Výsledky vyhledávání - "Hiral J. Patel"

Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1

Autor: Hiral J. Patel, Vladimir S. Talanov, Paul S. Plascjak, Carolyn K. Goldman, Kayhan Garmestani, Meili Zhang, Martin W. Brechbiel, John E. Janik, Thomas A. Waldmann, Zhengsheng Yao, Zhuo Zhang

Publikováno v: Proceedings of the National Academy of Sciences. 104:8444-8448

CD30 is a member of the TNF receptor superfamily. Overexpression of CD30 on some neoplasms versus limited expression on normal tissues makes this receptor a promising target for antibody-based therapy. Radioimmunotherapy of cancer with radiolabeled a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89426d89bd93f844be81098ebebff56b
https://doi.org/10.1073/pnas.0702496104

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The IL-15/IL-15Rα on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells

Autor: Thomas A. Waldmann, Yutaka Tagaya, Hiral J. Patel, Noriko Sato

Publikováno v: Proceedings of the National Academy of Sciences. 104:588-593

We previously described unique features of the IL-15 receptor (IL-15R)α. IL-15Rα by itself forms stable complexes with IL-15 on cell surfaces and presents IL-15 in trans to neighboring natural killer/T cells. Moreover, the membrane IL-15/IL-15Rα c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf2adc6f51964508969df4f617d4250
https://doi.org/10.1073/pnas.0610115104

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IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease

Autor: Brian S. Kim, Hiral J. Patel, Thomas A. Waldmann, Toshiaki Ohteki, Kazuto Ishida, Fumi Miyagawa, Yutaka Tagaya, Stephen I. Katz

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 181(2)

To elucidate the mechanisms controlling peripheral tolerance, we established two transgenic (Tg) mouse strains expressing different levels of membrane-bound OVA (mOVA) as a skin-associated self-Ag. When we transferred autoreactive TCR-Tg CD8 T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f0c54755269aab5d0ed3b7a89a335d
https://pubmed.ncbi.nlm.nih.gov/18606663

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Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action

Autor: Thomas A. Waldmann, Jiirgen R. Müller, Hiral J. Patel, Sigrid Dubois, Meili Zhang

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 180(4)

In the induction of an immune response, IL-15Rα on APCs transpresents IL-15 to NK and CD8+/CD44high T cells that express the IL-2/15Rβ and γc subunits only. In this study, we show data mimicking this transpresentation by using IL-15 preassociated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad8773f721b4c2b41f84ca7087471f4
https://pubmed.ncbi.nlm.nih.gov/18250415

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Transformation of breast cells by truncated neurokinin-1 receptor is secondary to activation by preprotachykinin-A peptides

Autor: Hiral J. Patel, Prem S. Patel, Pranela Rameshwar, Shakti Ramkissoon

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 102(48)

Breast cancer remains the cancer with the highest mortality among women in the United States. Peptides derived from the oncogenic Tac1 gene (full transcript: βPPT-A) stimulate the proliferation of breast cancer cells (BCCs) via seven-transmembrane G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca1737d9f7b1e02f511cdf2c4d8dead
https://pubmed.ncbi.nlm.nih.gov/16291810

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