and Immunopathology. 253:110505
Cancers utilize a variety of molecules to escape host immune responses. Better understanding the immune environment surrounding cancer may facilitate application of innovative cancer immunotherapies, such as immune checkpoint inhibitors, to dogs as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d74c743b7ae665a41b750b9d22fd421
https://doi.org/10.1016/j.vetimm.2022.110505
https://doi.org/10.1016/j.vetimm.2022.110505
Autor:
Tsuneyasu Kaisho, Kohtarou Konno, Tomoyuki Kawamata, Yuri Ohta, Yasuyuki Tokinaga, Masahiko Watanabe, Tadashi Tanioku, Masayoshi Nishibata, Hiroaki Hemmi
Persistent mechanical hyperalgesia, associated with peripheral inflammation and tissue injury, impairs patient’s quality of life and daily activity. However, its molecular mechanism and treatment are yet to be deciphered. Herein, we report that Tme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dce61c71c03dff80885761c05fe60c
https://doi.org/10.21203/rs.3.rs-829215/v1
https://doi.org/10.21203/rs.3.rs-829215/v1
