Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hiran Maye Thyagarajan"'
Publikováno v:
The Journal of Immunology. 206:21.07-21.07
Experimental autoimmune encephalomyelitis (EAE) is a well-described mouse model for multiple sclerosis (MS), a demyelinating autoimmune disorder of the central nervous system (CNS). While the role of CD4 T cells is well established, other immune cell
Publikováno v:
The Journal of Immunology. 200:165.19-165.19
Following positive selection, thymocytes migrate into the medulla where they encounter diverse tissue-restricted antigens (TRAs) that induce central tolerance. Both medullary thymic epithelial cells (mTECs) and dendritic cells (DCs) present TRAs to i
Publikováno v:
The Journal of Immunology. 198:60.10-60.10
Maturing thymocytes enter the thymic medulla, where they encounter numerous self-antigens presented by antigen presenting cells (APC). Those thymocytes that are strongly self-reactive undergo either negative selection or diversion into the regulatory
Publikováno v:
The Journal of Immunology. 196:204.25-204.25
Generation of functional and self-tolerant T cells in the thymus is crucial to preventing autoimmune diseases. Medullary thymic epithelial cells (mTECs) and dendritic cells (DCs) present diverse auto-antigens to developing thymocytes; strong TCR reac
Publikováno v:
The FASEB Journal. 26