Výsledky vyhledávání - "Hiro Wakasugi"

Interleukin (IL)-4 promotes T helper type 2-biased natural killer T (NKT) cell expansion, which is regulated by NKT cell-derived interferon-γ and IL-4

Autor: Mitsuzi Yoshida, Gary Quinn, Yoichi Takaue, Akira Iizuka, Masanobu Kitagawa, Yoshinori Ikarashi, Kazuyoshi Takeda, Yuji Heike, Hiro Wakasugi

Publikováno v: Immunology. 123:100-107

CD1d-restricted natural killer T (NKT) cells can rapidly produce T helper type 1 (Th1) and Th2 cytokines and also play regulatory or pathological roles in immune responses. NKT cells are able to expand when cultured with alpha-galactosylceramide (alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c7a2ab6be0843ae0d987398bffd78
https://doi.org/10.1111/j.1365-2567.2007.02732.x

Zobrazit plný text záznamu

Modulation of acute graft-versus-host disease and chimerism after adoptive transfer of in vitro-expanded invariant Vα14 natural killer T cells

Autor: Yuji Heike, Yoshinori Ikarashi, Masahiro Asaka, Mitsuzi Yoshida, Akira Iizuka, Chihiro Kawakami, Gary Quinn, Yoichi Takaue, Hiro Wakasugi, Masaki Kuwatani

Publikováno v: Immunology Letters. 106:82-90

Mouse natural killer T cells with an invariant Valpha14-Jalpha18 TCR rearrangement (Valpha14i NKT cells) are able to regulate immune responses through rapid and large amounts of Th1 and Th2 cytokine production. It has been reported that in vivo admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac4b88be5b252340fe980f14027d86a
https://doi.org/10.1016/j.imlet.2006.05.001

Zobrazit plný text záznamu

The dialogue between natural killer cells and dendritic cells

Autor: Cédric Ménard, Laurence Zitvogel, Julien Taieb, Christophe Borg, Magali Terme, Koji Maruyama, Hiro Wakasugi

Publikováno v: International Congress Series. 1285:169-176

Natural killer (NK) cells play an important role in the early innate response against cancer and infections whereas dendritic cells (DC) are critical in the initiation of adaptive immune responses through their unique antigen presentation capacities.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2961187b067d3c36e64910e3e70d2ea7
https://doi.org/10.1016/j.ics.2005.07.081

Zobrazit plný text záznamu

An Irradiation-Free Nonmyeloablative Bone Marrow Transplantation Model: Importance of the Balance between Donor T-cell Number and the Intensity of Conditioning

Autor: Masahiro Asaka, Hiro Wakasugi, Masaki Kuwatani, Shin Mineishi, Yoshinori Ikarashi

Publikováno v: Transplantation. 80:1145-1152

Background. Animal allogeneic bone marrow transplantation (BMT) models with nonmyeloablative conditioning regimens have so far required irradiation or antibodies in addition to immunosuppressive drugs for engraftment. Moreover, although it is known t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cabd0cfeb6d9a4fc2dd392d80a4b7a
https://doi.org/10.1097/01.tp.0000183289.79693.3d

Zobrazit plný text záznamu

Phenotypical and functional alterations during the expansion phase of invariant Valpha14 natural killer T (Valpha14i NKT) cells in mice primed with alpha-galactosylceramide

Autor: Mitsuzi Yoshida, Mitchell Kronenberg, Yumie Koshidaka, Hiro Wakasugi, Yoichi Takaue, Yuji Heike, Yoshinori Ikarashi, Akira Iizuka

Publikováno v: Immunology. 116:30-37

Invariant Valpha14 natural killer T (Valpha14i NKT) cells are a unique immunoregulatory T-cell population that is restricted by CD1d. The glycolipid alpha-galactosylceramide (alpha-GalCer) is presented by CD1d and causes robust Valpha14i NKT-cell act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7562c16d6dd83ec48b55f91905880b73
https://doi.org/10.1111/j.1365-2567.2005.02193.x

Zobrazit plný text záznamu

Expansion of α-Galactosylceramide-Stimulated Vα24+ NKT Cells Cultured in the Absence of Animal Materials

