Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hiraku, Takada"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Regulatory arrest peptides interact with specific residues on bacterial ribosomes and arrest their own translation. Here, we analyse over 30,000 bacterial genome sequences to identify additional Sec/YidC-related arrest peptides, followed by
Externí odkaz:
https://doaj.org/article/8325ba1e4e4d4765bbb7a5e7b7c41704
Autor:
Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Susanne Huch, Marje Kasari, Hiraku Takada, Lilit Nersisyan, Arnfinn Sundsfjord, Kristin Hegstad, Gemma C. Atkinson, Vicent Pelechano, Daniel N. Wilson, Vasili Hauryliuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
PoxtA confers resistance to ribosome-targeting oxazolidinone (linezolid) and chloramphenicol antibiotics. Here, Crowe-McAuliffe et al. provide structural insights into how binding of PoxtA to the ribosome indirectly promotes drug dissociation.
Externí odkaz:
https://doaj.org/article/05dd3c38dd694b5fb2e00d979a07f8f8
Autor:
Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Marje Kasari, Merianne Mohamad, Christine Polte, Hiraku Takada, Karolis Vaitkevicius, Jörgen Johansson, Zoya Ignatova, Gemma C. Atkinson, Alex J. O’Neill, Vasili Hauryliuk, Daniel N. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation an
Externí odkaz:
https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33
Autor:
Nozomu Obana, Hiraku Takada, Caillan Crowe-McAuliffe, Mizuki Iwamoto, Artyom A Egorov, Kelvin J Y Wu, Shinobu Chiba, Victoriia Murina, Helge Paternoga, Ben I C Tresco, Nobuhiko Nomura, Andrew G Myers, Gemma C Atkinson, Daniel N Wilson, Vasili Hauryliuk
Publikováno v:
Nucleic Acids Research. 51:4536-4554
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The diversity of chromosomally-encoded ARE-ABCFs is far from being fully exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d26f7fbc7cdcb357bec011d2f729f9
https://doi.org/10.1093/nar/gkad193
https://doi.org/10.1093/nar/gkad193
Autor:
Hiraku Takada, Mohammad Roghanian, Victoriia Murina, Ievgen Dzhygyr, Rikinori Murayama, Genki Akanuma, Gemma C. Atkinson, Abel Garcia-Pino, Vasili Hauryliuk
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be
Externí odkaz:
https://doaj.org/article/cfe3282d2ac845f788cfcf5c61081e5c
Autor:
Tetiana Brodiazhenko, Marcus J. O. Johansson, Hiraku Takada, Tracy Nissan, Vasili Hauryliuk, Victoriia Murina
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Cell-free translation systems based on cellular lysates optimized for in vitro protein synthesis have multiple applications both in basic and applied science, ranging from studies of translational regulation to cell-free production of proteins and ri
Externí odkaz:
https://doaj.org/article/16a117efad724403afafbba57939a002
Ribosome is a translational apparatus that comprises about 80 ribosomal proteins and four rRNAs. Recent studies reported that ribosome ubiquitination is crucial for translational regulation and ribosome-associated quality control (RQC). However, litt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4019d0eb20ef72ab5d3adedf8e11c3
https://doi.org/10.1101/2023.02.12.528238
https://doi.org/10.1101/2023.02.12.528238
Autor:
Andres Ainelo, Julien Caballero-Montes, Ondřej Bulvas, Karin Ernits, Kyo Coppieters ‘t Wallant, Hiraku Takada, Sophie Z. Craig, Gabriel Mazzucchelli, Safia Zedek, Iva Pichová, Gemma C. Atkinson, Ariel Talavera, Chloe Martens, Vasili Hauryliuk, Abel Garcia-Pino
Publikováno v:
Science Advances. 9
Rel stringent factors are bifunctional ribosome-associated enzymes that catalyze both synthesis and hydrolysis of the alarmones (p)ppGpp. Besides the allosteric control by starved ribosomes and (p)ppGpp, Rel is regulated by various protein factors de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9c9e1f1c16953b033af7526ae16ee0
https://doi.org/10.1126/sciadv.ade4077
https://doi.org/10.1126/sciadv.ade4077
Autor:
Nozomu Obana, Hiraku Takada, Caillan Crowe-McAuliffe, Mizuki Iwamoto, Artyom A. Egorov, Kelvin J.Y. Wu, Victoriia Murina, Helge Paternoga, Ben I.C. Tresco, Nobuhiko Nomura, Andrew G. Myers, Gemma C. Atkinson, Daniel N. Wilson, Vasili Hauryliuk
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The diversity of chromosomally-encoded ARE-ABCFs is far from being fully exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cc36fda8320347a4d762cc19615334
https://doi.org/10.1101/2022.12.05.519065
https://doi.org/10.1101/2022.12.05.519065
Autor:
Hiraku Takada, Duy Dinh Do Pham, Abel Garcia-Pino, Magdalena Petrová, Hedvig Tamman, Dominik Rejman, Radek Pohl, Hanna Ainelo, Julien Caballero-Montes, Viktor Mojr, Steffi Jimmy, Vasili Hauryliuk, Katleen Van Nerom, Mohammad Roghanian
Publikováno v:
A C S Chemical Biology
While alarmone nucleotides guanosine-3′,5′-bisdiphosphate (ppGpp) and guanosine-5′-triphosphate-3′-diphosphate (pppGpp) are archetypical bacterial second messengers, their adenosine analogues ppApp (adenosine-3′,5′-bisdiphosphate) and ppp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d0b5e32d8c65a347400f85a2022ce0
https://doi.org/10.1021/acschembio.1c00398
https://doi.org/10.1021/acschembio.1c00398