Autor: Ryuji Tanosaki, Hiroyuki Kawai, Mitsuji Yoshida, Yukie Harada, Shin Ichiro Mori, Shigeru Saito, Akihiro Shimosaka, Masahiro Kami, Tadao Kakizoe, Yoichi Takaue, Hiro Wakasugi, Masao Takei, Yuji Heike, Osamu Imataki, Akira Iizuka, Yoshinori Ikarashi

Publikováno v: Journal of Immunotherapy. 28:314-321

Valpha24+ NKT is an innate lymphocyte with potential antitumor activity. Clinical applications of Valpha24+ natural killer (NK) T cells, which are innate lymphocytes with potential antitumor activity, require their in vitro expansion. To avoid the po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73841eea8f31f89cb1c205c94f4a355
https://doi.org/10.1097/01.cji.0000163593.66910.ad

Zobrazit plný text záznamu

Accelerated chemically induced tumor development mediated by CD4 + CD25 + regulatory T cells in wild-type hosts

Autor: Isao Tawara, Lloyd J. Old, Kanako Saito, Yoshinori Ikarashi, Linan Wang, Takuma Kato, Toshinori Nakayama, Hiroyoshi Nishikawa, Tetsushi Takemitsu, Hiroshi Shiku, Masaru Taniguchi, Hiro Wakasugi, Kagemasa Kuribayashi

Publikováno v: Proceedings of the National Academy of Sciences. 102:9253-9257

We examined the role of CD4 + CD25 + regulatory T cells in the development of 3-methylcholanthrene (MCA)-induced tumors. Immunization of wild-type BALB/c mice with a series of SEREX (serological identification of antigens by recombinant expression cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b787813a67364802e5985f24253e6b4
https://doi.org/10.1073/pnas.0503852102

Zobrazit plný text záznamu

NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs

Autor: Anne Caignard, Sabine Charrier, Anne Galy, Alessandra Cambi, Diego Laderach, Bernhard Ryffel, Kouji Maruyama, William Vainchenker, Laurence Zitvogel, Christophe Borg, Hiro Wakasugi, Abdelali Jalil, Carl G. Figdor

Publikováno v: Blood, 104, 10, pp. 3267-75
Blood, 104, 3267-75

Mature dendritic cells (mDCs) can trigger the effector functions of natural killer (NK) cells. Knock-out, small-interfering RNA or neutralizing antibodies targeting interleukin 12 (IL-12) subunits revealed a critical role for IL-12 in NK cell interfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a74cdafc5b0f1c6f69bb5b624d2795
https://doi.org/10.1182/blood-2004-01-0380

Zobrazit plný text záznamu

Immune reconstitution following reduced-intensity transplantation with cladribine, busulfan, and antithymocyte globulin: serial comparison with conventional myeloablative transplantation

Autor: Yoshinobu Kanda, Yuji Heike, T Saito, Shin Mineishi, Hiro Wakasugi, M. Kami, Yoichi Takaue, Ryuji Tanosaki, Kensei Tobinai, K Nakai, F. Arima, Sung-Won Kim

Publikováno v: Bone Marrow Transplantation. 32:601-608

The primary object of the conditioning regimen for allogeneic reduced-intensity stem cell transplantation (RIST) is immunosuppression to achieve stable engraftment of donor cells, rather than bone marrow ablation. Therefore, immune reconstitution aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8685e1e56c5ca9e820aa0a290dca3258
https://doi.org/10.1038/sj.bmt.1704205

Zobrazit plný text záznamu

Impact of graft-versus-host disease in reduced-intensity stem cell transplantation (RIST) for patients with haematological malignancies

Autor: Ryuji Tanosaki, Yoshinobu Kanda, Masahiro Kami, Yoichi Takaue, Takeshi Saito, Atsushi Makimoto, Kensei Tobinai, Shin Mineishi, K Nakai, Hiro Wakasugi

Publikováno v: British Journal of Haematology. 121:296-303

To clarify the impact of graft-versus-host disease (GVHD) on the outcome of reduced-intensity stem cell transplantation (RIST), 40 patients who received RIST were compared with those who received conventional stem cell transplantation (CST). RIST reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d2527d285b7a77b8492dc3f318d73f1
https://doi.org/10.1046/j.1365-2141.2003.04281.x

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání